Extensions of Multiple-Group Item Response Theory Alignment: Application to Psychiatric Phenotypes in an International Genomics Consortium

GRP Investigators, WGSPD Consortium, Mansolf, M., Vreeker, A., Reise, S. P., Freimer, N. B., Glahn, D. C., Gur, R. E., Moore, T. M., Pato, C. N., Pato, M. T., Palotie, A., Holm, M., Suvisaari, J., Partonen, T., Kieseppa, T., Paunio, T., Boks, M., Kahn, R., Ophoff, R. A., Bearden, C. E., Loohuis, L. O., Teshiba, T. & DeGeorge, D., 5-Feb-2020, In : Educational and Psychological Measurement. 40 p., 0013164419897307.

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  • Extensions of Multiple-Group Item Response Theory Alignment_ Application to Psychiatric Phenotypes in an International Genomics Consortium

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  • GRP Investigators
  • WGSPD Consortium
  • Maxwell Mansolf
  • Annabel Vreeker
  • Steven P. Reise
  • Nelson B. Freimer
  • David C. Glahn
  • Raquel E. Gur
  • Tyler M. Moore
  • Carlos N. Pato
  • Michele T. Pato
  • Aarno Palotie
  • Minna Holm
  • Jaana Suvisaari
  • Timo Partonen
  • Tuula Kieseppa
  • Tiina Paunio
  • Marco Boks
  • Rene Kahn
  • Roel A. Ophoff
  • Carrie E. Bearden
  • Loes Olde Loohuis
  • Terri Teshiba
  • Daniella DeGeorge

Large-scale studies spanning diverse project sites, populations, languages, and measurements are increasingly important to relate psychological to biological variables. National and international consortia already are collecting and executing mega-analyses on aggregated data from individuals, with different measures on each person. In this research, we show that Asparouhov and Muthen's alignment method can be adapted to align data from disparate item sets and response formats. We argue that with these adaptations, the alignment method is well suited for combining data across multiple sites even when they use different measurement instruments. The approach is illustrated using data from the Whole Genome Sequencing in Psychiatric Disorders consortium and a real-data-based simulation is used to verify accurate parameter recovery. Factor alignment appears to increase precision of measurement and validity of scores with respect to external criteria. The resulting parameter estimates may further inform development of more effective and efficient methods to assess the same constructs in prospectively designed studies.

Original languageEnglish
Article number0013164419897307
Number of pages40
JournalEducational and Psychological Measurement
Publication statusPublished - 5-Feb-2020


  • test equating, differential item functioning, mega-analysis, harmonization, data integration, INTEGRATIVE DATA-ANALYSIS, VALIDATION, IMPUTATION, INTERVIEW, INFERENCE, VARIABLES, SYMPTOMS, SAMPLES, SCALES

ID: 118691324