Publication

Expression of multidrug resistance proteins, P-gp, MRP1 and LRP, in soft tissue sarcomas analysed according to their histological type and grade

Komdeur, R., Plaat, B. E. C., van der Graaf, W. T. A., Hoekstra, H. J., Hollema, H., van den Berg, E., Zwart, N., Scheper, R. J. & Molenaar, W. M., May-2003, In : European Journal of Cancer. 39, 7, p. 909-916 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

The biological behaviour of different histological types and grades of soft tissue sarcomas (STS) varies. This might result in a differing sensitivity to cytotoxic drugs. Cross-resistance to functionally and structurally distinct natural-product drugs, known as multidrug resistance (MDR), is associated with the overexpression of P-glycoprotein (P-gp), multidrug resistance-associated protein I (MRP1) and lung resistance-related protein (LRP). The purpose of this study was to evaluate the expression of P-gp, MRP1 and LRP in STS according to their histological type and grade. In 141 chemotherapy-naive STS patients, the expression of the three MDR proteins was detected by immunohistochemistry. Nine histological types were documented. These were 19% grade 1, 34% grade 2 and 47% grade 3 tumours. Expression of P-gp and LRP was observed more frequently than the expression of MRP1 (P

Original languageEnglish
Pages (from-to)909-916
Number of pages8
JournalEuropean Journal of Cancer
Volume39
Issue number7
Publication statusPublished - May-2003

    Keywords

  • multidrug resistance, P-gp, MRP1, LRP, sarcoma, GASTROINTESTINAL STROMAL TUMORS, PROGNOSTIC FACTORS, GLYCOPROTEIN EXPRESSION, EUROPEAN-ORGANIZATION, DRUG-RESISTANCE, VAULT PROTEIN, CELL-LINES, CANCER, CHEMOTHERAPY, DOXORUBICIN

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