Expression of multidrug resistance proteins, P-gp, MRP1 and LRP, in soft tissue sarcomas analysed according to their histological type and gradeKomdeur, R., Plaat, B. E. C., van der Graaf, W. T. A., Hoekstra, H. J., Hollema, H., van den Berg, E., Zwart, N., Scheper, R. J. & Molenaar, W. M., May-2003, In : European Journal of Cancer. 39, 7, p. 909-916 8 p.
Research output: Contribution to journal › Article › Academic › peer-review
The biological behaviour of different histological types and grades of soft tissue sarcomas (STS) varies. This might result in a differing sensitivity to cytotoxic drugs. Cross-resistance to functionally and structurally distinct natural-product drugs, known as multidrug resistance (MDR), is associated with the overexpression of P-glycoprotein (P-gp), multidrug resistance-associated protein I (MRP1) and lung resistance-related protein (LRP). The purpose of this study was to evaluate the expression of P-gp, MRP1 and LRP in STS according to their histological type and grade. In 141 chemotherapy-naive STS patients, the expression of the three MDR proteins was detected by immunohistochemistry. Nine histological types were documented. These were 19% grade 1, 34% grade 2 and 47% grade 3 tumours. Expression of P-gp and LRP was observed more frequently than the expression of MRP1 (P
|Number of pages||8|
|Journal||European Journal of Cancer|
|Publication status||Published - May-2003|
- multidrug resistance, P-gp, MRP1, LRP, sarcoma, GASTROINTESTINAL STROMAL TUMORS, PROGNOSTIC FACTORS, GLYCOPROTEIN EXPRESSION, EUROPEAN-ORGANIZATION, DRUG-RESISTANCE, VAULT PROTEIN, CELL-LINES, CANCER, CHEMOTHERAPY, DOXORUBICIN