Publication

Exposure to reactive intermediate-inducing drugs during pregnancy and the incident use of psychotropic medications among children

Tran, Y-H., Groen, H., Bergman, J. E. H., Hak, E. & Wilffert, B., Mar-2017, In : Pharmcoepidemiology and Drug Safety. 26, 3, p. 265-273 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Tran, Y-H., Groen, H., Bergman, J. E. H., Hak, E., & Wilffert, B. (2017). Exposure to reactive intermediate-inducing drugs during pregnancy and the incident use of psychotropic medications among children. Pharmcoepidemiology and Drug Safety, 26(3), 265-273. https://doi.org/10.1002/pds.4161

Author

Tran, Yen-Hao ; Groen, Henk ; Bergman, Jorieke E H ; Hak, Eelko ; Wilffert, Bob. / Exposure to reactive intermediate-inducing drugs during pregnancy and the incident use of psychotropic medications among children. In: Pharmcoepidemiology and Drug Safety. 2017 ; Vol. 26, No. 3. pp. 265-273.

Harvard

Tran, Y-H, Groen, H, Bergman, JEH, Hak, E & Wilffert, B 2017, 'Exposure to reactive intermediate-inducing drugs during pregnancy and the incident use of psychotropic medications among children' Pharmcoepidemiology and Drug Safety, vol. 26, no. 3, pp. 265-273. https://doi.org/10.1002/pds.4161

Standard

Exposure to reactive intermediate-inducing drugs during pregnancy and the incident use of psychotropic medications among children. / Tran, Yen-Hao; Groen, Henk; Bergman, Jorieke E H; Hak, Eelko; Wilffert, Bob.

In: Pharmcoepidemiology and Drug Safety, Vol. 26, No. 3, 03.2017, p. 265-273.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Tran Y-H, Groen H, Bergman JEH, Hak E, Wilffert B. Exposure to reactive intermediate-inducing drugs during pregnancy and the incident use of psychotropic medications among children. Pharmcoepidemiology and Drug Safety. 2017 Mar;26(3):265-273. https://doi.org/10.1002/pds.4161


BibTeX

@article{704767e6b56c402abce4212c80fbe0e4,
title = "Exposure to reactive intermediate-inducing drugs during pregnancy and the incident use of psychotropic medications among children",
abstract = "Purpose Our study aimed to investigate the association between prenatal exposure to reactive intermediate (RI)-inducing drugs and the initiation of psychotropic medications among children.Methods We designed a cohort study using a pharmacy prescription database. Pregnant women were considered exposed when they received a prescription of RI-inducing drugs. These drugs could be either used alone (-I+/FAA-) or combined with drugs exhibiting folic acid antagonism (FAA, RI+/FAA+). The reference group included pregnant women who did not receive any RI-inducing drugs or FAA drugs.Results We analyzed 4116 exposed and 30 422 reference pregnancies. The hazard ratio (HR) with 95{\%} confidence interval (CI) was 1.27 (95{\%} CI 1.15-1.41) for pregnancies exposed to RI-inducing drugs as a whole. Considering subgroups of RI-inducing drugs, prenatal exposure to both RI+/FAA+ and RI+/FAA- was associated with the children's initiation of psychotropic medications, HRs being 1.35 (95{\%} CI 1.10-1.66) and 1.26 (1.13-1.41), respectively. The HRs were increased with prolonged exposure to RI-inducing drugs, especially in the first and second trimesters. In a detailed examination of the psychotropics, the incidences of receiving antimigraine preparations and psychostimulants were significantly increased for the exposed children, compared with the reference children. The incidences of receiving antipsychotics and hypnotics were also higher for the exposed children; however, the HRs did not reach significance after adjustment.Conclusions We found a significantly increased incident use of psychotropic medications among children prenatally exposed to RI-inducing drugs, especially during the first and second trimesters. This suggests a detrimental effect during critical periods of brain development. Copyright (C) 2017 John Wiley & Sons, Ltd.",
keywords = "reactive intermediates, folic acid antagonism, pregnancy, drug exposure, psychotropic medications, pharmacoepidemiology, OXIDATIVE STRESS, FOLIC-ACID, SCHIZOPHRENIA, EVENTS, BRAIN",
author = "Yen-Hao Tran and Henk Groen and Bergman, {Jorieke E H} and Eelko Hak and Bob Wilffert",
note = "Copyright {\circledC} 2017 John Wiley & Sons, Ltd.",
year = "2017",
month = "3",
doi = "10.1002/pds.4161",
language = "English",
volume = "26",
pages = "265--273",
journal = "Pharmcoepidemiology and Drug Safety",
issn = "1053-8569",
publisher = "WILEY",
number = "3",

}

RIS

TY - JOUR

T1 - Exposure to reactive intermediate-inducing drugs during pregnancy and the incident use of psychotropic medications among children

AU - Tran, Yen-Hao

AU - Groen, Henk

AU - Bergman, Jorieke E H

AU - Hak, Eelko

AU - Wilffert, Bob

N1 - Copyright © 2017 John Wiley & Sons, Ltd.

PY - 2017/3

Y1 - 2017/3

N2 - Purpose Our study aimed to investigate the association between prenatal exposure to reactive intermediate (RI)-inducing drugs and the initiation of psychotropic medications among children.Methods We designed a cohort study using a pharmacy prescription database. Pregnant women were considered exposed when they received a prescription of RI-inducing drugs. These drugs could be either used alone (-I+/FAA-) or combined with drugs exhibiting folic acid antagonism (FAA, RI+/FAA+). The reference group included pregnant women who did not receive any RI-inducing drugs or FAA drugs.Results We analyzed 4116 exposed and 30 422 reference pregnancies. The hazard ratio (HR) with 95% confidence interval (CI) was 1.27 (95% CI 1.15-1.41) for pregnancies exposed to RI-inducing drugs as a whole. Considering subgroups of RI-inducing drugs, prenatal exposure to both RI+/FAA+ and RI+/FAA- was associated with the children's initiation of psychotropic medications, HRs being 1.35 (95% CI 1.10-1.66) and 1.26 (1.13-1.41), respectively. The HRs were increased with prolonged exposure to RI-inducing drugs, especially in the first and second trimesters. In a detailed examination of the psychotropics, the incidences of receiving antimigraine preparations and psychostimulants were significantly increased for the exposed children, compared with the reference children. The incidences of receiving antipsychotics and hypnotics were also higher for the exposed children; however, the HRs did not reach significance after adjustment.Conclusions We found a significantly increased incident use of psychotropic medications among children prenatally exposed to RI-inducing drugs, especially during the first and second trimesters. This suggests a detrimental effect during critical periods of brain development. Copyright (C) 2017 John Wiley & Sons, Ltd.

AB - Purpose Our study aimed to investigate the association between prenatal exposure to reactive intermediate (RI)-inducing drugs and the initiation of psychotropic medications among children.Methods We designed a cohort study using a pharmacy prescription database. Pregnant women were considered exposed when they received a prescription of RI-inducing drugs. These drugs could be either used alone (-I+/FAA-) or combined with drugs exhibiting folic acid antagonism (FAA, RI+/FAA+). The reference group included pregnant women who did not receive any RI-inducing drugs or FAA drugs.Results We analyzed 4116 exposed and 30 422 reference pregnancies. The hazard ratio (HR) with 95% confidence interval (CI) was 1.27 (95% CI 1.15-1.41) for pregnancies exposed to RI-inducing drugs as a whole. Considering subgroups of RI-inducing drugs, prenatal exposure to both RI+/FAA+ and RI+/FAA- was associated with the children's initiation of psychotropic medications, HRs being 1.35 (95% CI 1.10-1.66) and 1.26 (1.13-1.41), respectively. The HRs were increased with prolonged exposure to RI-inducing drugs, especially in the first and second trimesters. In a detailed examination of the psychotropics, the incidences of receiving antimigraine preparations and psychostimulants were significantly increased for the exposed children, compared with the reference children. The incidences of receiving antipsychotics and hypnotics were also higher for the exposed children; however, the HRs did not reach significance after adjustment.Conclusions We found a significantly increased incident use of psychotropic medications among children prenatally exposed to RI-inducing drugs, especially during the first and second trimesters. This suggests a detrimental effect during critical periods of brain development. Copyright (C) 2017 John Wiley & Sons, Ltd.

KW - reactive intermediates

KW - folic acid antagonism

KW - pregnancy

KW - drug exposure

KW - psychotropic medications

KW - pharmacoepidemiology

KW - OXIDATIVE STRESS

KW - FOLIC-ACID

KW - SCHIZOPHRENIA

KW - EVENTS

KW - BRAIN

U2 - 10.1002/pds.4161

DO - 10.1002/pds.4161

M3 - Article

VL - 26

SP - 265

EP - 273

JO - Pharmcoepidemiology and Drug Safety

JF - Pharmcoepidemiology and Drug Safety

SN - 1053-8569

IS - 3

ER -

ID: 39735604