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Exposure to Endocrine Disrupting Chemicals in the Dutch general population is associated with adiposity-related traits

van der Meer, T. P., van Faassen, M., van Beek, A. P., Snieder, H., Kema, I. P., Wolffenbuttel, B. H. R. & van Vliet-Ostaptchouk, J. V., 9-Jun-2020, In : Scientific Reports. 10, 1, 10 p., 9311.

Research output: Contribution to journalArticleAcademicpeer-review

Endocrine Disrupting Chemicals (EDCs) have been linked to a variety of cardiometabolic diseases. Yet, few studies have investigated the exposure to EDCs and cardiometabolic health taking lifestyle into account. We aimed to assess exposure to five parabens, three bisphenols and thirteen metabolites of in total eight phthalates in a general Dutch population and to investigate their association with cardiometabolic traits. In 662 adult subjects from the population-based Lifelines cohort, 21 EDC analytes were measured in 24-hour urine collected in 2012, using LC-MS/MS. Association analyses between cardiometabolic traits and EDC concentrations were performed using multivariate linear models adjusting for age, sex, education, smoking, diabetes, physical activity and caloric intake. Quartile analyses were performed to assess linearity. Bisphenol A, four parabens and eight phthalate metabolites were detected in 84-100% of the samples. Adjusted associations for MiBP and MBzP and adiposity-related traits were robust for multiple testing (Beta's, BMI: 1.12, 2.52; waist circumference: 0.64, 1.56, respectively; FDR

Original languageEnglish
Article number9311
Number of pages10
JournalScientific Reports
Volume10
Issue number1
Publication statusPublished - 9-Jun-2020

    Keywords

  • URINARY PHTHALATE METABOLITES, BISPHENOL-A CONCENTRATION, DUISBURG BIRTH COHORT, MOTHER-CHILD-PAIRS, PREGNANT-WOMEN, ENVIRONMENTAL CHEMICALS, INSULIN-RESISTANCE, TEMPORAL TRENDS, PARABENS, EXCRETION

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