Publication

Exponential self-replication enabled through a fibre elongation/breakage mechanism

Colomb-Delsuc, M., Mattia, E., Sadownik, J. W. & Otto, S., 2015, In : Nature Communications. 6, 7 p., 7427.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Colomb-Delsuc, M., Mattia, E., Sadownik, J. W., & Otto, S. (2015). Exponential self-replication enabled through a fibre elongation/breakage mechanism. Nature Communications, 6, [7427]. https://doi.org/10.1038/ncomms8427

Author

Colomb-Delsuc, Mathieu ; Mattia, Elio ; Sadownik, Jan W ; Otto, Sijbren. / Exponential self-replication enabled through a fibre elongation/breakage mechanism. In: Nature Communications. 2015 ; Vol. 6.

Harvard

Colomb-Delsuc, M, Mattia, E, Sadownik, JW & Otto, S 2015, 'Exponential self-replication enabled through a fibre elongation/breakage mechanism', Nature Communications, vol. 6, 7427. https://doi.org/10.1038/ncomms8427

Standard

Exponential self-replication enabled through a fibre elongation/breakage mechanism. / Colomb-Delsuc, Mathieu; Mattia, Elio; Sadownik, Jan W; Otto, Sijbren.

In: Nature Communications, Vol. 6, 7427, 2015.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Colomb-Delsuc M, Mattia E, Sadownik JW, Otto S. Exponential self-replication enabled through a fibre elongation/breakage mechanism. Nature Communications. 2015;6. 7427. https://doi.org/10.1038/ncomms8427


BibTeX

@article{e35863af43dc421e99b137254d435229,
title = "Exponential self-replication enabled through a fibre elongation/breakage mechanism",
abstract = "Self-replicating molecules are likely to have played a central role in the origin of life. Most scenarios of Darwinian evolution at the molecular level require self-replicators capable of exponential growth, yet only very few exponential replicators have been reported to date and general design criteria for exponential replication are lacking. Here we show that a peptide-functionalized macrocyclic self-replicator exhibits exponential growth when subjected to mild agitation. The replicator self-assembles into elongated fibres of which the ends promote replication and fibre growth. Agitation results in breakage of the growing fibres, generating more fibre ends. Our data suggest a mechanism in which mechanical energy promotes the liberation of the replicator from the inactive self-assembled state, thereby overcoming self-inhibition that prevents the majority of self-replicating molecules developed to date from attaining exponential growth.",
author = "Mathieu Colomb-Delsuc and Elio Mattia and Sadownik, {Jan W} and Sijbren Otto",
year = "2015",
doi = "10.1038/ncomms8427",
language = "English",
volume = "6",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Exponential self-replication enabled through a fibre elongation/breakage mechanism

AU - Colomb-Delsuc, Mathieu

AU - Mattia, Elio

AU - Sadownik, Jan W

AU - Otto, Sijbren

PY - 2015

Y1 - 2015

N2 - Self-replicating molecules are likely to have played a central role in the origin of life. Most scenarios of Darwinian evolution at the molecular level require self-replicators capable of exponential growth, yet only very few exponential replicators have been reported to date and general design criteria for exponential replication are lacking. Here we show that a peptide-functionalized macrocyclic self-replicator exhibits exponential growth when subjected to mild agitation. The replicator self-assembles into elongated fibres of which the ends promote replication and fibre growth. Agitation results in breakage of the growing fibres, generating more fibre ends. Our data suggest a mechanism in which mechanical energy promotes the liberation of the replicator from the inactive self-assembled state, thereby overcoming self-inhibition that prevents the majority of self-replicating molecules developed to date from attaining exponential growth.

AB - Self-replicating molecules are likely to have played a central role in the origin of life. Most scenarios of Darwinian evolution at the molecular level require self-replicators capable of exponential growth, yet only very few exponential replicators have been reported to date and general design criteria for exponential replication are lacking. Here we show that a peptide-functionalized macrocyclic self-replicator exhibits exponential growth when subjected to mild agitation. The replicator self-assembles into elongated fibres of which the ends promote replication and fibre growth. Agitation results in breakage of the growing fibres, generating more fibre ends. Our data suggest a mechanism in which mechanical energy promotes the liberation of the replicator from the inactive self-assembled state, thereby overcoming self-inhibition that prevents the majority of self-replicating molecules developed to date from attaining exponential growth.

U2 - 10.1038/ncomms8427

DO - 10.1038/ncomms8427

M3 - Article

VL - 6

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 7427

ER -

ID: 24178201