Exploring the theme: Synthesis and biological properties of tridentate cyclometalated gold(III) complexesJuergens, S., Scalcon, V., Estrada-Ortiz, N., Folda, A., Tonolo, F., Jandl, C., Browne, D. L., Rigobello, M. P., Kuehn, F. E. & Casini, A., 15-Oct-2017, In : Bioorganic & Medicinal Chemistry. 25, 20, p. 5452-5460 9 p.
Research output: Contribution to journal › Article › Academic › peer-review
A family of cyclometalated Au(III) complexes featuring a tridentate CNC scaffold has been synthesized and characterized. Microwave assisted synthesis of the ligands has also been exploited and optimized. The biological properties of the thus formed compounds have been studied in cancer cells and demonstrate generally moderate antiproliferative effects. Initial mechanistic insights have also been gained on the gold complex [Au(CNC)(GluS)] (3), and support the idea that the thioredoxin system may be a target for this family of compounds together with other relevant intracellular thiol-containing molecules. (C) 2017 Elsevier Ltd. All rights reserved.
|Number of pages||9|
|Journal||Bioorganic & Medicinal Chemistry|
|Publication status||Published - 15-Oct-2017|
- Gold(III) complexes, Cyclometalation, Anticancer agents, Thioredoxin reductase, Thiols, TRANSITION-METAL-COMPLEXES, HETEROCYCLIC CARBENE COMPLEXES, ANTIPROLIFERATIVE PROPERTIES, THIOREDOXIN REDUCTASE, CYTOTOXIC PROPERTIES, ANTICANCER AGENTS, CHEMISTRY, GOLD, PURIFICATION, SYSTEM