Publication

Exploring the theme: Synthesis and biological properties of tridentate cyclometalated gold(III) complexes

Juergens, S., Scalcon, V., Estrada-Ortiz, N., Folda, A., Tonolo, F., Jandl, C., Browne, D. L., Rigobello, M. P., Kuehn, F. E. & Casini, A., 15-Oct-2017, In : Bioorganic & Medicinal Chemistry. 25, 20, p. 5452-5460 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Copy link to clipboard

Documents

  • Exploring the theme

    Final publisher's version, 796 KB, PDF document

    Request copy

DOI

  • Sophie Juergens
  • Valeria Scalcon
  • Natalia Estrada-Ortiz
  • Alessandra Folda
  • Federica Tonolo
  • Christian Jandl
  • Duncan L. Browne
  • Maria Pia Rigobello
  • Fritz E. Kuehn
  • Angela Casini

A family of cyclometalated Au(III) complexes featuring a tridentate CNC scaffold has been synthesized and characterized. Microwave assisted synthesis of the ligands has also been exploited and optimized. The biological properties of the thus formed compounds have been studied in cancer cells and demonstrate generally moderate antiproliferative effects. Initial mechanistic insights have also been gained on the gold complex [Au(CNC)(GluS)] (3), and support the idea that the thioredoxin system may be a target for this family of compounds together with other relevant intracellular thiol-containing molecules. (C) 2017 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)5452-5460
Number of pages9
JournalBioorganic & Medicinal Chemistry
Volume25
Issue number20
Publication statusPublished - 15-Oct-2017

    Keywords

  • Gold(III) complexes, Cyclometalation, Anticancer agents, Thioredoxin reductase, Thiols, TRANSITION-METAL-COMPLEXES, HETEROCYCLIC CARBENE COMPLEXES, ANTIPROLIFERATIVE PROPERTIES, THIOREDOXIN REDUCTASE, CYTOTOXIC PROPERTIES, ANTICANCER AGENTS, CHEMISTRY, GOLD, PURIFICATION, SYSTEM

View graph of relations

ID: 97526816