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Exploring multicomponent reactions: From chemistry to drug design

Kroon, E. 2017 [Groningen]: Rijksuniversiteit Groningen. 141 p.

Research output: ScientificDoctoral Thesis

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  • Edwin Kroon
The nature of the starting materials allow multicomponent reactions to be versatile alternatives to classical chemical synthesis in the preparation of complex organic molecules or pharmaceutical products. The reason why multicomponent reactions have required so much attention is the fact that they have some advantages over classical chemical methods. They exhibit a remarkable atom economy, are efficient, are well suited for parallel synthesis allowing for the generation of large libraries, and the number of compounds that can be formed is enormous.
Many aspects of cell life are regulated through protein phosphorylation, a process that is carried out by kinases. Their main function is signal transduction within cells by alteration of substrate activity, protein kinases also govern many other cellular processes. The family of AGC kinases plays a significant role in regulating physiological processes relevant to metabolism, growth, proliferation and survival, therefore dysregulation can have great consequences. Two main diseases associated with dysregulation in these physiological processes are cancer and diabetes mellitus type 2, on the other hand, mutations have been shown to cause various inherited syndromes.
The research in this thesis is focused on the application of new starting materials in multicomponent reactions and on the development of small molecules that target the kinase PDK1.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
Supervisors/Advisors
Award date17-Feb-2017
Place of Publication[Groningen]
Publisher
Print ISBNs978-90-367-9543-2
Electronic ISBNs978-90-367-9542-5
StatePublished - 2017

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