Publication

Evidence for the hallmarks of human aging in replicatively aging yeast

Janssens, G. E. & Veenhoff, L. M., Jul-2016, In : Microbial Cell. 3, 7, p. 263-274 12 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Recently, efforts have been made to characterize the hallmarks that accompany and contribute to the phenomenon of aging, as most relevant for humans [1]. Remarkably, studying the finite lifespan of the single cell eukaryote budding yeast (recently reviewed in [2] and [3]) has been paramount for our understanding of aging. Here, we compile observations from literature over the past decades of research on replicatively aging yeast to highlight how the hallmarks of aging in humans are present in yeast. We find strong evidence for the majority of these, and summarize how yeast aging is especially characterized by the hallmarks of genomic instability, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, and mitochondrial dysfunction.

Original languageEnglish
Pages (from-to)263-274
Number of pages12
JournalMicrobial Cell
Volume3
Issue number7
Publication statusPublished - Jul-2016

    Keywords

  • hallmarks of aging, human, replicative aging, yeast, LIFE-SPAN EXTENSION, AGE-RELATED DISEASE, SACCHAROMYCES-CEREVISIAE, BUDDING YEAST, MOTHER CELLS, CALORIE RESTRICTION, CELLULAR SENESCENCE, GENOME INSTABILITY, DNA-DAMAGE, HISTONE H4

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