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Evaluation of macrolides for possible use against multidrug-resistant Mycobacterium tuberculosis

van der Paardt, A-F., Wilffert, B., Akkerman, O. W., de Lange, W. C. M., van Soolingen, D., Sinha, B., van der Werf, T. S., Kosterink, J. G. W. & Alffenaar, J-W. C., Aug-2015, In : European Respiratory Journal. 46, 2, p. 444-455 12 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Multidrug-resistant tuberculosis (MDR-TB) is a major global health problem. The loss of susceptibility to an increasing number of drugs behoves us to consider the evaluation of non-traditional anti-tuberculosis drugs.

Clarithromycin, a macrolide antibiotic, is defined as a group 5 anti-tuberculosis drug by the World Health Organization; however, its role or efficacy in the treatment of MDR-TB is unclear. A systematic review of the literature was conducted to summarise the evidence for the activity of macrolides against MDR-TB, by evaluating in vitro, in vivo and clinical studies. PubMed and Embase were searched for English language articles up to May 2014.

Even though high minimum inhibitory concentration values are usually found, suggesting low activity against Mycobacterium tuberculosis, the potential benefits of macrolides are their accumulation in the relevant compartments and cells in the lungs, their immunomodulatory effects and their synergistic activity with other anti-TB drugs.

A future perspective may be use of more potent macrolide analogues to enhance the activity of the treatment regimen.

Original languageEnglish
Pages (from-to)444-455
Number of pages12
JournalEuropean Respiratory Journal
Volume46
Issue number2
Publication statusPublished - Aug-2015

    Keywords

  • IN-VITRO ACTIVITY, ANTIMICROBIAL AGENTS, DRUG-RESISTANCE, STRUCTURAL BASIS, AVIUM COMPLEX, INTRACELLULAR ACTIVITIES, PULMONARY TUBERCULOSIS, SYNERGISTIC ACTIVITIES, BACTERICIDAL ACTIVITY, RIBOSOMAL-SUBUNIT

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