Evaluating the use of optimally respiratory gated 18F-FDG-PET in target volume delineation and its influence on radiation doses to the organs at risk in non-small-cell lung cancer patients

Wijsman, R., Grootjans, W., Troost, E. G., Van Der Heijden, E. H., Visser, E. P., De Geus-Oei, L-F. & Bussink, J., 13-Feb-2016, In : Nuclear Medicine Communications. 37, 1, p. 66-73 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • Robin Wijsman
  • Willem Grootjans
  • Esther G. Troost
  • Erik H Van Der Heijden
  • Eric P. Visser
  • Lioe-Fee De Geus-Oei
  • Johan Bussink
Objective This radiotherapy planning study evaluated tumour delineation using both optimally respiratory gated and nongated fluorine-18 fluorodeoxyglucose-PET (18F-FDG-PET). Methods For 22 non-small-cell lung tumours, both scans were used to create the nongated and gated (g) gross tumour volumes (GTVg) together with the accompanying clinical target volumes (CTV) and planning target volumes (PTV). The size of the target volumes (TV) was evaluated and the accompanying radiotherapy plans were created to study the radiation doses to the organs at risk (OAR). Results The median volumes of GTVg, CTVg and PTVg were statistically significantly smaller compared with the corresponding nongated volumes, resulting in a median TV reduction of 0.5 cm3 (interquartile range 0.1-1.2), 1.5 cm3 (-0.2 to 7.0) and 2.3 cm3 (-0.5 to 11.3) for the GTVg, CTVg and PTVg, respectively. For the OAR, only the percentage of lung (GTV included) receiving at least 35 Gy was significantly smaller after gating, with a median difference in lung volume receiving at least 35 Gy of 5.7 cm3 (interquartile range -0.8 to 30.50). Conclusion Compared with nongated 18F-FDG-PET, the TVs obtained with optimally respiratory gated 18F-FDG-PET were significantly smaller, however, without a clinically relevant difference in radiation dose to the OAR. Nucl Med Commun 37:66-73
Original languageEnglish
Pages (from-to)66-73
Number of pages8
JournalNuclear Medicine Communications
Issue number1
Publication statusPublished - 13-Feb-2016


  • 18F-FDG-PET, non-small-cell lung cancer, radiotherapy, respiratory gating, fluorine 18, article, clinical article, human, lung volume, non small cell lung cancer, organs at risk, PET-CT scanner, radiation dose, radiation dose distribution, respiratory gated imaging, retrospective study, total lung capacity, treatment planning, tumor volume

ID: 54254652