Publication

Estimating the population-level effectiveness of vaccination program in the Netherlands

van Wijhe, M., McDonald, S. A., de Melker, H. E., Postma, M. J. & Wallinga, J., Mar-2018, In : Epidemiology. 29, 2, p. 215-223 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

van Wijhe, M., McDonald, S. A., de Melker, H. E., Postma, M. J., & Wallinga, J. (2018). Estimating the population-level effectiveness of vaccination program in the Netherlands. Epidemiology, 29(2), 215-223. https://doi.org/10.1097/EDE.0000000000000778

Author

van Wijhe, Maarten ; McDonald, Scott A ; de Melker, Hester E ; Postma, Maarten J ; Wallinga, Jacco. / Estimating the population-level effectiveness of vaccination program in the Netherlands. In: Epidemiology. 2018 ; Vol. 29, No. 2. pp. 215-223.

Harvard

van Wijhe, M, McDonald, SA, de Melker, HE, Postma, MJ & Wallinga, J 2018, 'Estimating the population-level effectiveness of vaccination program in the Netherlands', Epidemiology, vol. 29, no. 2, pp. 215-223. https://doi.org/10.1097/EDE.0000000000000778

Standard

Estimating the population-level effectiveness of vaccination program in the Netherlands. / van Wijhe, Maarten; McDonald, Scott A; de Melker, Hester E; Postma, Maarten J; Wallinga, Jacco.

In: Epidemiology, Vol. 29, No. 2, 03.2018, p. 215-223.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

van Wijhe M, McDonald SA, de Melker HE, Postma MJ, Wallinga J. Estimating the population-level effectiveness of vaccination program in the Netherlands. Epidemiology. 2018 Mar;29(2):215-223. https://doi.org/10.1097/EDE.0000000000000778


BibTeX

@article{b891ab3f4e664f888716098ed9a0d5e9,
title = "Estimating the population-level effectiveness of vaccination program in the Netherlands",
abstract = "BACKGROUND: There are few estimates of the effectiveness of long-standing vaccination programs in developed countries. To fill this gap, we investigate the direct and indirect effectiveness of childhood vaccination programs on mortality at the population level in the Netherlands.METHODS: We focused on three communicable infectious diseases, diphtheria, pertussis, and poliomyelitis, for which we expect both direct and indirect effects. As a negative control, we used tetanus, a non-communicable infectious disease for which only direct effects are anticipated. Mortality data from 1903-2012 were obtained from Statistics Netherlands. Vaccination coverage data were obtained from various official reports. For the birth cohorts 1903 through 1975, all-cause and cause-specific childhood mortality burden was estimated using restricted mean lifetime survival methods, and a model was used to describe the pre-vaccination decline in burden. By projecting model results into the vaccination era, we obtained the expected burden without vaccination. Program effectiveness was estimated as the difference between observed and expected mortality burden.RESULTS: Each vaccination program showed a high overall effectiveness, increasing to nearly 100% within ten birth cohorts. For diphtheria, 14.9% (95% uncertainty interval [UI]: 12.3%, 17.6%) of mortality burden averted by vaccination was due to indirect protection. For pertussis, this was 32.1% (95% UI: 31.3%, 32.8%). No indirect effects were observed for poliomyelitis or tetanus with -2.4% (UI: -16.7%, 7.1%) and 0.6% (UI: -17.9%, 10.7%) respectively.CONCLUSION: Vaccination programs for diphtheria and pertussis showed substantial indirect effects, providing evidence for herd protection.",
keywords = "Journal Article, DESIGNS, IMPACT, C CONJUGATE VACCINATION, LIFE YEARS LOST, HERD-IMMUNITY, INFANT IMMUNIZATION, MORTALITY, VACCINES, CHILDREN, EFFICACY",
author = "{van Wijhe}, Maarten and McDonald, {Scott A} and {de Melker}, {Hester E} and Postma, {Maarten J} and Jacco Wallinga",
year = "2018",
month = mar,
doi = "10.1097/EDE.0000000000000778",
language = "English",
volume = "29",
pages = "215--223",
journal = "Epidemiology",
issn = "1044-3983",
publisher = "LIPPINCOTT WILLIAMS & WILKINS",
number = "2",

}

RIS

TY - JOUR

T1 - Estimating the population-level effectiveness of vaccination program in the Netherlands

AU - van Wijhe, Maarten

AU - McDonald, Scott A

AU - de Melker, Hester E

AU - Postma, Maarten J

AU - Wallinga, Jacco

PY - 2018/3

Y1 - 2018/3

N2 - BACKGROUND: There are few estimates of the effectiveness of long-standing vaccination programs in developed countries. To fill this gap, we investigate the direct and indirect effectiveness of childhood vaccination programs on mortality at the population level in the Netherlands.METHODS: We focused on three communicable infectious diseases, diphtheria, pertussis, and poliomyelitis, for which we expect both direct and indirect effects. As a negative control, we used tetanus, a non-communicable infectious disease for which only direct effects are anticipated. Mortality data from 1903-2012 were obtained from Statistics Netherlands. Vaccination coverage data were obtained from various official reports. For the birth cohorts 1903 through 1975, all-cause and cause-specific childhood mortality burden was estimated using restricted mean lifetime survival methods, and a model was used to describe the pre-vaccination decline in burden. By projecting model results into the vaccination era, we obtained the expected burden without vaccination. Program effectiveness was estimated as the difference between observed and expected mortality burden.RESULTS: Each vaccination program showed a high overall effectiveness, increasing to nearly 100% within ten birth cohorts. For diphtheria, 14.9% (95% uncertainty interval [UI]: 12.3%, 17.6%) of mortality burden averted by vaccination was due to indirect protection. For pertussis, this was 32.1% (95% UI: 31.3%, 32.8%). No indirect effects were observed for poliomyelitis or tetanus with -2.4% (UI: -16.7%, 7.1%) and 0.6% (UI: -17.9%, 10.7%) respectively.CONCLUSION: Vaccination programs for diphtheria and pertussis showed substantial indirect effects, providing evidence for herd protection.

AB - BACKGROUND: There are few estimates of the effectiveness of long-standing vaccination programs in developed countries. To fill this gap, we investigate the direct and indirect effectiveness of childhood vaccination programs on mortality at the population level in the Netherlands.METHODS: We focused on three communicable infectious diseases, diphtheria, pertussis, and poliomyelitis, for which we expect both direct and indirect effects. As a negative control, we used tetanus, a non-communicable infectious disease for which only direct effects are anticipated. Mortality data from 1903-2012 were obtained from Statistics Netherlands. Vaccination coverage data were obtained from various official reports. For the birth cohorts 1903 through 1975, all-cause and cause-specific childhood mortality burden was estimated using restricted mean lifetime survival methods, and a model was used to describe the pre-vaccination decline in burden. By projecting model results into the vaccination era, we obtained the expected burden without vaccination. Program effectiveness was estimated as the difference between observed and expected mortality burden.RESULTS: Each vaccination program showed a high overall effectiveness, increasing to nearly 100% within ten birth cohorts. For diphtheria, 14.9% (95% uncertainty interval [UI]: 12.3%, 17.6%) of mortality burden averted by vaccination was due to indirect protection. For pertussis, this was 32.1% (95% UI: 31.3%, 32.8%). No indirect effects were observed for poliomyelitis or tetanus with -2.4% (UI: -16.7%, 7.1%) and 0.6% (UI: -17.9%, 10.7%) respectively.CONCLUSION: Vaccination programs for diphtheria and pertussis showed substantial indirect effects, providing evidence for herd protection.

KW - Journal Article

KW - DESIGNS

KW - IMPACT

KW - C CONJUGATE VACCINATION

KW - LIFE YEARS LOST

KW - HERD-IMMUNITY

KW - INFANT IMMUNIZATION

KW - MORTALITY

KW - VACCINES

KW - CHILDREN

KW - EFFICACY

U2 - 10.1097/EDE.0000000000000778

DO - 10.1097/EDE.0000000000000778

M3 - Article

C2 - 29087989

VL - 29

SP - 215

EP - 223

JO - Epidemiology

JF - Epidemiology

SN - 1044-3983

IS - 2

ER -

ID: 49760674