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Estimating the population-level effectiveness of vaccination program in the Netherlands
van Wijhe, M., McDonald, S. A., de Melker, H. E., Postma, M. J. & Wallinga, J., Mar-2018, In : Epidemiology. 29, 2, p. 215-223 9 p.Research output: Contribution to journal › Article › Academic › peer-review
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Estimating the population-level effectiveness of vaccination program in the Netherlands. / van Wijhe, Maarten; McDonald, Scott A; de Melker, Hester E; Postma, Maarten J; Wallinga, Jacco.
In: Epidemiology, Vol. 29, No. 2, 03.2018, p. 215-223.Research output: Contribution to journal › Article › Academic › peer-review
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TY - JOUR
T1 - Estimating the population-level effectiveness of vaccination program in the Netherlands
AU - van Wijhe, Maarten
AU - McDonald, Scott A
AU - de Melker, Hester E
AU - Postma, Maarten J
AU - Wallinga, Jacco
PY - 2018/3
Y1 - 2018/3
N2 - BACKGROUND: There are few estimates of the effectiveness of long-standing vaccination programs in developed countries. To fill this gap, we investigate the direct and indirect effectiveness of childhood vaccination programs on mortality at the population level in the Netherlands.METHODS: We focused on three communicable infectious diseases, diphtheria, pertussis, and poliomyelitis, for which we expect both direct and indirect effects. As a negative control, we used tetanus, a non-communicable infectious disease for which only direct effects are anticipated. Mortality data from 1903-2012 were obtained from Statistics Netherlands. Vaccination coverage data were obtained from various official reports. For the birth cohorts 1903 through 1975, all-cause and cause-specific childhood mortality burden was estimated using restricted mean lifetime survival methods, and a model was used to describe the pre-vaccination decline in burden. By projecting model results into the vaccination era, we obtained the expected burden without vaccination. Program effectiveness was estimated as the difference between observed and expected mortality burden.RESULTS: Each vaccination program showed a high overall effectiveness, increasing to nearly 100% within ten birth cohorts. For diphtheria, 14.9% (95% uncertainty interval [UI]: 12.3%, 17.6%) of mortality burden averted by vaccination was due to indirect protection. For pertussis, this was 32.1% (95% UI: 31.3%, 32.8%). No indirect effects were observed for poliomyelitis or tetanus with -2.4% (UI: -16.7%, 7.1%) and 0.6% (UI: -17.9%, 10.7%) respectively.CONCLUSION: Vaccination programs for diphtheria and pertussis showed substantial indirect effects, providing evidence for herd protection.
AB - BACKGROUND: There are few estimates of the effectiveness of long-standing vaccination programs in developed countries. To fill this gap, we investigate the direct and indirect effectiveness of childhood vaccination programs on mortality at the population level in the Netherlands.METHODS: We focused on three communicable infectious diseases, diphtheria, pertussis, and poliomyelitis, for which we expect both direct and indirect effects. As a negative control, we used tetanus, a non-communicable infectious disease for which only direct effects are anticipated. Mortality data from 1903-2012 were obtained from Statistics Netherlands. Vaccination coverage data were obtained from various official reports. For the birth cohorts 1903 through 1975, all-cause and cause-specific childhood mortality burden was estimated using restricted mean lifetime survival methods, and a model was used to describe the pre-vaccination decline in burden. By projecting model results into the vaccination era, we obtained the expected burden without vaccination. Program effectiveness was estimated as the difference between observed and expected mortality burden.RESULTS: Each vaccination program showed a high overall effectiveness, increasing to nearly 100% within ten birth cohorts. For diphtheria, 14.9% (95% uncertainty interval [UI]: 12.3%, 17.6%) of mortality burden averted by vaccination was due to indirect protection. For pertussis, this was 32.1% (95% UI: 31.3%, 32.8%). No indirect effects were observed for poliomyelitis or tetanus with -2.4% (UI: -16.7%, 7.1%) and 0.6% (UI: -17.9%, 10.7%) respectively.CONCLUSION: Vaccination programs for diphtheria and pertussis showed substantial indirect effects, providing evidence for herd protection.
KW - Journal Article
KW - DESIGNS
KW - IMPACT
KW - C CONJUGATE VACCINATION
KW - LIFE YEARS LOST
KW - HERD-IMMUNITY
KW - INFANT IMMUNIZATION
KW - MORTALITY
KW - VACCINES
KW - CHILDREN
KW - EFFICACY
U2 - 10.1097/EDE.0000000000000778
DO - 10.1097/EDE.0000000000000778
M3 - Article
C2 - 29087989
VL - 29
SP - 215
EP - 223
JO - Epidemiology
JF - Epidemiology
SN - 1044-3983
IS - 2
ER -
ID: 49760674