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ESTER OF GLUCURONIDE PRODRUG OF ANTHRACYCLINE AND METHOD OF PREPARATION AND USE IN TUMOR-SELECTIVE CHEMOTHERAPY

ABEN RENE WILHELMUS, MARIE., SCHEEREN JOHAN, WILHELM., CORNELISSEN JEROEN JOHANNES LAMBERTUS, MARIA., DE VOS, DICK. & Haisma, H., 24-Sep-2009, IPC No. C07H 15/ 26 A I, Patent No. JP2009215295, Priority date 7-Mar-2008, Priority No. EP20080004249

Research output: PatentProfessional

  • MARIE ABEN RENE WILHELMUS (Inventor)
  • WILHELM SCHEEREN JOHAN (Inventor)
  • MARIA CORNELISSEN JEROEN JOHANNES LAMBERTUS (Inventor)
  • DICK DE VOS (Inventor)
  • Hidde Haisma (Inventor)

PROBLEM TO BE SOLVED: To provide an anthracycline prodrug useful as an antitumor agent and an efficient method for preparing the anthracycline prodrug. ;SOLUTION: A method in which protection of sugar hydroxy groups is not required in the final step (the coupling of the glucuronide spacer unit to the parent drug molecule) in the synthesis of the prodrug, some new ester syntheses of water-soluble anthracycline glucuronide prodrugs using the method, and use of the anthracycline glucuronide prodrugs in tumor-selective chemotherapy are provided. ;COPYRIGHT: (C)2009,JPO&INPIT

Original languageEnglish
Patent numberJP2009215295
IPCC07H 15/ 26 A I
Priority date07/03/2008
Publication statusPublished - 24-Sep-2009

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