Erythroid progenitors from patients with low-risk myelodysplastic syndromes are dependent on the surrounding micro environment for their survivalFolkerts, H., Hazenberg, C. L. E., Houwerzijl, E. J., van den Heuvel, F. A. J., Mulder, A. B., van der Want, J. J. L. & Vellenga, E., Mar-2015, In : Experimental Hematology. 43, 3, p. 215-222.e2 10 p.
Research output: Contribution to journal › Article › Academic › peer-review
To investigate whether the type of programmed cell death of myelodysplastic erythroid cells depends on their cellular context, we performed studies on cells from patients with low-risk myelodysplastic syndromes. We compared erythroid cells (and their precursor cells) from the mononuclear cell fraction with those from the hematon fraction, which are compacted complexes of hematopoietic cells surrounded by their own micro-environment. In directly fixed materials, erythroblasts exhibited signs of autophagy with limited apoptosis (
|Number of pages||10|
|Publication status||Published - Mar-2015|
- MESENCHYMAL STROMAL CELLS, ACUTE MYELOID-LEUKEMIA, BONE-MARROW, ENHANCED AUTOPHAGY, STEM-CELL, MEGAKARYOCYTES, PRECURSORS, HEMATON, UNIT