Epithelial cell-cell junctions and plasma membrane domains

Giepmans, B. N. G. & van Ijzendoorn, S. C. D., Apr-2009, In : Biochimica et Biophysica Acta-Biomembranes. 1788, 4, p. 820-831 12 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Epithelial cells form a barrier against the environment, but are also required for the regulated exchange of molecules between an organism and its surroundings. Epithelial cells are characterised by a remarkable polarization of their plasma membrane, evidenced by the appearance of structurally, compositionally, and functionally distinct surface domains. Here we consider the (in)dependence of epithelial cell polarisation and the function of smaller plasma membrane domains (e.g. adherens junctions, gap junctions, tight junctions, apical lipid rafts, caveolae, and clathrin-coated pits) in the development and maintenance of cell surface polarity. Recent evidence of cross-talk and/or overlap between the different cell-cell junction components and alternate functions of junction components, including gene expression regulation, are discussed in the context of cell surface polarity. (C) 2008 Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)820-831
Number of pages12
JournalBiochimica et Biophysica Acta-Biomembranes
Issue number4
Publication statusPublished - Apr-2009


  • Cell-cell junctions, Cell polarity, Tight junctions, Adherens junctions, Gap junctions, Lipid rafts, Caveolae, Clathrin-coated pits, Tetraspannin-enriched microdomains, TRANSCRIPTION FACTOR ZONAB/DBPA, CD44 VARIANT ISOFORMS, CANINE KIDNEY-CELLS, TIGHT JUNCTIONS, E-CADHERIN, ADHERENS JUNCTIONS, ADHESION MOLECULE, GAP-JUNCTIONS, PROTEIN ZO-2, MDCK CELLS

ID: 4887920