Publication

Epigenetic Mechanisms Facilitating Oligodendrocyte Development, Maturation, and Aging

Copray, S., Huynh, J. L., Sher, F., Casaccia-Bonnefil, P. & Boddeke, E., 15-Nov-2009, In : Glia. 57, 15, p. 1579-1587 9 p.

Research output: Contribution to journalReview articleAcademicpeer-review

  • Sjef Copray
  • Jimmy Long Huynh
  • Falak Sher
  • Patrizia Casaccia-Bonnefil
  • Erik Boddeke

The process of oligodendrocyte differentiation is regulated by a dynamic interaction between a genetic and an epigenetic program. Recent studies, addressing nucleosomal histone modifications have considerably increased our knowledge regarding epigenetic regulation of gene expression during oligodendrocyte development and aging. These results have generated new hypotheses regarding the mechanisms underlying the decreased efficiency of endogenous remyelination in response to demyelinating injuries with increasing age. In this review, we present an overview of the epigenetic mechanisms regulating gene expression at specific stages of oligodendrocyte differentiation and maturation as well as the changes that occur with aging. (C) 2009 Wiley-Liss, Inc.

Original languageEnglish
Pages (from-to)1579-1587
Number of pages9
JournalGlia
Volume57
Issue number15
Publication statusPublished - 15-Nov-2009

    Keywords

  • histone modification, oligodendrocyte differentiation, microRNA, multiple sclerosis, MYELIN BASIC-PROTEIN, HISTONE DEACETYLASE ACTIVITY, EMBRYONIC STEM-CELLS, MULTIPLE-SCLEROSIS, GENE-EXPRESSION, PRECURSOR CELLS, PROGENITOR DIFFERENTIATION, TRANSCRIPTIONAL CONTROL, SPINAL-CORD, POSTTRANSLATIONAL MODIFICATIONS

ID: 4971780