Epigenetic editing of DNA Methylation and DeRewriting DNA Methylation Signatures at Will: The Curable Genome Within Reach?

Stolzenburg, S., Goubert, D. & Rots, M., 2016, DNA Methyltransferases - Role and Function. Springer, p. 475-490 535 p.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

DNA methyltransferases are important enzymes in a broad range of organisms. Dysfunction of DNA methyltransferases in humans leads to many severe diseases, including cancer. This book focuses on the biochemical properties of these enzymes, describing their structures and mechanisms in bacteria, humans and other species, including plants, and also explains the biological processes of reading of DNA methylation and DNA demethylation. It covers many emerging aspects of the biological roles of DNA methylation functioning as an essential epigenetic mark and describes the role of DNA methylation in diseases. Moreover, the book explains modern technologies, like targeted rewriting of DNA methylation by designed DNA methyltransferases, as well as technological applications of DNA methyltransferases in DNA labelling. Finally, the book summarizes recent methods for the analysis of DNA methylation in human DNA. Overall, this book represents a comprehensive state-of-the-art- work and is a must-have for advanced researchers in the field of DNA methylation and epigenetics.
Original languageEnglish
Title of host publicationDNA Methyltransferases - Role and Function
Number of pages535
ISBN (Electronic)978-3-319-43624-1
Publication statusPublished - 2016

ID: 61151062