Epidemiological and clinical profile of infective endocarditis at a Brazilian tertiary care center: an eight-year prospective studyDamasco, P. V., Correal, J. C. D., Cruz-Campos, A. C. D., Wajsbrot, B. R., Cunha, R. G. D., Fonseca, A. G. D., Castier, M. B., Fortes, C. Q., Jazbick, J. C., Lemos, E. R. S. D., Rossen, J. W., Leão, R. D. S., Hirata Junior, R. & Guaraldi, A. L. D. M., 6-Jun-2019, In : Revista da Sociedade Brasileira de Medicina Tropical. 52, 9 p., e2018375.
Research output: Contribution to journal › Article › Academic › peer-review
INTRODUCTION: Infective endocarditis (IE) is a systemic infectious disease requiring a multidisciplinary team for treatment. This study presents the epidemiological and clinical data of 73 cases of IE in Rio de Janeiro, Brazil.
METHODS: This observational prospective cohort study of endocarditis patients during an eight-year study period described 73 episodes of IE in 70 patients (three had IE twice). Community-associated (CAIE) and healthcare-acquired infective endocarditis (HAIE) were diagnosed according to the modified Duke criteria. The collected data included demographic, epidemiologic, and clinical characteristics, including results of blood cultures, echocardiographic findings, surgical interventions, and outcome.
RESULTS: Analysis of data from the eight-year study period and 73 cases (70 patients) of IE showed a mean age of 46 years (SD=2.5 years; 1-84 years) and that 65.7% were male patients. The prevalence of CAIE and HAIE was 32.9% and 67.1%, respectively. Staphylococcus aureus (30.1%), Enterococcus spp. (19.1%), and Streptococcus spp. (15.0%) were the prevalent microorganisms. The relevant signals and symptoms were fever (97.2%; mean 38.6 + 0.05°C) and heart murmur (87.6%). Vegetations were observed in the mitral (41.1%) and aortic (27.4%) valves. The mortality rate of the cases was 47.9%.
CONCLUSIONS: In multivariate analysis, chronic renal failure (relative risk [RR]= 1.60; 95% confidence interval [CI] 1.01-2.55), septic shock (RR= 2.19; 95% CI 1.499-3.22), and age over 60 years (RR= 2.28; 95% CI 1.44-3.59) were indirectly associated with in-hospital mortality. The best prognosis was related to the performance of cardiovascular surgery (hazard ratio [HR]= 0.51; 95% CI 0.26-0.99).
|Number of pages||9|
|Journal||Revista da Sociedade Brasileira de Medicina Tropical|
|Publication status||E-pub ahead of print - 6-Jun-2019|
- Infectious endocarditis; HAIE; CAIE; Staphylococcus aureus; Enterococcus spp.; Streptococcus spp.