Publication

Epidemic of carbapenem-resistant Klebsiella pneumoniae in Europe is driven by nosocomial spread

EuSCAPE Working Group, David, S., Reuter, S., Harris, S. R., Glasner, C., Feltwell, T., Argimon, S., Abudahab, K., Goater, R., Giani, T., Errico, G., Aspbury, M., Sjunnebo, S., Feil, E. J., Rossolini, G. M., Aanensen, D. M. & Grundmann, H., Nov-2019, In : Nature Microbiology. 4, 11, p. 1919-1929 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

EuSCAPE Working Group, David, S., Reuter, S., Harris, S. R., Glasner, C., Feltwell, T., ... Grundmann, H. (2019). Epidemic of carbapenem-resistant Klebsiella pneumoniae in Europe is driven by nosocomial spread. Nature Microbiology, 4(11), 1919-1929. https://doi.org/10.1038/s41564-019-0492-8

Author

EuSCAPE Working Group ; David, Sophia ; Reuter, Sandra ; Harris, Simon R ; Glasner, Corinna ; Feltwell, Theresa ; Argimon, Silvia ; Abudahab, Khalil ; Goater, Richard ; Giani, Tommaso ; Errico, Giulia ; Aspbury, Marianne ; Sjunnebo, Sara ; Feil, Edward J ; Rossolini, Gian Maria ; Aanensen, David M ; Grundmann, Hajo. / Epidemic of carbapenem-resistant Klebsiella pneumoniae in Europe is driven by nosocomial spread. In: Nature Microbiology. 2019 ; Vol. 4, No. 11. pp. 1919-1929.

Harvard

EuSCAPE Working Group, David, S, Reuter, S, Harris, SR, Glasner, C, Feltwell, T, Argimon, S, Abudahab, K, Goater, R, Giani, T, Errico, G, Aspbury, M, Sjunnebo, S, Feil, EJ, Rossolini, GM, Aanensen, DM & Grundmann, H 2019, 'Epidemic of carbapenem-resistant Klebsiella pneumoniae in Europe is driven by nosocomial spread', Nature Microbiology, vol. 4, no. 11, pp. 1919-1929. https://doi.org/10.1038/s41564-019-0492-8

Standard

Epidemic of carbapenem-resistant Klebsiella pneumoniae in Europe is driven by nosocomial spread. / EuSCAPE Working Group; David, Sophia; Reuter, Sandra; Harris, Simon R; Glasner, Corinna; Feltwell, Theresa; Argimon, Silvia; Abudahab, Khalil; Goater, Richard; Giani, Tommaso; Errico, Giulia; Aspbury, Marianne; Sjunnebo, Sara; Feil, Edward J; Rossolini, Gian Maria; Aanensen, David M; Grundmann, Hajo.

In: Nature Microbiology, Vol. 4, No. 11, 11.2019, p. 1919-1929.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

EuSCAPE Working Group, David S, Reuter S, Harris SR, Glasner C, Feltwell T et al. Epidemic of carbapenem-resistant Klebsiella pneumoniae in Europe is driven by nosocomial spread. Nature Microbiology. 2019 Nov;4(11):1919-1929. https://doi.org/10.1038/s41564-019-0492-8


BibTeX

@article{36a5af0d4242405ba6aef1b9a3b8f0e4,
title = "Epidemic of carbapenem-resistant Klebsiella pneumoniae in Europe is driven by nosocomial spread",
abstract = "Public health interventions to control the current epidemic of carbapenem-resistant Klebsiella pneumoniae rely on a comprehensive understanding of its emergence and spread over a wide range of geographical scales. We analysed the genome sequences and epidemiological data of >1,700 K. pneumoniae samples isolated from patients in 244 hospitals in 32 countries during the European Survey of Carbapenemase-Producing Enterobacteriaceae. We demonstrate that carbapenemase acquisition is the main cause of carbapenem resistance and that it occurred across diverse phylogenetic backgrounds. However, 477 of 682 (69.9{\%}) carbapenemase-positive isolates are concentrated in four clonal lineages, sequence types 11, 15, 101, 258/512 and their derivatives. Combined analysis of the genetic and geographic distances between isolates with different β-lactam resistance determinants suggests that the propensity of K. pneumoniae to spread in hospital environments correlates with the degree of resistance and that carbapenemase-positive isolates have the highest transmissibility. Indeed, we found that over half of the hospitals that contributed carbapenemase-positive isolates probably experienced within-hospital transmission, and interhospital spread is far more frequent within, rather than between, countries. Finally, we propose a value of 21 for the number of single nucleotide polymorphisms that optimizes the discrimination of hospital clusters and detail the international spread of the successful epidemic lineage, ST258/512.",
author = "{EuSCAPE Working Group} and Sophia David and Sandra Reuter and Harris, {Simon R} and Corinna Glasner and Theresa Feltwell and Silvia Argimon and Khalil Abudahab and Richard Goater and Tommaso Giani and Giulia Errico and Marianne Aspbury and Sara Sjunnebo and Feil, {Edward J} and Rossolini, {Gian Maria} and Aanensen, {David M} and Hajo Grundmann",
year = "2019",
month = "11",
doi = "10.1038/s41564-019-0492-8",
language = "English",
volume = "4",
pages = "1919--1929",
journal = "Nature Microbiology",
issn = "2058-5276",
publisher = "Nature Publishing Group",
number = "11",

}

RIS

TY - JOUR

T1 - Epidemic of carbapenem-resistant Klebsiella pneumoniae in Europe is driven by nosocomial spread

AU - EuSCAPE Working Group

AU - David, Sophia

AU - Reuter, Sandra

AU - Harris, Simon R

AU - Glasner, Corinna

AU - Feltwell, Theresa

AU - Argimon, Silvia

AU - Abudahab, Khalil

AU - Goater, Richard

AU - Giani, Tommaso

AU - Errico, Giulia

AU - Aspbury, Marianne

AU - Sjunnebo, Sara

AU - Feil, Edward J

AU - Rossolini, Gian Maria

AU - Aanensen, David M

AU - Grundmann, Hajo

PY - 2019/11

Y1 - 2019/11

N2 - Public health interventions to control the current epidemic of carbapenem-resistant Klebsiella pneumoniae rely on a comprehensive understanding of its emergence and spread over a wide range of geographical scales. We analysed the genome sequences and epidemiological data of >1,700 K. pneumoniae samples isolated from patients in 244 hospitals in 32 countries during the European Survey of Carbapenemase-Producing Enterobacteriaceae. We demonstrate that carbapenemase acquisition is the main cause of carbapenem resistance and that it occurred across diverse phylogenetic backgrounds. However, 477 of 682 (69.9%) carbapenemase-positive isolates are concentrated in four clonal lineages, sequence types 11, 15, 101, 258/512 and their derivatives. Combined analysis of the genetic and geographic distances between isolates with different β-lactam resistance determinants suggests that the propensity of K. pneumoniae to spread in hospital environments correlates with the degree of resistance and that carbapenemase-positive isolates have the highest transmissibility. Indeed, we found that over half of the hospitals that contributed carbapenemase-positive isolates probably experienced within-hospital transmission, and interhospital spread is far more frequent within, rather than between, countries. Finally, we propose a value of 21 for the number of single nucleotide polymorphisms that optimizes the discrimination of hospital clusters and detail the international spread of the successful epidemic lineage, ST258/512.

AB - Public health interventions to control the current epidemic of carbapenem-resistant Klebsiella pneumoniae rely on a comprehensive understanding of its emergence and spread over a wide range of geographical scales. We analysed the genome sequences and epidemiological data of >1,700 K. pneumoniae samples isolated from patients in 244 hospitals in 32 countries during the European Survey of Carbapenemase-Producing Enterobacteriaceae. We demonstrate that carbapenemase acquisition is the main cause of carbapenem resistance and that it occurred across diverse phylogenetic backgrounds. However, 477 of 682 (69.9%) carbapenemase-positive isolates are concentrated in four clonal lineages, sequence types 11, 15, 101, 258/512 and their derivatives. Combined analysis of the genetic and geographic distances between isolates with different β-lactam resistance determinants suggests that the propensity of K. pneumoniae to spread in hospital environments correlates with the degree of resistance and that carbapenemase-positive isolates have the highest transmissibility. Indeed, we found that over half of the hospitals that contributed carbapenemase-positive isolates probably experienced within-hospital transmission, and interhospital spread is far more frequent within, rather than between, countries. Finally, we propose a value of 21 for the number of single nucleotide polymorphisms that optimizes the discrimination of hospital clusters and detail the international spread of the successful epidemic lineage, ST258/512.

U2 - 10.1038/s41564-019-0492-8

DO - 10.1038/s41564-019-0492-8

M3 - Article

VL - 4

SP - 1919

EP - 1929

JO - Nature Microbiology

JF - Nature Microbiology

SN - 2058-5276

IS - 11

ER -

ID: 93998100