Publication

Epicardial fat in heart failure patients with mid-range and preserved ejection fraction

van Woerden, G., Gorter, T. M., Westenbrink, B. D., Willems, T. P., van Veldhuisen, D. J. & Rienstra, M., Nov-2018, In : European Journal of Heart Failure. 20, 11, p. 1559-1566 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

van Woerden, G., Gorter, T. M., Westenbrink, B. D., Willems, T. P., van Veldhuisen, D. J., & Rienstra, M. (2018). Epicardial fat in heart failure patients with mid-range and preserved ejection fraction. European Journal of Heart Failure, 20(11), 1559-1566. https://doi.org/10.1002/ejhf.1283

Author

van Woerden, Gijs ; Gorter, Thomas M ; Westenbrink, B Daan ; Willems, Tineke P ; van Veldhuisen, Dirk J ; Rienstra, Michiel. / Epicardial fat in heart failure patients with mid-range and preserved ejection fraction. In: European Journal of Heart Failure. 2018 ; Vol. 20, No. 11. pp. 1559-1566.

Harvard

van Woerden, G, Gorter, TM, Westenbrink, BD, Willems, TP, van Veldhuisen, DJ & Rienstra, M 2018, 'Epicardial fat in heart failure patients with mid-range and preserved ejection fraction', European Journal of Heart Failure, vol. 20, no. 11, pp. 1559-1566. https://doi.org/10.1002/ejhf.1283

Standard

Epicardial fat in heart failure patients with mid-range and preserved ejection fraction. / van Woerden, Gijs; Gorter, Thomas M; Westenbrink, B Daan; Willems, Tineke P; van Veldhuisen, Dirk J; Rienstra, Michiel.

In: European Journal of Heart Failure, Vol. 20, No. 11, 11.2018, p. 1559-1566.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

van Woerden G, Gorter TM, Westenbrink BD, Willems TP, van Veldhuisen DJ, Rienstra M. Epicardial fat in heart failure patients with mid-range and preserved ejection fraction. European Journal of Heart Failure. 2018 Nov;20(11):1559-1566. https://doi.org/10.1002/ejhf.1283


BibTeX

@article{ad9f352ef72d43ffb4935f6029cfff78,
title = "Epicardial fat in heart failure patients with mid-range and preserved ejection fraction",
abstract = "AIMS: Adipose tissue and inflammation may play a role in the pathophysiology of patients with heart failure (HF) with mildly reduced or preserved ejection fraction. We therefore investigated epicardial fat in patients with HF with preserved (HFpEF) and mid-range ejection fraction (HFmrEF), and related this to co-morbidities, plasma biomarkers and cardiac structure.METHODS AND RESULTS: A total of 64 HF patients with left ventricular ejection fraction >40{\%} and 20 controls underwent routine cardiac magnetic resonance examination. Epicardial fat volume was quantified on short-axis cine stacks covering the entire epicardium and was related to clinical correlates, biomarkers associated with inflammation and myocardial injury, and cardiac function and contractility on cardiac magnetic resonance. HF patients and controls were of comparable age, sex and body mass index. Total epicardial fat volume was significantly higher in HF patients compared to controls (107 mL/m2 vs. 77 mL/m2 , P <0.0001). HF patients with atrial fibrillation and/or type 2 diabetes mellitus had more epicardial fat than HF patients without these co-morbidities (116 vs. 100 mL/m2 , P =0.03, and 120 vs. 97 mL/m2 , P =0.001, respectively). Creatine kinase-MB, troponin T and glycated haemoglobin in patients with HF were positively correlated with epicardial fat volume (R =0.37, P =0.006; R =0.35, P =0.01; and R =0.42, P =0.002, respectively).CONCLUSION: Heart failure patients had more epicardial fat compared to controls, despite similar body mass index. Epicardial fat volume was associated with the presence of atrial fibrillation and type 2 diabetes mellitus and with biomarkers related to myocardial injury. The clinical implications of these findings are unclear, but warrant further investigation.",
keywords = "Heart failure with preserved ejection fraction, Heart failure with mid-range ejection fraction, Epicardial fat, Atrial fibrillation, Cardiac magnetic resonance imaging, ADIPOSE-TISSUE, CARDIOMETABOLIC RISK, PERICARDIAL FAT, PHENOTYPE, OBESITY, MRI",
author = "{van Woerden}, Gijs and Gorter, {Thomas M} and Westenbrink, {B Daan} and Willems, {Tineke P} and {van Veldhuisen}, {Dirk J} and Michiel Rienstra",
note = "{\circledC} 2018 The Authors. European Journal of Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.",
year = "2018",
month = "11",
doi = "10.1002/ejhf.1283",
language = "English",
volume = "20",
pages = "1559--1566",
journal = "European Journal of Heart Failure",
issn = "1388-9842",
publisher = "Wiley",
number = "11",

}

RIS

TY - JOUR

T1 - Epicardial fat in heart failure patients with mid-range and preserved ejection fraction

AU - van Woerden, Gijs

AU - Gorter, Thomas M

AU - Westenbrink, B Daan

AU - Willems, Tineke P

AU - van Veldhuisen, Dirk J

AU - Rienstra, Michiel

N1 - © 2018 The Authors. European Journal of Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.

PY - 2018/11

Y1 - 2018/11

N2 - AIMS: Adipose tissue and inflammation may play a role in the pathophysiology of patients with heart failure (HF) with mildly reduced or preserved ejection fraction. We therefore investigated epicardial fat in patients with HF with preserved (HFpEF) and mid-range ejection fraction (HFmrEF), and related this to co-morbidities, plasma biomarkers and cardiac structure.METHODS AND RESULTS: A total of 64 HF patients with left ventricular ejection fraction >40% and 20 controls underwent routine cardiac magnetic resonance examination. Epicardial fat volume was quantified on short-axis cine stacks covering the entire epicardium and was related to clinical correlates, biomarkers associated with inflammation and myocardial injury, and cardiac function and contractility on cardiac magnetic resonance. HF patients and controls were of comparable age, sex and body mass index. Total epicardial fat volume was significantly higher in HF patients compared to controls (107 mL/m2 vs. 77 mL/m2 , P <0.0001). HF patients with atrial fibrillation and/or type 2 diabetes mellitus had more epicardial fat than HF patients without these co-morbidities (116 vs. 100 mL/m2 , P =0.03, and 120 vs. 97 mL/m2 , P =0.001, respectively). Creatine kinase-MB, troponin T and glycated haemoglobin in patients with HF were positively correlated with epicardial fat volume (R =0.37, P =0.006; R =0.35, P =0.01; and R =0.42, P =0.002, respectively).CONCLUSION: Heart failure patients had more epicardial fat compared to controls, despite similar body mass index. Epicardial fat volume was associated with the presence of atrial fibrillation and type 2 diabetes mellitus and with biomarkers related to myocardial injury. The clinical implications of these findings are unclear, but warrant further investigation.

AB - AIMS: Adipose tissue and inflammation may play a role in the pathophysiology of patients with heart failure (HF) with mildly reduced or preserved ejection fraction. We therefore investigated epicardial fat in patients with HF with preserved (HFpEF) and mid-range ejection fraction (HFmrEF), and related this to co-morbidities, plasma biomarkers and cardiac structure.METHODS AND RESULTS: A total of 64 HF patients with left ventricular ejection fraction >40% and 20 controls underwent routine cardiac magnetic resonance examination. Epicardial fat volume was quantified on short-axis cine stacks covering the entire epicardium and was related to clinical correlates, biomarkers associated with inflammation and myocardial injury, and cardiac function and contractility on cardiac magnetic resonance. HF patients and controls were of comparable age, sex and body mass index. Total epicardial fat volume was significantly higher in HF patients compared to controls (107 mL/m2 vs. 77 mL/m2 , P <0.0001). HF patients with atrial fibrillation and/or type 2 diabetes mellitus had more epicardial fat than HF patients without these co-morbidities (116 vs. 100 mL/m2 , P =0.03, and 120 vs. 97 mL/m2 , P =0.001, respectively). Creatine kinase-MB, troponin T and glycated haemoglobin in patients with HF were positively correlated with epicardial fat volume (R =0.37, P =0.006; R =0.35, P =0.01; and R =0.42, P =0.002, respectively).CONCLUSION: Heart failure patients had more epicardial fat compared to controls, despite similar body mass index. Epicardial fat volume was associated with the presence of atrial fibrillation and type 2 diabetes mellitus and with biomarkers related to myocardial injury. The clinical implications of these findings are unclear, but warrant further investigation.

KW - Heart failure with preserved ejection fraction

KW - Heart failure with mid-range ejection fraction

KW - Epicardial fat

KW - Atrial fibrillation

KW - Cardiac magnetic resonance imaging

KW - ADIPOSE-TISSUE

KW - CARDIOMETABOLIC RISK

KW - PERICARDIAL FAT

KW - PHENOTYPE

KW - OBESITY

KW - MRI

U2 - 10.1002/ejhf.1283

DO - 10.1002/ejhf.1283

M3 - Article

C2 - 30070041

VL - 20

SP - 1559

EP - 1566

JO - European Journal of Heart Failure

JF - European Journal of Heart Failure

SN - 1388-9842

IS - 11

ER -

ID: 65264767