Publication

ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries

ENIGMA Consortium, 20-Mar-2020, In : Translational Psychiatry. 10, 1, 100.

Research output: Contribution to journalReview articleAcademicpeer-review

APA

ENIGMA Consortium (2020). ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries. Translational Psychiatry, 10(1), [100]. https://doi.org/10.1038/s41398-020-0705-1

Author

ENIGMA Consortium. / ENIGMA and global neuroscience : A decade of large-scale studies of the brain in health and disease across more than 40 countries. In: Translational Psychiatry. 2020 ; Vol. 10, No. 1.

Harvard

ENIGMA Consortium 2020, 'ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries', Translational Psychiatry, vol. 10, no. 1, 100. https://doi.org/10.1038/s41398-020-0705-1

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ENIGMA and global neuroscience : A decade of large-scale studies of the brain in health and disease across more than 40 countries. / ENIGMA Consortium.

In: Translational Psychiatry, Vol. 10, No. 1, 100, 20.03.2020.

Research output: Contribution to journalReview articleAcademicpeer-review

Vancouver

ENIGMA Consortium. ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries. Translational Psychiatry. 2020 Mar 20;10(1). 100. https://doi.org/10.1038/s41398-020-0705-1


BibTeX

@article{8a4eedb0b72e4a54a31d0e3ecf6c6ce9,
title = "ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries",
abstract = "This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in health and disease. Building on large-scale genetic studies that discovered the first robustly replicated genetic loci associated with brain metrics, ENIGMA has diversified into over 50 working groups (WGs), pooling worldwide data and expertise to answer fundamental questions in neuroscience, psychiatry, neurology, and genetics. Most ENIGMA WGs focus on specific psychiatric and neurological conditions, other WGs study normal variation due to sex and gender differences, or development and aging; still other WGs develop methodological pipelines and tools to facilitate harmonized analyses of {"}big data{"} (i.e., genetic and epigenetic data, multimodal MRI, and electroencephalography data). These international efforts have yielded the largest neuroimaging studies to date in schizophrenia, bipolar disorder, major depressive disorder, post-traumatic stress disorder, substance use disorders, obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, autism spectrum disorders, epilepsy, and 22q11.2 deletion syndrome. More recent ENIGMA WGs have formed to study anxiety disorders, suicidal thoughts and behavior, sleep and insomnia, eating disorders, irritability, brain injury, antisocial personality and conduct disorder, and dissociative identity disorder. Here, we summarize the first decade of ENIGMA's activities and ongoing projects, and describe the successes and challenges encountered along the way. We highlight the advantages of collaborative large-scale coordinated data analyses for testing reproducibility and robustness of findings, offering the opportunity to identify brain systems involved in clinical syndromes across diverse samples and associated genetic, environmental, demographic, cognitive, and psychosocial factors.",
author = "{ENIGMA Consortium} and Thompson, {Paul M} and Neda Jahanshad and Ching, {Christopher R K} and Salminen, {Lauren E} and Thomopoulos, {Sophia I} and Joanna Bright and Baune, {Bernhard T} and Sara Bertol{\'i}n and Janita Bralten and Bruin, {Willem B} and Robin B{\"u}low and Jian Chen and Yann Chye and Udo Dannlowski and {de Kovel}, {Carolien G F} and Gary Donohoe and Eyler, {Lisa T} and Faraone, {Stephen V} and Pauline Favre and Filippi, {Courtney A} and Thomas Frodl and Daniel Garijo and Yolanda Gil and Grabe, {Hans J} and Grasby, {Katrina L} and Tomas Hajek and Han, {Laura K M} and Hatton, {Sean N} and Kevin Hilbert and Ho, {Tiffany C} and Laurena Holleran and Georg Homuth and Norbert Hosten and Josselin Houenou and Iliyan Ivanov and Tianye Jia and Sinead Kelly and Marieke Klein and Kwon, {Jun Soo} and Laansma, {Max A} and Jeanne Leerssen and Ulrike Lueken and Abraham Nunes and Neill, {Joseph O'} and Nils Opel and Lei Wang and Andr{\'e} Aleman and Groenewold, {Nynke A} and Lianne Schmaal and {van Rooij}, Daan",
year = "2020",
month = "3",
day = "20",
doi = "10.1038/s41398-020-0705-1",
language = "English",
volume = "10",
journal = "Translational Psychiatry",
issn = "2158-3188",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - ENIGMA and global neuroscience

T2 - A decade of large-scale studies of the brain in health and disease across more than 40 countries

AU - ENIGMA Consortium

AU - Thompson, Paul M

AU - Jahanshad, Neda

AU - Ching, Christopher R K

AU - Salminen, Lauren E

AU - Thomopoulos, Sophia I

AU - Bright, Joanna

AU - Baune, Bernhard T

AU - Bertolín, Sara

AU - Bralten, Janita

AU - Bruin, Willem B

AU - Bülow, Robin

AU - Chen, Jian

AU - Chye, Yann

AU - Dannlowski, Udo

AU - de Kovel, Carolien G F

AU - Donohoe, Gary

AU - Eyler, Lisa T

AU - Faraone, Stephen V

AU - Favre, Pauline

AU - Filippi, Courtney A

AU - Frodl, Thomas

AU - Garijo, Daniel

AU - Gil, Yolanda

AU - Grabe, Hans J

AU - Grasby, Katrina L

AU - Hajek, Tomas

AU - Han, Laura K M

AU - Hatton, Sean N

AU - Hilbert, Kevin

AU - Ho, Tiffany C

AU - Holleran, Laurena

AU - Homuth, Georg

AU - Hosten, Norbert

AU - Houenou, Josselin

AU - Ivanov, Iliyan

AU - Jia, Tianye

AU - Kelly, Sinead

AU - Klein, Marieke

AU - Kwon, Jun Soo

AU - Laansma, Max A

AU - Leerssen, Jeanne

AU - Lueken, Ulrike

AU - Nunes, Abraham

AU - Neill, Joseph O'

AU - Opel, Nils

AU - Wang, Lei

AU - Aleman, André

AU - Groenewold, Nynke A

AU - Schmaal, Lianne

AU - van Rooij, Daan

PY - 2020/3/20

Y1 - 2020/3/20

N2 - This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in health and disease. Building on large-scale genetic studies that discovered the first robustly replicated genetic loci associated with brain metrics, ENIGMA has diversified into over 50 working groups (WGs), pooling worldwide data and expertise to answer fundamental questions in neuroscience, psychiatry, neurology, and genetics. Most ENIGMA WGs focus on specific psychiatric and neurological conditions, other WGs study normal variation due to sex and gender differences, or development and aging; still other WGs develop methodological pipelines and tools to facilitate harmonized analyses of "big data" (i.e., genetic and epigenetic data, multimodal MRI, and electroencephalography data). These international efforts have yielded the largest neuroimaging studies to date in schizophrenia, bipolar disorder, major depressive disorder, post-traumatic stress disorder, substance use disorders, obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, autism spectrum disorders, epilepsy, and 22q11.2 deletion syndrome. More recent ENIGMA WGs have formed to study anxiety disorders, suicidal thoughts and behavior, sleep and insomnia, eating disorders, irritability, brain injury, antisocial personality and conduct disorder, and dissociative identity disorder. Here, we summarize the first decade of ENIGMA's activities and ongoing projects, and describe the successes and challenges encountered along the way. We highlight the advantages of collaborative large-scale coordinated data analyses for testing reproducibility and robustness of findings, offering the opportunity to identify brain systems involved in clinical syndromes across diverse samples and associated genetic, environmental, demographic, cognitive, and psychosocial factors.

AB - This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in health and disease. Building on large-scale genetic studies that discovered the first robustly replicated genetic loci associated with brain metrics, ENIGMA has diversified into over 50 working groups (WGs), pooling worldwide data and expertise to answer fundamental questions in neuroscience, psychiatry, neurology, and genetics. Most ENIGMA WGs focus on specific psychiatric and neurological conditions, other WGs study normal variation due to sex and gender differences, or development and aging; still other WGs develop methodological pipelines and tools to facilitate harmonized analyses of "big data" (i.e., genetic and epigenetic data, multimodal MRI, and electroencephalography data). These international efforts have yielded the largest neuroimaging studies to date in schizophrenia, bipolar disorder, major depressive disorder, post-traumatic stress disorder, substance use disorders, obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, autism spectrum disorders, epilepsy, and 22q11.2 deletion syndrome. More recent ENIGMA WGs have formed to study anxiety disorders, suicidal thoughts and behavior, sleep and insomnia, eating disorders, irritability, brain injury, antisocial personality and conduct disorder, and dissociative identity disorder. Here, we summarize the first decade of ENIGMA's activities and ongoing projects, and describe the successes and challenges encountered along the way. We highlight the advantages of collaborative large-scale coordinated data analyses for testing reproducibility and robustness of findings, offering the opportunity to identify brain systems involved in clinical syndromes across diverse samples and associated genetic, environmental, demographic, cognitive, and psychosocial factors.

U2 - 10.1038/s41398-020-0705-1

DO - 10.1038/s41398-020-0705-1

M3 - Review article

VL - 10

JO - Translational Psychiatry

JF - Translational Psychiatry

SN - 2158-3188

IS - 1

M1 - 100

ER -

ID: 121833971