Publication

Enhanced complement activation is part of the unfavourable cardiovascular risk profile in South Asians

Siezenga, M. A., Chandie Shaw, P. K., van der Geest, R. N., Mollnes, T. E., Daha, M. R., Rabelink, T. J. & Berger, S. P., Jul-2009, In : Clinical and Experimental Immunology. 157, 1, p. 98-103 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Copy link to clipboard

Documents

  • Enhanced complement activation is part of the unfavourable cardiovascular risk profile in South Asians

    Final publisher's version, 185 KB, PDF document

    Request copy

DOI

  • M A Siezenga
  • P K Chandie Shaw
  • R N van der Geest
  • T E Mollnes
  • M R Daha
  • T J Rabelink
  • S P Berger

South Asian immigrants in western societies exhibit a high burden of diabetes and subsequent vascular complications. Diabetic vascular complications are associated with vascular inflammation. We hypothesize that enhanced complement activation is involved. Therefore, levels of complement C3 and SC5b-9 - the soluble end product of complement activation - in a group of 200 South Asians were compared with an age- and sex-matched control group of native Caucasians. In addition, the association between complement levels and albuminuria, an indicator of renal damage and a cardiovascular risk marker, was assessed in the diabetic South Asian group. Compared with native Caucasians, South Asians had significantly higher levels of both serum C3 and plasma SC5b-9, even when only non-diabetic South Asians were considered. Diabetic South Asians had significantly higher C3 levels compared with non-diabetic South Asians. In diabetic South Asians, higher levels of SC5b-9 were associated with an increased prevalence of albuminuria (odds ratio 5.4, 95% confidence interval 1.8-15.8). These results suggest that enhanced complement activation is part of the unfavourable cardiovascular risk profile in South Asians.

Original languageEnglish
Pages (from-to)98-103
Number of pages6
JournalClinical and Experimental Immunology
Volume157
Issue number1
Publication statusPublished - Jul-2009
Externally publishedYes

    Keywords

  • Adult, Aged, Albuminuria, Asia, Southeastern, Asian Continental Ancestry Group, Biomarkers, Cardiovascular Diseases, Case-Control Studies, Complement Activation, Complement C3, Complement Membrane Attack Complex, Diabetes Mellitus, Type 2, Female, Humans, Male, Middle Aged, Netherlands, Risk, Statistics, Nonparametric, Comparative Study, Journal Article

ID: 53526611