Publication

Endothelial progenitor cell-based neovascularization: implications for therapy

Krenning, G., van Luyn, M. J. A. & Harmsen, M. C., Apr-2009, In : TRENDS IN MOLECULAR MEDICINE. 15, 4, p. 180-189 10 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Ischemic cardiovascular events are a major cause of death globally. Endothelial progenitor cell (EPC)-based approaches can result in improvement of vascular perfusion and might offer clinical benefit. However, although functional improvement is observed, the lack of long-term engraftment of EPCs into neovessels has raised controversy regarding their mechanism of action. We and others have hypothesized that after ischemic injury, EPCs induce neovascularization through the secretion of cytokines and growth factors, which act in a paracrine fashion and induce sprouting angiogenesis by the surrounding endothelium. In this concise review, we discuss the (patho)physiology of EPC-induced neovascularization and focus on the paracrine signals secreted by EPCs and the effects they elicit. In future therapies, clinical administration of these paracrine modulators using slow-release depots might induce neovascularization and might therefore hold promise for vascular regenerative medicine.

Original languageEnglish
Pages (from-to)180-189
Number of pages10
JournalTRENDS IN MOLECULAR MEDICINE
Volume15
Issue number4
Publication statusPublished - Apr-2009

    Keywords

  • ACUTE MYOCARDIAL-INFARCTION, UMBILICAL-CORD BLOOD, BONE-MARROW-CELLS, HUMAN CD34(+) CELLS, RANDOMIZED CONTROLLED-TRIAL, GROWTH-FACTOR DELIVERY, REPAIR-AMI TRIAL, IN-VITRO CULTURE, STEM-CELLS, POSTNATAL NEOVASCULARIZATION

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