Publication

Empirical support for the vascular apathy hypothesis: A structured review

Wouts, L., van Kessel, M., Beekman, A. T. F., Marijnissen, R. M. & Voshaar, R. C. O., 30-Oct-2019, In : International Journal of Geriatric Psychiatry. 35, 1, 9 p.

Research output: Contribution to journalReview articleAcademicpeer-review

APA

Wouts, L., van Kessel, M., Beekman, A. T. F., Marijnissen, R. M., & Voshaar, R. C. O. (2019). Empirical support for the vascular apathy hypothesis: A structured review. International Journal of Geriatric Psychiatry, 35(1). https://doi.org/10.1002/gps.5217

Author

Wouts, Lonneke ; van Kessel, Marco ; Beekman, Aartjan T. F. ; Marijnissen, Radboud M. ; Voshaar, Richard C. Oude. / Empirical support for the vascular apathy hypothesis : A structured review. In: International Journal of Geriatric Psychiatry. 2019 ; Vol. 35, No. 1.

Harvard

Wouts, L, van Kessel, M, Beekman, ATF, Marijnissen, RM & Voshaar, RCO 2019, 'Empirical support for the vascular apathy hypothesis: A structured review', International Journal of Geriatric Psychiatry, vol. 35, no. 1. https://doi.org/10.1002/gps.5217

Standard

Empirical support for the vascular apathy hypothesis : A structured review. / Wouts, Lonneke; van Kessel, Marco; Beekman, Aartjan T. F.; Marijnissen, Radboud M.; Voshaar, Richard C. Oude.

In: International Journal of Geriatric Psychiatry, Vol. 35, No. 1, 30.10.2019.

Research output: Contribution to journalReview articleAcademicpeer-review

Vancouver

Wouts L, van Kessel M, Beekman ATF, Marijnissen RM, Voshaar RCO. Empirical support for the vascular apathy hypothesis: A structured review. International Journal of Geriatric Psychiatry. 2019 Oct 30;35(1). https://doi.org/10.1002/gps.5217


BibTeX

@article{46f0aaa367484890ae57e04880303f25,
title = "Empirical support for the vascular apathy hypothesis: A structured review",
abstract = "Objectives A systematic review of the relationship between subclinical small vessel disease (SSVD) in the general population and apathy to examine the hypothesis that apathy has a vascular basis. Methods We searched for studies on associations between apathy and SSVD, operationalized as white matter hyperintensities (WMH) or white matter diffusivity changes, lacunar infarcts, cerebral microbleeds, decreasing cortical thickness, and perivascular spaces, while also peripheral proxies for SSVD were considered, operationalized as ankle brachial pressure index (ABI), intima media thickness, arterial stiffness, cardio-femoral pulse wave velocity, hypertension, or cardiovascular disease. Only eligible retrospective and prospective observational studies conducted in the general population were included. Results The 14 studies eligible for review examined the associations between apathy and hypertension (3), ABI (1), arterial stiffness (1), cardiovascular disease (2), WMH (3), white matter diffusivity (2), cerebral microbleeds (1), or cortical thickness (3). Arterial stiffness and white matter diffusivity were not related to apathy, while the associations with cortical thickness were contradictory. Cross-sectional studies in the general population did find evidence of apathy being associated with WMH, CM, cardiovascular disease, hypertension, and ABI, and cardiovascular disease was prospectively associated with apathy. The methodologies of the studies reviewed were too heterogeneous to perform meta-analyses. Conclusions Although more prospective evidence is needed and vascular depression needs to be controlled for, cardiovascular disease, hypertension, and ABI as proxies for SSVD, and WMH and cerebral microbleeds as direct measures of SSVD have been found to be associated with apathy in the general population, supporting the hypothesis of vascular apathy.",
keywords = "apathy, cerebrovascular disease, small vessel disease, vascular apathy, SMALL VESSEL DISEASE, INCIDENT CARDIOVASCULAR-DISEASE, MILD COGNITIVE IMPAIRMENT, DEPRESSION HYPOTHESIS, DIAGNOSTIC-CRITERIA, ALZHEIMERS-DISEASE, BLOOD-PRESSURE, OLDER PERSONS, SYMPTOMS, COMMUNITY",
author = "Lonneke Wouts and {van Kessel}, Marco and Beekman, {Aartjan T. F.} and Marijnissen, {Radboud M.} and Voshaar, {Richard C. Oude}",
year = "2019",
month = oct,
day = "30",
doi = "10.1002/gps.5217",
language = "English",
volume = "35",
journal = "International Journal of Geriatric Psychiatry",
issn = "0885-6230",
publisher = "Wiley",
number = "1",

}

RIS

TY - JOUR

T1 - Empirical support for the vascular apathy hypothesis

T2 - A structured review

AU - Wouts, Lonneke

AU - van Kessel, Marco

AU - Beekman, Aartjan T. F.

AU - Marijnissen, Radboud M.

AU - Voshaar, Richard C. Oude

PY - 2019/10/30

Y1 - 2019/10/30

N2 - Objectives A systematic review of the relationship between subclinical small vessel disease (SSVD) in the general population and apathy to examine the hypothesis that apathy has a vascular basis. Methods We searched for studies on associations between apathy and SSVD, operationalized as white matter hyperintensities (WMH) or white matter diffusivity changes, lacunar infarcts, cerebral microbleeds, decreasing cortical thickness, and perivascular spaces, while also peripheral proxies for SSVD were considered, operationalized as ankle brachial pressure index (ABI), intima media thickness, arterial stiffness, cardio-femoral pulse wave velocity, hypertension, or cardiovascular disease. Only eligible retrospective and prospective observational studies conducted in the general population were included. Results The 14 studies eligible for review examined the associations between apathy and hypertension (3), ABI (1), arterial stiffness (1), cardiovascular disease (2), WMH (3), white matter diffusivity (2), cerebral microbleeds (1), or cortical thickness (3). Arterial stiffness and white matter diffusivity were not related to apathy, while the associations with cortical thickness were contradictory. Cross-sectional studies in the general population did find evidence of apathy being associated with WMH, CM, cardiovascular disease, hypertension, and ABI, and cardiovascular disease was prospectively associated with apathy. The methodologies of the studies reviewed were too heterogeneous to perform meta-analyses. Conclusions Although more prospective evidence is needed and vascular depression needs to be controlled for, cardiovascular disease, hypertension, and ABI as proxies for SSVD, and WMH and cerebral microbleeds as direct measures of SSVD have been found to be associated with apathy in the general population, supporting the hypothesis of vascular apathy.

AB - Objectives A systematic review of the relationship between subclinical small vessel disease (SSVD) in the general population and apathy to examine the hypothesis that apathy has a vascular basis. Methods We searched for studies on associations between apathy and SSVD, operationalized as white matter hyperintensities (WMH) or white matter diffusivity changes, lacunar infarcts, cerebral microbleeds, decreasing cortical thickness, and perivascular spaces, while also peripheral proxies for SSVD were considered, operationalized as ankle brachial pressure index (ABI), intima media thickness, arterial stiffness, cardio-femoral pulse wave velocity, hypertension, or cardiovascular disease. Only eligible retrospective and prospective observational studies conducted in the general population were included. Results The 14 studies eligible for review examined the associations between apathy and hypertension (3), ABI (1), arterial stiffness (1), cardiovascular disease (2), WMH (3), white matter diffusivity (2), cerebral microbleeds (1), or cortical thickness (3). Arterial stiffness and white matter diffusivity were not related to apathy, while the associations with cortical thickness were contradictory. Cross-sectional studies in the general population did find evidence of apathy being associated with WMH, CM, cardiovascular disease, hypertension, and ABI, and cardiovascular disease was prospectively associated with apathy. The methodologies of the studies reviewed were too heterogeneous to perform meta-analyses. Conclusions Although more prospective evidence is needed and vascular depression needs to be controlled for, cardiovascular disease, hypertension, and ABI as proxies for SSVD, and WMH and cerebral microbleeds as direct measures of SSVD have been found to be associated with apathy in the general population, supporting the hypothesis of vascular apathy.

KW - apathy

KW - cerebrovascular disease

KW - small vessel disease

KW - vascular apathy

KW - SMALL VESSEL DISEASE

KW - INCIDENT CARDIOVASCULAR-DISEASE

KW - MILD COGNITIVE IMPAIRMENT

KW - DEPRESSION HYPOTHESIS

KW - DIAGNOSTIC-CRITERIA

KW - ALZHEIMERS-DISEASE

KW - BLOOD-PRESSURE

KW - OLDER PERSONS

KW - SYMPTOMS

KW - COMMUNITY

U2 - 10.1002/gps.5217

DO - 10.1002/gps.5217

M3 - Review article

VL - 35

JO - International Journal of Geriatric Psychiatry

JF - International Journal of Geriatric Psychiatry

SN - 0885-6230

IS - 1

ER -

ID: 118411883