Publication

Emerging Role of C/EBP beta and Epigenetic DNA Methylation in Ageing

Niehrs, C. & Calkhoven, C. F., Feb-2020, In : Trends in Genetics. 36, 2, p. 71-80 10 p.

Research output: Contribution to journalReview articleAcademicpeer-review

APA

Niehrs, C., & Calkhoven, C. F. (2020). Emerging Role of C/EBP beta and Epigenetic DNA Methylation in Ageing. Trends in Genetics, 36(2), 71-80. https://doi.org/10.1016/j.tig.2019.11.005

Author

Niehrs, Christof ; Calkhoven, Cornelis F. / Emerging Role of C/EBP beta and Epigenetic DNA Methylation in Ageing. In: Trends in Genetics. 2020 ; Vol. 36, No. 2. pp. 71-80.

Harvard

Niehrs, C & Calkhoven, CF 2020, 'Emerging Role of C/EBP beta and Epigenetic DNA Methylation in Ageing', Trends in Genetics, vol. 36, no. 2, pp. 71-80. https://doi.org/10.1016/j.tig.2019.11.005

Standard

Emerging Role of C/EBP beta and Epigenetic DNA Methylation in Ageing. / Niehrs, Christof; Calkhoven, Cornelis F.

In: Trends in Genetics, Vol. 36, No. 2, 02.2020, p. 71-80.

Research output: Contribution to journalReview articleAcademicpeer-review

Vancouver

Niehrs C, Calkhoven CF. Emerging Role of C/EBP beta and Epigenetic DNA Methylation in Ageing. Trends in Genetics. 2020 Feb;36(2):71-80. https://doi.org/10.1016/j.tig.2019.11.005


BibTeX

@article{8f23dca3bf5b4e6a8db1f9eb4ebb2db8,
title = "Emerging Role of C/EBP beta and Epigenetic DNA Methylation in Ageing",
abstract = "Changes in epigenetic DNA methylation are the most promising predictor of biological age and lifespan in humans, but whether methylation changes affect ageing is unresolved. Here, WE discuss converging data, which indicate that one mode by which aberrant DNA methylatior can affect ageing is via CCAAT/enhancer binding protein beta (C/ERP beta). This basic leucine-zippei (bZIP) transcription factor is controlled by the lifespan regulator mechanistic/mammalian target of rapamycin complex 1 (mTORC1) and plays an important role in energy homeostasis and adi pose tissue differentiation. Emerging evidence indicates that access of C/EBP beta proteins tc cognate binding sites is regulated by DNA demethylation via ten-eleven translocation (TET methylcytosine dioxygenases and their adaptor proteins growth arrest and DNA damage-induc ible protein 45 alpha (GADD45 alpha) and inhibitor of growth 1 (ING1). We discuss the emergins causal nexus between C/EBP beta, energy metabolism, and DNA demethylation in organisma ageing.",
keywords = "BINDING-PROTEIN-BETA, MESSENGER-RNA, ALPHA, AGE, GENE, CELLS, TRANSLATION, TISSUE, GADD45A, ARREST",
author = "Christof Niehrs and Calkhoven, {Cornelis F.}",
note = "Copyright {\circledC} 2019 Elsevier Ltd. All rights reserved.",
year = "2020",
month = "2",
doi = "10.1016/j.tig.2019.11.005",
language = "English",
volume = "36",
pages = "71--80",
journal = "Trends in Genetics",
issn = "0168-9525",
publisher = "ELSEVIER SCIENCE LONDON",
number = "2",

}

RIS

TY - JOUR

T1 - Emerging Role of C/EBP beta and Epigenetic DNA Methylation in Ageing

AU - Niehrs, Christof

AU - Calkhoven, Cornelis F.

N1 - Copyright © 2019 Elsevier Ltd. All rights reserved.

PY - 2020/2

Y1 - 2020/2

N2 - Changes in epigenetic DNA methylation are the most promising predictor of biological age and lifespan in humans, but whether methylation changes affect ageing is unresolved. Here, WE discuss converging data, which indicate that one mode by which aberrant DNA methylatior can affect ageing is via CCAAT/enhancer binding protein beta (C/ERP beta). This basic leucine-zippei (bZIP) transcription factor is controlled by the lifespan regulator mechanistic/mammalian target of rapamycin complex 1 (mTORC1) and plays an important role in energy homeostasis and adi pose tissue differentiation. Emerging evidence indicates that access of C/EBP beta proteins tc cognate binding sites is regulated by DNA demethylation via ten-eleven translocation (TET methylcytosine dioxygenases and their adaptor proteins growth arrest and DNA damage-induc ible protein 45 alpha (GADD45 alpha) and inhibitor of growth 1 (ING1). We discuss the emergins causal nexus between C/EBP beta, energy metabolism, and DNA demethylation in organisma ageing.

AB - Changes in epigenetic DNA methylation are the most promising predictor of biological age and lifespan in humans, but whether methylation changes affect ageing is unresolved. Here, WE discuss converging data, which indicate that one mode by which aberrant DNA methylatior can affect ageing is via CCAAT/enhancer binding protein beta (C/ERP beta). This basic leucine-zippei (bZIP) transcription factor is controlled by the lifespan regulator mechanistic/mammalian target of rapamycin complex 1 (mTORC1) and plays an important role in energy homeostasis and adi pose tissue differentiation. Emerging evidence indicates that access of C/EBP beta proteins tc cognate binding sites is regulated by DNA demethylation via ten-eleven translocation (TET methylcytosine dioxygenases and their adaptor proteins growth arrest and DNA damage-induc ible protein 45 alpha (GADD45 alpha) and inhibitor of growth 1 (ING1). We discuss the emergins causal nexus between C/EBP beta, energy metabolism, and DNA demethylation in organisma ageing.

KW - BINDING-PROTEIN-BETA

KW - MESSENGER-RNA

KW - ALPHA

KW - AGE

KW - GENE

KW - CELLS

KW - TRANSLATION

KW - TISSUE

KW - GADD45A

KW - ARREST

U2 - 10.1016/j.tig.2019.11.005

DO - 10.1016/j.tig.2019.11.005

M3 - Review article

VL - 36

SP - 71

EP - 80

JO - Trends in Genetics

JF - Trends in Genetics

SN - 0168-9525

IS - 2

ER -

ID: 109556537