Emerging Role of C/EBP beta and Epigenetic DNA Methylation in AgeingNiehrs, C. & Calkhoven, C. F., Feb-2020, In : Trends in Genetics. 36, 2, p. 71-80 10 p.
Research output: Contribution to journal › Review article › Academic › peer-review
Changes in epigenetic DNA methylation are the most promising predictor of biological age and lifespan in humans, but whether methylation changes affect ageing is unresolved. Here, WE discuss converging data, which indicate that one mode by which aberrant DNA methylatior can affect ageing is via CCAAT/enhancer binding protein beta (C/ERP beta). This basic leucine-zippei (bZIP) transcription factor is controlled by the lifespan regulator mechanistic/mammalian target of rapamycin complex 1 (mTORC1) and plays an important role in energy homeostasis and adi pose tissue differentiation. Emerging evidence indicates that access of C/EBP beta proteins tc cognate binding sites is regulated by DNA demethylation via ten-eleven translocation (TET methylcytosine dioxygenases and their adaptor proteins growth arrest and DNA damage-induc ible protein 45 alpha (GADD45 alpha) and inhibitor of growth 1 (ING1). We discuss the emergins causal nexus between C/EBP beta, energy metabolism, and DNA demethylation in organisma ageing.
|Number of pages||10|
|Journal||Trends in Genetics|
|Early online date||7-Dec-2019|
|Publication status||Published - Feb-2020|
- BINDING-PROTEIN-BETA, MESSENGER-RNA, ALPHA, AGE, GENE, CELLS, TRANSLATION, TISSUE, GADD45A, ARREST