Publication

Emergency Bleeding Control Interventions After Immediate Total-Body CT Scans in Trauma Patients

REACT-2 Study Grp, Treskes, K., Saltzherr, T. P., Edwards, M. J. R., Beuker, B. J. A., Den Hartog, D., Hohmann, J., Luitse, J. S., Beenen, L. F. M., Hollmann, M. W., Dijkgraaf, M. G. W. & Goslings, J. C., Feb-2019, In : World Journal of Surgery. 43, 2, p. 490-496 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

REACT-2 Study Grp, Treskes, K., Saltzherr, T. P., Edwards, M. J. R., Beuker, B. J. A., Den Hartog, D., ... Goslings, J. C. (2019). Emergency Bleeding Control Interventions After Immediate Total-Body CT Scans in Trauma Patients. World Journal of Surgery, 43(2), 490-496. https://doi.org/10.1007/s00268-018-4818-0

Author

REACT-2 Study Grp ; Treskes, Kaij ; Saltzherr, Teun P. ; Edwards, Michael J. R. ; Beuker, Benn J. A. ; Den Hartog, D. ; Hohmann, Joachim ; Luitse, Jan S. ; Beenen, Ludo F. M. ; Hollmann, Markus W. ; Dijkgraaf, Marcel G. W. ; Goslings, J. Carel. / Emergency Bleeding Control Interventions After Immediate Total-Body CT Scans in Trauma Patients. In: World Journal of Surgery. 2019 ; Vol. 43, No. 2. pp. 490-496.

Harvard

REACT-2 Study Grp, Treskes, K, Saltzherr, TP, Edwards, MJR, Beuker, BJA, Den Hartog, D, Hohmann, J, Luitse, JS, Beenen, LFM, Hollmann, MW, Dijkgraaf, MGW & Goslings, JC 2019, 'Emergency Bleeding Control Interventions After Immediate Total-Body CT Scans in Trauma Patients', World Journal of Surgery, vol. 43, no. 2, pp. 490-496. https://doi.org/10.1007/s00268-018-4818-0

Standard

Emergency Bleeding Control Interventions After Immediate Total-Body CT Scans in Trauma Patients. / REACT-2 Study Grp; Treskes, Kaij; Saltzherr, Teun P.; Edwards, Michael J. R.; Beuker, Benn J. A.; Den Hartog, D.; Hohmann, Joachim; Luitse, Jan S.; Beenen, Ludo F. M.; Hollmann, Markus W.; Dijkgraaf, Marcel G. W.; Goslings, J. Carel.

In: World Journal of Surgery, Vol. 43, No. 2, 02.2019, p. 490-496.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

REACT-2 Study Grp, Treskes K, Saltzherr TP, Edwards MJR, Beuker BJA, Den Hartog D et al. Emergency Bleeding Control Interventions After Immediate Total-Body CT Scans in Trauma Patients. World Journal of Surgery. 2019 Feb;43(2):490-496. https://doi.org/10.1007/s00268-018-4818-0


BibTeX

@article{db293b57d47045089f0cc0ffafc7daea,
title = "Emergency Bleeding Control Interventions After Immediate Total-Body CT Scans in Trauma Patients",
abstract = "BackgroundImmediate total-body CT (iTBCT) is often used for screening of potential severely injured patients. Patients requiring emergency bleeding control interventions benefit from fast and optimal trauma screening. The aim of this study was to assess whether an initial trauma assessment with iTBCT is associated with lower mortality in patients requiring emergency bleeding control interventions.MethodsIn the REACT-2 trial, patients who sustained major trauma were randomized for iTBCT or for conventional imaging and selective CT scanning (standard workup; STWU) in five trauma centers. Patients who underwent emergency bleeding control interventions following their initial trauma assessment with iTBCT were compared for mortality and clinically relevant time intervals to patients that underwent the initial trauma assessment with the STWU.ResultsIn the REACT-2 trial, 1083 patients were enrolled of which 172 (15.9{\%}) underwent emergency bleeding control interventions following their initial trauma assessment. Within these 172 patients, 85 (49.4{\%}) underwent iTBCT as primary diagnostic modality during the initial trauma assessment. In trauma patients requiring emergency bleeding control interventions, in-hospital mortality was 12.9{\%} (95{\%} CI 7.2-21.9{\%}) in the iTBCT group compared to 24.1{\%} (95{\%} CI 16.3-34.2{\%}) in the STWU group (p=0.059). Time to bleeding control intervention was not reduced; 82min (IQR 5-121) versus 98min (IQR 62-147), p=0.108.ConclusionsReduction in mortality in trauma patients requiring emergency bleeding control interventions by iTBCT could not be demonstrated in this study. However, a potentially clinically relevant absolute risk reduction of 11.2{\%} (95{\%} CI -0.3 to 22.7{\%}) in comparison with STWU was observed.Trial registrationClinicalTrials.gov: NCT01523626.",
keywords = "COMPUTED-TOMOGRAPHY, BLUNT",
author = "{REACT-2 Study Grp} and Kaij Treskes and Saltzherr, {Teun P.} and Edwards, {Michael J. R.} and Beuker, {Benn J. A.} and {Den Hartog}, D. and Joachim Hohmann and Luitse, {Jan S.} and Beenen, {Ludo F. M.} and Hollmann, {Markus W.} and Dijkgraaf, {Marcel G. W.} and Goslings, {J. Carel}",
year = "2019",
month = "2",
doi = "10.1007/s00268-018-4818-0",
language = "English",
volume = "43",
pages = "490--496",
journal = "World Journal of Surgery",
issn = "0364-2313",
publisher = "SPRINGER",
number = "2",

}

RIS

TY - JOUR

T1 - Emergency Bleeding Control Interventions After Immediate Total-Body CT Scans in Trauma Patients

AU - REACT-2 Study Grp

AU - Treskes, Kaij

AU - Saltzherr, Teun P.

AU - Edwards, Michael J. R.

AU - Beuker, Benn J. A.

AU - Den Hartog, D.

AU - Hohmann, Joachim

AU - Luitse, Jan S.

AU - Beenen, Ludo F. M.

AU - Hollmann, Markus W.

AU - Dijkgraaf, Marcel G. W.

AU - Goslings, J. Carel

PY - 2019/2

Y1 - 2019/2

N2 - BackgroundImmediate total-body CT (iTBCT) is often used for screening of potential severely injured patients. Patients requiring emergency bleeding control interventions benefit from fast and optimal trauma screening. The aim of this study was to assess whether an initial trauma assessment with iTBCT is associated with lower mortality in patients requiring emergency bleeding control interventions.MethodsIn the REACT-2 trial, patients who sustained major trauma were randomized for iTBCT or for conventional imaging and selective CT scanning (standard workup; STWU) in five trauma centers. Patients who underwent emergency bleeding control interventions following their initial trauma assessment with iTBCT were compared for mortality and clinically relevant time intervals to patients that underwent the initial trauma assessment with the STWU.ResultsIn the REACT-2 trial, 1083 patients were enrolled of which 172 (15.9%) underwent emergency bleeding control interventions following their initial trauma assessment. Within these 172 patients, 85 (49.4%) underwent iTBCT as primary diagnostic modality during the initial trauma assessment. In trauma patients requiring emergency bleeding control interventions, in-hospital mortality was 12.9% (95% CI 7.2-21.9%) in the iTBCT group compared to 24.1% (95% CI 16.3-34.2%) in the STWU group (p=0.059). Time to bleeding control intervention was not reduced; 82min (IQR 5-121) versus 98min (IQR 62-147), p=0.108.ConclusionsReduction in mortality in trauma patients requiring emergency bleeding control interventions by iTBCT could not be demonstrated in this study. However, a potentially clinically relevant absolute risk reduction of 11.2% (95% CI -0.3 to 22.7%) in comparison with STWU was observed.Trial registrationClinicalTrials.gov: NCT01523626.

AB - BackgroundImmediate total-body CT (iTBCT) is often used for screening of potential severely injured patients. Patients requiring emergency bleeding control interventions benefit from fast and optimal trauma screening. The aim of this study was to assess whether an initial trauma assessment with iTBCT is associated with lower mortality in patients requiring emergency bleeding control interventions.MethodsIn the REACT-2 trial, patients who sustained major trauma were randomized for iTBCT or for conventional imaging and selective CT scanning (standard workup; STWU) in five trauma centers. Patients who underwent emergency bleeding control interventions following their initial trauma assessment with iTBCT were compared for mortality and clinically relevant time intervals to patients that underwent the initial trauma assessment with the STWU.ResultsIn the REACT-2 trial, 1083 patients were enrolled of which 172 (15.9%) underwent emergency bleeding control interventions following their initial trauma assessment. Within these 172 patients, 85 (49.4%) underwent iTBCT as primary diagnostic modality during the initial trauma assessment. In trauma patients requiring emergency bleeding control interventions, in-hospital mortality was 12.9% (95% CI 7.2-21.9%) in the iTBCT group compared to 24.1% (95% CI 16.3-34.2%) in the STWU group (p=0.059). Time to bleeding control intervention was not reduced; 82min (IQR 5-121) versus 98min (IQR 62-147), p=0.108.ConclusionsReduction in mortality in trauma patients requiring emergency bleeding control interventions by iTBCT could not be demonstrated in this study. However, a potentially clinically relevant absolute risk reduction of 11.2% (95% CI -0.3 to 22.7%) in comparison with STWU was observed.Trial registrationClinicalTrials.gov: NCT01523626.

KW - COMPUTED-TOMOGRAPHY

KW - BLUNT

U2 - 10.1007/s00268-018-4818-0

DO - 10.1007/s00268-018-4818-0

M3 - Article

VL - 43

SP - 490

EP - 496

JO - World Journal of Surgery

JF - World Journal of Surgery

SN - 0364-2313

IS - 2

ER -

ID: 91994675