Publication

Emergence of a New Self-Replicator from a Dynamic Combinatorial Library Requires a Specific Pre-Existing Replicator

Altay, Y., Tezcan, M. & Otto, S., Sep-2017, In : Journal of the American Chemical Society. 139, 39, p. 13612-13615 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Altay, Y., Tezcan, M., & Otto, S. (2017). Emergence of a New Self-Replicator from a Dynamic Combinatorial Library Requires a Specific Pre-Existing Replicator. Journal of the American Chemical Society, 139(39), 13612-13615. https://doi.org/10.1021/jacs.7b07346

Author

Altay, Yigit ; Tezcan, Meniz ; Otto, Sijbren. / Emergence of a New Self-Replicator from a Dynamic Combinatorial Library Requires a Specific Pre-Existing Replicator. In: Journal of the American Chemical Society. 2017 ; Vol. 139, No. 39. pp. 13612-13615.

Harvard

Altay, Y, Tezcan, M & Otto, S 2017, 'Emergence of a New Self-Replicator from a Dynamic Combinatorial Library Requires a Specific Pre-Existing Replicator', Journal of the American Chemical Society, vol. 139, no. 39, pp. 13612-13615. https://doi.org/10.1021/jacs.7b07346

Standard

Emergence of a New Self-Replicator from a Dynamic Combinatorial Library Requires a Specific Pre-Existing Replicator. / Altay, Yigit; Tezcan, Meniz; Otto, Sijbren.

In: Journal of the American Chemical Society, Vol. 139, No. 39, 09.2017, p. 13612-13615.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Altay Y, Tezcan M, Otto S. Emergence of a New Self-Replicator from a Dynamic Combinatorial Library Requires a Specific Pre-Existing Replicator. Journal of the American Chemical Society. 2017 Sep;139(39):13612-13615. https://doi.org/10.1021/jacs.7b07346


BibTeX

@article{0d608ae532084e6b851785954faa03dd,
title = "Emergence of a New Self-Replicator from a Dynamic Combinatorial Library Requires a Specific Pre-Existing Replicator",
abstract = "Our knowledge regarding the early steps in the formation of evolvable life and what constitutes the minimal molecular basis of life remains far from complete. The recent emergence of systems chemistry reinvigorated the investigation of systems of self-replicating molecules to address these questions. Most of these studies focus on single replicators and the effects of replicators on the emergence of other replicators remains under-investigated. Here we show the cross-catalyzed emergence of a novel self-replicator from a dynamic combinatorial library made from a threonine containing peptide building block, which, by itself, only forms trimers and tetramers that do not replicate. Upon seeding of this library with different replicators of different macrocycle size (hexamers and octamers), we observed the emergence of hexamer replicator consisting of six units of the threonine peptide only when it is seeded with an octamer replicator containing eight units of a serine building block. These results reveal for the first time how a new replicator can emerge in a process that relies critically on the assistance by another replicator through cross-catalysis and that replicator composition is history dependent.",
keywords = "Journal Article, NONENZYMATIC RNA REPLICATION, SYSTEMS CHEMISTRY, REACTION NETWORK, PEPTIDE, HISTORY, AUTOCATALYSIS, AMPLIFICATION",
author = "Yigit Altay and Meniz Tezcan and Sijbren Otto",
year = "2017",
month = "9",
doi = "10.1021/jacs.7b07346",
language = "English",
volume = "139",
pages = "13612--13615",
journal = "Journal of the American Chemical Society",
issn = "0002-7863",
publisher = "AMER CHEMICAL SOC",
number = "39",

}

RIS

TY - JOUR

T1 - Emergence of a New Self-Replicator from a Dynamic Combinatorial Library Requires a Specific Pre-Existing Replicator

AU - Altay, Yigit

AU - Tezcan, Meniz

AU - Otto, Sijbren

PY - 2017/9

Y1 - 2017/9

N2 - Our knowledge regarding the early steps in the formation of evolvable life and what constitutes the minimal molecular basis of life remains far from complete. The recent emergence of systems chemistry reinvigorated the investigation of systems of self-replicating molecules to address these questions. Most of these studies focus on single replicators and the effects of replicators on the emergence of other replicators remains under-investigated. Here we show the cross-catalyzed emergence of a novel self-replicator from a dynamic combinatorial library made from a threonine containing peptide building block, which, by itself, only forms trimers and tetramers that do not replicate. Upon seeding of this library with different replicators of different macrocycle size (hexamers and octamers), we observed the emergence of hexamer replicator consisting of six units of the threonine peptide only when it is seeded with an octamer replicator containing eight units of a serine building block. These results reveal for the first time how a new replicator can emerge in a process that relies critically on the assistance by another replicator through cross-catalysis and that replicator composition is history dependent.

AB - Our knowledge regarding the early steps in the formation of evolvable life and what constitutes the minimal molecular basis of life remains far from complete. The recent emergence of systems chemistry reinvigorated the investigation of systems of self-replicating molecules to address these questions. Most of these studies focus on single replicators and the effects of replicators on the emergence of other replicators remains under-investigated. Here we show the cross-catalyzed emergence of a novel self-replicator from a dynamic combinatorial library made from a threonine containing peptide building block, which, by itself, only forms trimers and tetramers that do not replicate. Upon seeding of this library with different replicators of different macrocycle size (hexamers and octamers), we observed the emergence of hexamer replicator consisting of six units of the threonine peptide only when it is seeded with an octamer replicator containing eight units of a serine building block. These results reveal for the first time how a new replicator can emerge in a process that relies critically on the assistance by another replicator through cross-catalysis and that replicator composition is history dependent.

KW - Journal Article

KW - NONENZYMATIC RNA REPLICATION

KW - SYSTEMS CHEMISTRY

KW - REACTION NETWORK

KW - PEPTIDE

KW - HISTORY

KW - AUTOCATALYSIS

KW - AMPLIFICATION

U2 - 10.1021/jacs.7b07346

DO - 10.1021/jacs.7b07346

M3 - Article

VL - 139

SP - 13612

EP - 13615

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

SN - 0002-7863

IS - 39

ER -

ID: 49203949