Publication

Eliciting dose is associated with tolerance development in peanut and cow's milk allergic children

Nitsche, C., Westerlaken-van Ginkel, C. D., Kollen, B. J., Sprikkelman, A. B., Koppelman, G. H. & Dubois, A. E. J., 6-Nov-2019, In : Clinical and translational allergy. 9, 1, 6 p., 58.

Research output: Contribution to journalLetterAcademicpeer-review

APA

Nitsche, C., Westerlaken-van Ginkel, C. D., Kollen, B. J., Sprikkelman, A. B., Koppelman, G. H., & Dubois, A. E. J. (2019). Eliciting dose is associated with tolerance development in peanut and cow's milk allergic children. Clinical and translational allergy, 9(1), [58]. https://doi.org/10.1186/s13601-019-0298-z

Author

Nitsche, C. ; Westerlaken-van Ginkel, C. D. ; Kollen, B. J. ; Sprikkelman, A. B. ; Koppelman, G. H. ; Dubois, A. E. J. / Eliciting dose is associated with tolerance development in peanut and cow's milk allergic children. In: Clinical and translational allergy. 2019 ; Vol. 9, No. 1.

Harvard

Nitsche, C, Westerlaken-van Ginkel, CD, Kollen, BJ, Sprikkelman, AB, Koppelman, GH & Dubois, AEJ 2019, 'Eliciting dose is associated with tolerance development in peanut and cow's milk allergic children', Clinical and translational allergy, vol. 9, no. 1, 58. https://doi.org/10.1186/s13601-019-0298-z

Standard

Eliciting dose is associated with tolerance development in peanut and cow's milk allergic children. / Nitsche, C.; Westerlaken-van Ginkel, C. D.; Kollen, B. J.; Sprikkelman, A. B.; Koppelman, G. H.; Dubois, A. E. J.

In: Clinical and translational allergy, Vol. 9, No. 1, 58, 06.11.2019.

Research output: Contribution to journalLetterAcademicpeer-review

Vancouver

Nitsche C, Westerlaken-van Ginkel CD, Kollen BJ, Sprikkelman AB, Koppelman GH, Dubois AEJ. Eliciting dose is associated with tolerance development in peanut and cow's milk allergic children. Clinical and translational allergy. 2019 Nov 6;9(1). 58. https://doi.org/10.1186/s13601-019-0298-z


BibTeX

@article{b939f0ffc01949119ef13544e8e415f4,
title = "Eliciting dose is associated with tolerance development in peanut and cow's milk allergic children",
abstract = "Background: Tolerance development rates differ between food allergies. Almost all previous studies have not used the gold standard method, the double-blind, placebo-controlled food challenge (DBPCFC), which may affect the reported prevalence rates. Little is known about the association of the eliciting dose (ED) obtained during the initial DBPCFC with later tolerance development.Methods: This was a retrospective, tertiary care study of children who had a positive DBPCFC to either peanut, milk or egg, and at least one follow-up food challenge (open or DBPCFC) with the same food. The association between ED and negative (tolerant) follow-up food challenge outcome was analyzed by logistic regression, with adjustment for confounders. Suspected confounders were initial DBPCFC test characteristics, atopic comorbidities and serum specific IgE (sIgE) levels.Results: In 47 peanut allergic children, tolerance developed in 27.7{\%} (median follow-up duration of 43 months). In 80 milk (follow-up 23 months) and 55 egg (follow-up 37 months) allergic children, tolerance developed in 55.0{\%} and 65.5{\%}. The ED obtained during the initial DBPCFC was significantly associated with tolerance development in peanut and milk allergy, but not in egg allergy.Conclusion: Approximately 1 out of 4 children with DBPCFC confirmed peanut allergy developed tolerance, compared to more than half of the children with milk or egg allergy, respectively. Tolerance development in peanut and milk allergy is significantly associated with ED at initial DBPCFC.",
keywords = "Food allergy, Pediatrics, Eliciting dose, Prognosis, Atopic dermatitis, CONTROLLED FOOD CHALLENGES, DOUBLE-BLIND, NATURAL-HISTORY",
author = "C. Nitsche and {Westerlaken-van Ginkel}, {C. D.} and Kollen, {B. J.} and Sprikkelman, {A. B.} and Koppelman, {G. H.} and Dubois, {A. E. J.}",
note = "{\circledC} The Author(s) 2019.",
year = "2019",
month = "11",
day = "6",
doi = "10.1186/s13601-019-0298-z",
language = "English",
volume = "9",
journal = "Clinical and translational allergy",
issn = "2045-7022",
publisher = "BMC",
number = "1",

}

RIS

TY - JOUR

T1 - Eliciting dose is associated with tolerance development in peanut and cow's milk allergic children

AU - Nitsche, C.

AU - Westerlaken-van Ginkel, C. D.

AU - Kollen, B. J.

AU - Sprikkelman, A. B.

AU - Koppelman, G. H.

AU - Dubois, A. E. J.

N1 - © The Author(s) 2019.

PY - 2019/11/6

Y1 - 2019/11/6

N2 - Background: Tolerance development rates differ between food allergies. Almost all previous studies have not used the gold standard method, the double-blind, placebo-controlled food challenge (DBPCFC), which may affect the reported prevalence rates. Little is known about the association of the eliciting dose (ED) obtained during the initial DBPCFC with later tolerance development.Methods: This was a retrospective, tertiary care study of children who had a positive DBPCFC to either peanut, milk or egg, and at least one follow-up food challenge (open or DBPCFC) with the same food. The association between ED and negative (tolerant) follow-up food challenge outcome was analyzed by logistic regression, with adjustment for confounders. Suspected confounders were initial DBPCFC test characteristics, atopic comorbidities and serum specific IgE (sIgE) levels.Results: In 47 peanut allergic children, tolerance developed in 27.7% (median follow-up duration of 43 months). In 80 milk (follow-up 23 months) and 55 egg (follow-up 37 months) allergic children, tolerance developed in 55.0% and 65.5%. The ED obtained during the initial DBPCFC was significantly associated with tolerance development in peanut and milk allergy, but not in egg allergy.Conclusion: Approximately 1 out of 4 children with DBPCFC confirmed peanut allergy developed tolerance, compared to more than half of the children with milk or egg allergy, respectively. Tolerance development in peanut and milk allergy is significantly associated with ED at initial DBPCFC.

AB - Background: Tolerance development rates differ between food allergies. Almost all previous studies have not used the gold standard method, the double-blind, placebo-controlled food challenge (DBPCFC), which may affect the reported prevalence rates. Little is known about the association of the eliciting dose (ED) obtained during the initial DBPCFC with later tolerance development.Methods: This was a retrospective, tertiary care study of children who had a positive DBPCFC to either peanut, milk or egg, and at least one follow-up food challenge (open or DBPCFC) with the same food. The association between ED and negative (tolerant) follow-up food challenge outcome was analyzed by logistic regression, with adjustment for confounders. Suspected confounders were initial DBPCFC test characteristics, atopic comorbidities and serum specific IgE (sIgE) levels.Results: In 47 peanut allergic children, tolerance developed in 27.7% (median follow-up duration of 43 months). In 80 milk (follow-up 23 months) and 55 egg (follow-up 37 months) allergic children, tolerance developed in 55.0% and 65.5%. The ED obtained during the initial DBPCFC was significantly associated with tolerance development in peanut and milk allergy, but not in egg allergy.Conclusion: Approximately 1 out of 4 children with DBPCFC confirmed peanut allergy developed tolerance, compared to more than half of the children with milk or egg allergy, respectively. Tolerance development in peanut and milk allergy is significantly associated with ED at initial DBPCFC.

KW - Food allergy

KW - Pediatrics

KW - Eliciting dose

KW - Prognosis

KW - Atopic dermatitis

KW - CONTROLLED FOOD CHALLENGES

KW - DOUBLE-BLIND

KW - NATURAL-HISTORY

U2 - 10.1186/s13601-019-0298-z

DO - 10.1186/s13601-019-0298-z

M3 - Letter

VL - 9

JO - Clinical and translational allergy

JF - Clinical and translational allergy

SN - 2045-7022

IS - 1

M1 - 58

ER -

ID: 102376739