Publication
Elevator-type mechanisms of membrane transport
Garaeva, A. A. & Slotboom, D. J., Jun-2020, In : Biochemical Society Transactions. 48, 3, p. 1227-1241 15 p., BST20200290.Research output: Contribution to journal › Review article › Academic › peer-review

Documents
- Elevator-type mechanisms of membrane transport
Final publisher's version, 7.07 MB, PDF document
DOI
Membrane transporters are integral membrane proteins that mediate the passage of solutes across lipid bilayers. These proteins undergo conformational transitions between outward- and inward-facing states, which lead to alternating access of the substrate-binding site to the aqueous environment on either side of the membrane. Dozens of different transporter families have evolved, providing a wide variety of structural solutions to achieve alternating access. A sub-set of structurally diverse transporters operate by mechanisms that are collectively named 'elevator-type'. These transporters have one common characteristic: they contain a distinct protein domain that slides across the membrane as a rigid body, and in doing so it 'drags" the transported substrate along. Analysis of the global conformational changes that take place in membrane transporters using elevator-type mechanisms reveals that elevator-type movements can be achieved in more than one way. Molecular dynamics simulations and experimental data help to understand how lipid bilayer properties may affect elevator movements and vice versa.
Original language | English |
---|---|
Article number | BST20200290 |
Pages (from-to) | 1227-1241 |
Number of pages | 15 |
Journal | Biochemical Society Transactions |
Volume | 48 |
Issue number | 3 |
Early online date | 2020 |
Publication status | Published - Jun-2020 |
- membrane proteins, protein structure, transport, AMINO-ACID TRANSPORTERS, SUBSTRATE-BINDING SITE, CRYSTAL-STRUCTURE, STRUCTURAL BIOLOGY, BACTERIAL HOMOLOG, S-COMPONENT, GLUTAMATE, TRANSLOCATION, INSIGHTS, ANTIPORTER
Keywords
Download statistics
ID: 124809216