Elevated circulating stromal-derived factor-1 levels in sickle cell disease

Landburg, P. P., Nur, E., Maria, N., Brandjes, D. P. M., Biemond, B. J., Schnog, J. B., Duits, A. J. & CURAMA study group, 2009, In : ACTA HAEMATOLOGICA. 122, 1, p. 64-9 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • P P Landburg
  • E Nur
  • N Maria
  • D P M Brandjes
  • B J Biemond
  • J B Schnog
  • A J Duits
  • CURAMA study group

Inflammation and angiogenesis are of importance in the pathophysiology of sickle cell disease (SCD). Recently, the chemokine stromal-derived factor-1 (SDF-1) has been shown to be a key mediator of angiogenesis and inflammation. In this study we determined serum SDF-1 levels in consecutive adult sickle cell patients during the clinically asymptomatic state as well as during painful crisis. Serum SDF-1 levels were significantly elevated in HbSS/HbSbeta(0)-thalassaemia patients [n = 42; 5,177 pg/ml (2,438-7,246)] compared to HbSC/HbSbeta(+)-thalassaemia patients [n = 16; 2,405 pg/ml (1,365-3,047)] and healthy HbAA controls [n = 45; 2,894 pg/ml (2,577-3,334)] (p = 0.001). No significant increments were observed during painful crisis (n = 40). SDF-1 levels were significantly higher in SCD patients with pulmonary hypertension (PHT) compared to patients without PHT. Elevated circulating SDF-1 levels occur in patients with SCD and may play a role in the pathophysiology of SCD-related PHT.

Original languageEnglish
Pages (from-to)64-9
Number of pages6
Issue number1
Publication statusPublished - 2009


  • Adult, Anemia, Sickle Cell, Chemokine CXCL12, Female, Humans, Hypertension, Pulmonary, Male, Middle Aged, Pain

ID: 31176864