Electrosynthesis methods and approaches for the preparative production of metabolites from parent drugsGül, T., Bischoff, R. & Permentier, H. 1-Jul-2015 In : TrAC-Trends in Analytical Chemistry. 70, p. 58-66
Research output: Scientific - peer-review › Article
Identification of potentially toxic metabolites is important for drug discovery and development. Synthesis of drug metabolites is typically performed by organic synthesis or enzymatic methods, but is not always straightforward. Electrochemical (EC) methods are increasingly used to study drug oxidation and to identify potential metabolites of new drug candidates, but the absolute yield of metabolites of these methods is low. This review discusses the challenges and recent developments of EC synthesis in terms of instrumental aspects, EC-reaction parameters and reaction-monitoring approaches, in an effort to produce drug metabolites selectively from parent drugs on a preparative scale (1–10 mg).
|Journal||TrAC-Trends in Analytical Chemistry|
|State||Published - 1-Jul-2015|
- Batch cell Cytochrome P450 Drug metabolism Drug oxidation Electrochemistry Electrode material Electrosynthesis Flow-through cell Metabolite Preparative synthesis