Electrochemical oxidation by square-wave potential pulses in the imitation of phenacetin to acetaminophen biotransformation

Nouri-Nigjeh, E., Bischoff, R., Bruins, A. P. & Permentier, H. P., 2011, In : Analyst. 136, 23, p. 5064-5067 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Electrochemistry in combination with mass spectrometry is emerging as a versatile analytical technique in the imitation of oxidative drug metabolism during the early stages of drug discovery and development. Here, we present electrochemical O-dealkylation of phenacetin to acetaminophen by square-wave potential pulses consisting of consecutive sub-second oxidation and reduction steps. This O-dealkylation could not be achieved by oxidation at constant potential or longer potential pulses because of the fast hydrolysis of the reactive intermediates. Electrochemical conversion by square-wave potential pulses can thus widen the scope of electrochemical synthesis of metabolites and imitation of in vivo drug metabolism.

Original languageEnglish
Pages (from-to)5064-5067
Number of pages4
Issue number23
Publication statusPublished - 2011



ID: 5435388