Publication

EGFR gene copy number increase in vulvar carcinomas is linked with poor clinical outcome

Woelber, L., Hess, S., Bohlken, H., Tennstedt, P., Eulenburg, C., Simon, R., Gieseking, F., Jaenicke, F., Mahner, S. & Choschzick, M., Feb-2012, In : Journal of Clinical Pathology. 65, 2, p. 133-139 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • L. Woelber
  • S. Hess
  • H. Bohlken
  • P. Tennstedt
  • C. Eulenburg
  • R. Simon
  • F. Gieseking
  • F. Jaenicke
  • S. Mahner
  • M. Choschzick

EGFR copy number increases have been frequently reported in cancer including vulvar carcinomas. Co-amplification of cancer genes plays an important role in the development of many tumour types. To better understand the effect of EGFR aberrations on vulvar cancer phenotype and patient prognosis, the authors analysed EGFR copy number changes using fluorescence in situ hybridisation and EGFR expression by immunohistochemistry in a tissue microarray containing 183 squamous cell carcinomas of vulva. Furthermore, the authors analysed the co-amplification frequency of EGFR with HER2, CCND1, MYC and PIK3CA, respectively. EGFR copy number increase was found in 39.3% of the tumours. Seventeen per cent of vulvar carcinomas showed EGFR high polysomy including 9% with amplification of the EGFR gene. Copy number gain of the EGFR locus was associated with non-basaloid phenotype (p=0.03), high-tumour stage (p

Original languageEnglish
Pages (from-to)133-139
Number of pages7
JournalJournal of Clinical Pathology
Volume65
Issue number2
Publication statusPublished - Feb-2012
Externally publishedYes

    Keywords

  • GROWTH-FACTOR-RECEPTOR, SQUAMOUS-CELL CARCINOMA, HUMAN-PAPILLOMAVIRUS DNA, IN-SITU HYBRIDIZATION, LUNG CARCINOMAS, ERBB RECEPTORS, BREAST-CANCER, CYCLIN D1, PROGNOSTIC-SIGNIFICANCE, PROTEIN OVEREXPRESSION

ID: 34212070