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Efficient global sensitivity analysis of biochemical networks using Gaussian process regression

Kurdyaeva, T. & Milias-Argeitis, A., 18-Jan-2019, 2018 IEEE Conference on Decision and Control, CDC 2018. Institute of Electrical and Electronics Engineers Inc., p. 2673-2678 6 p. 8618902. (Proceedings of the IEEE Conference on Decision and Control).

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  • Efficient global sensitivity analysis of biochemical networks using Gaussian process regression

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DOI

A key objective of systems biology is to understand how the uncertainty in parameter values affects the responses of biochemical networks. Variance-based sensitivity analysis is a powerful approach to address this question. However, commonly used implementations based on (Quasi-) Monte Carlo require a very large number of model evaluations, and are thus impractical for computationally expensive models. Here, we present an alternative method for variance-based sensitivity analysis that uses Gaussian process regression. Thanks to the appealing mathematical properties of Gaussian processes, we are able to derive exact analytic formulas for the required sensitivity indices. In this way our approach yields more accurate estimates with significantly less computational cost compared to conventional methods, as we demonstrate for a nonlinear model of a bacterial signaling system.

Original languageEnglish
Title of host publication2018 IEEE Conference on Decision and Control, CDC 2018
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages2673-2678
Number of pages6
ISBN (Electronic)978-1-5386-1395-5
ISBN (Print)978-1-5386-1396-2
Publication statusPublished - 18-Jan-2019
Event57th IEEE Conference on Decision and Control, CDC 2018 - Miami, United States
Duration: 17-Dec-201819-Dec-2018

Publication series

NameProceedings of the IEEE Conference on Decision and Control
ISSN (Print)0743-1546
ISSN (Electronic)2576-2370

Conference

Conference57th IEEE Conference on Decision and Control, CDC 2018
CountryUnited States
CityMiami
Period17/12/201819/12/2018

Event

57th IEEE Conference on Decision and Control, CDC 2018

17/12/201819/12/2018

Miami, United States

Event: Conference

ID: 95844781