Publication

Efficacy of typical and atypical antipsychotic medication on hostility in patients with psychosis-spectrum disorders: a review and meta-analysis

Faay, M. D. M., Czobor, P. & Sommer, I. E. C., Nov-2018, In : Neuropsychopharmacology. 43, 12, p. 2340-2349 10 p.

Research output: Contribution to journalReview articleAcademicpeer-review

APA

Faay, M. D. M., Czobor, P., & Sommer, I. E. C. (2018). Efficacy of typical and atypical antipsychotic medication on hostility in patients with psychosis-spectrum disorders: a review and meta-analysis. Neuropsychopharmacology, 43(12), 2340-2349. https://doi.org/10.1038/s41386-018-0161-2

Author

Faay, Margo D. M. ; Czobor, Pal ; Sommer, Iris E. C. / Efficacy of typical and atypical antipsychotic medication on hostility in patients with psychosis-spectrum disorders : a review and meta-analysis. In: Neuropsychopharmacology. 2018 ; Vol. 43, No. 12. pp. 2340-2349.

Harvard

Faay, MDM, Czobor, P & Sommer, IEC 2018, 'Efficacy of typical and atypical antipsychotic medication on hostility in patients with psychosis-spectrum disorders: a review and meta-analysis', Neuropsychopharmacology, vol. 43, no. 12, pp. 2340-2349. https://doi.org/10.1038/s41386-018-0161-2

Standard

Efficacy of typical and atypical antipsychotic medication on hostility in patients with psychosis-spectrum disorders : a review and meta-analysis. / Faay, Margo D. M.; Czobor, Pal; Sommer, Iris E. C.

In: Neuropsychopharmacology, Vol. 43, No. 12, 11.2018, p. 2340-2349.

Research output: Contribution to journalReview articleAcademicpeer-review

Vancouver

Faay MDM, Czobor P, Sommer IEC. Efficacy of typical and atypical antipsychotic medication on hostility in patients with psychosis-spectrum disorders: a review and meta-analysis. Neuropsychopharmacology. 2018 Nov;43(12):2340-2349. https://doi.org/10.1038/s41386-018-0161-2


BibTeX

@article{b9548c1a291648d8bfda11e801781a4a,
title = "Efficacy of typical and atypical antipsychotic medication on hostility in patients with psychosis-spectrum disorders: a review and meta-analysis",
abstract = "As violence against self and others is an important outcome in the treatment of patients with psychosis-spectrum disorders and hostility is an important indicator for violence, we set out to evaluate the effects of different types of antipsychotic agents in reducing hostility. We performed a systematic literature search, which provided 18 suitable randomized studies comparing typical to atypical antipsychotics for at least 4 weeks in patients with psychotic disorders. Results showed a small (0.26) but significant effect for atypical as compared to typical antipsychotics, with high heterogeneity, even though the mean dose of typical antipsychotics was higher. This effect size remained similar when separately analyzing sponsored and non-sponsored studies. When differentiating between high and low-dose studies, the high-dose group showed a significant difference between typical and atypical antipsychotics whereas the low-dose group did not. An analysis comparing clozapine to typical antipsychotics showed a moderate effect size (0.415), with low heterogeneity. These results are important for clinicians to help their shared decision making with patients when choosing maintenance treatment, as next to efficacy for psychosis and tolerability, safety for the patient and their environment is an important outcome.",
keywords = "SCHIZOPHRENIC-PATIENTS, DOUBLE-BLIND, 1ST-EPISODE SCHIZOPHRENIA, 5 DIMENSIONS, CLOZAPINE, RISPERIDONE, AGGRESSION, HALOPERIDOL, OLANZAPINE, RESISTANT",
author = "Faay, {Margo D. M.} and Pal Czobor and Sommer, {Iris E. C.}",
year = "2018",
month = "11",
doi = "10.1038/s41386-018-0161-2",
language = "English",
volume = "43",
pages = "2340--2349",
journal = "Neuropsychopharmacology",
issn = "0893-133x",
publisher = "Nature Publishing Group",
number = "12",

}

RIS

TY - JOUR

T1 - Efficacy of typical and atypical antipsychotic medication on hostility in patients with psychosis-spectrum disorders

T2 - a review and meta-analysis

AU - Faay, Margo D. M.

AU - Czobor, Pal

AU - Sommer, Iris E. C.

PY - 2018/11

Y1 - 2018/11

N2 - As violence against self and others is an important outcome in the treatment of patients with psychosis-spectrum disorders and hostility is an important indicator for violence, we set out to evaluate the effects of different types of antipsychotic agents in reducing hostility. We performed a systematic literature search, which provided 18 suitable randomized studies comparing typical to atypical antipsychotics for at least 4 weeks in patients with psychotic disorders. Results showed a small (0.26) but significant effect for atypical as compared to typical antipsychotics, with high heterogeneity, even though the mean dose of typical antipsychotics was higher. This effect size remained similar when separately analyzing sponsored and non-sponsored studies. When differentiating between high and low-dose studies, the high-dose group showed a significant difference between typical and atypical antipsychotics whereas the low-dose group did not. An analysis comparing clozapine to typical antipsychotics showed a moderate effect size (0.415), with low heterogeneity. These results are important for clinicians to help their shared decision making with patients when choosing maintenance treatment, as next to efficacy for psychosis and tolerability, safety for the patient and their environment is an important outcome.

AB - As violence against self and others is an important outcome in the treatment of patients with psychosis-spectrum disorders and hostility is an important indicator for violence, we set out to evaluate the effects of different types of antipsychotic agents in reducing hostility. We performed a systematic literature search, which provided 18 suitable randomized studies comparing typical to atypical antipsychotics for at least 4 weeks in patients with psychotic disorders. Results showed a small (0.26) but significant effect for atypical as compared to typical antipsychotics, with high heterogeneity, even though the mean dose of typical antipsychotics was higher. This effect size remained similar when separately analyzing sponsored and non-sponsored studies. When differentiating between high and low-dose studies, the high-dose group showed a significant difference between typical and atypical antipsychotics whereas the low-dose group did not. An analysis comparing clozapine to typical antipsychotics showed a moderate effect size (0.415), with low heterogeneity. These results are important for clinicians to help their shared decision making with patients when choosing maintenance treatment, as next to efficacy for psychosis and tolerability, safety for the patient and their environment is an important outcome.

KW - SCHIZOPHRENIC-PATIENTS

KW - DOUBLE-BLIND

KW - 1ST-EPISODE SCHIZOPHRENIA

KW - 5 DIMENSIONS

KW - CLOZAPINE

KW - RISPERIDONE

KW - AGGRESSION

KW - HALOPERIDOL

KW - OLANZAPINE

KW - RESISTANT

U2 - 10.1038/s41386-018-0161-2

DO - 10.1038/s41386-018-0161-2

M3 - Review article

VL - 43

SP - 2340

EP - 2349

JO - Neuropsychopharmacology

JF - Neuropsychopharmacology

SN - 0893-133x

IS - 12

ER -

ID: 66525111