Effects of testosterone administration on selective aspects of object-location memory in healthy young women

Postma, A., Tuiten, A., van Honk, J., Kessels, RPC. & Thijssen, J., Aug-2000, In : Psychoneuroendocrinology. 25, 6, p. 563-575 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • A Postma
  • A Tuiten
  • J van Honk
  • RPC Kessels
  • J Thijssen

Previous work has indicated that object-location memory is sensitive to sex differences as well as variations in the menstrual cycle. The goal of the present study was to further examine the hormonal basis of human spatial memory by assessing the effects of a single dose of exogenous testosterone in healthy young women on three recall conditions: positional reconstruction; object-to-position-assignment; and the combined condition in which subjects both have to reconstruct the precise locations and to link the different objects to the correct places. In the latter condition, delayed recall (3 min delay) improved with testosterone. Although the effects were only small and need further substantiation, they support the idea that testosterone may have an activational effect on selective aspects of cognitive functioning. (C) 2000 Elsevier Science Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)563-575
Number of pages13
Issue number6
Publication statusPublished - Aug-2000


  • spatial cognition, object-location memory, testosterone administration, sex characteristics, hormonal mechanisms, placebo-controlled, SPATIAL WORKING-MEMORY, FRONTAL-LOBE EXCISIONS, SEX-DIFFERENCES, MENSTRUAL-CYCLE, HAND PREFERENCE, ESTROUS-CYCLE, MEN, HORMONES, HUMANS, COGNITION

ID: 3880180