Publication

Effects of n-3 PUFA enriched and n-3 PUFA deficient diets in naive and Aβ-treated female rats

Bove, M., Mhillaj, E., Tucci, P., Giardino, I., Schiavone, S., Morgese, M. G. & Trabace, L., Sep-2018, In : Biochemical Pharmacology. 155, p. 326-335 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Copy link to clipboard

Documents

  • Effects of n-3 PUFA enriched and n-3 PUFA deficient diets in naïve

    Final publisher's version, 946 KB, PDF document

    Request copy

DOI

  • Maria Bove
  • Emanuela Mhillaj
  • Paolo Tucci
  • Ida Giardino
  • Stefania Schiavone
  • Maria Grazia Morgese
  • Luigia Trabace

Depression is one of the most common psychiatric diseases and the prevalence of depressive symptoms in women is almost twice compared to men, although the reasons of this gender difference are not fully understood yet. Recently, soluble A beta(1-42) peptide has been receiving great importance in the development of depression, also since depression is highly comorbid with Alzheimer's disease and other neurodegenerative illnesses. Accordingly, we have previously shown that central A beta injection is able to elicit depressive-like phenotype in male rats. In the present study, we reproduced for the first time the A beta-induced depressive-like model in female rats, evaluating behavioural and neurochemical outcomes. Moreover, we studied the effect of lifelong exposure to either n-3 PUFA enriched or n-3 PUFA deficient diet, in female rats, both intact and after central A beta administration. Our results confirmed the A beta-induced depressive-like profile also in female rats. Moreover, chronic exposure to n-3 PUFA deficient diet led to highly negative alterations in behavioural and neurochemical parameters, while lifelong exposure to n-3 PUFA enriched diet was able to restore the A beta-induced depressive-like profile in female rats. In conclusion, the A beta-induced depressive-like profile was reversed by n-3 PUFA supplementation, indicating a possible therapeutic role of n-3 PUFA in the treatment of the burden of depressive disorders.

Original languageEnglish
Pages (from-to)326-335
Number of pages10
JournalBiochemical Pharmacology
Volume155
Publication statusPublished - Sep-2018

    Keywords

  • PUFA, Soluble amyloid beta, Depressive-like profile, Female rats, DEPRESSIVE-LIKE BEHAVIOR, FATTY-ACID, DOCOSAHEXAENOIC ACID, GENDER-DIFFERENCES, SEX-DIFFERENCES, ALZHEIMERS-DISEASE, PREFRONTAL CORTEX, DOPAMINE, BRAIN, SEROTONIN

View graph of relations

ID: 78713308