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Effects of inorganic cations on K+-, 5-hydroxytryptamine- and noradrenaline-induced contractions of the isolated rat jugular vein and aorta

Gouw, M. A. M., Wilffert, B. & Van Zwieten, P. A., 22-Oct-1990, In : European Journal of Pharmacology. 185, 2-3, p. 147-155 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

We investigated the inhibitory effects of 1 mM of the inorganic cations, La3+, Cd2+, Mn2+, Ni2+and Co2+on contractions induced by K+(100 mM) and 5-hydroxytryptamine (5-HT, 10-5M) in the isolated rat jugular vein and on contractions induced by K+(100 mM), 5-HT (10-5) and noradrenaline (NA, 10-5M) in the rat aorta. In the venous preparation, both K+- and 5-HT-induced CA2+influx could be suppressed completely by all cations studied. In the aorta, the K+-induced Ca2+influx was antagonized completely only by Cd2+. The other cations were less effective and Mn2+was completely ineffective. Similarly to that in the venous preparation, the 5-HT-induced Ca2+influx in the aorta was abolished by all the cations. A similar picture was found for the NA-induced Ca2+influx with the exception of Mn2+, which antagonized the NA-induced contractions only slightly. Although organic calcium entry blockers (CEBs) (nifedipine, diltiazem, flunarizine and gallopamil) inhibited NA-induced contractions to the same extent as did Mn2+, a combination of organic CEBs and Mn2+abolished the NA-induced Ca2+influx completely. Apparently, organic CEBs and Mn2+block components of the NA-induced Ca2+influx pathway.
Original languageEnglish
Pages (from-to)147-155
Number of pages9
JournalEuropean Journal of Pharmacology
Volume185
Issue number2-3
Publication statusPublished - 22-Oct-1990

    Keywords

  • agonist-induced contractions, arterial tissue, cations, K+-induced contractions, potential-operated channels (POC), receptor-operated channels (ROC), venous tissue, cadmium, cation, cobalt, diltiazem, flunarizine, gallopamil, lanthanum, manganese, nickel, nifedipine, noradrenalin, potassium ion, serotonin, animal cell, aorta, article, calcium transport, jugular vein, male, nonhuman, priority journal, rat, smooth muscle contractility

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