Publication

Effects of atomoxetine on attention in Wistar rats treated with the neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4)

Hauser, J., Reissmann, A., Sontag, T. A., Tucha, O. & Lange, K. W., Dec-2017, In : ADHD Attention Deficit and Hyperactivity Disorders. 9, 4, p. 253-262 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Hauser, J., Reissmann, A., Sontag, T. A., Tucha, O., & Lange, K. W. (2017). Effects of atomoxetine on attention in Wistar rats treated with the neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4). ADHD Attention Deficit and Hyperactivity Disorders, 9(4), 253-262. https://doi.org/10.1007/s12402-017-0225-x

Author

Hauser, J. ; Reissmann, A. ; Sontag, T.A. ; Tucha, Oliver ; Lange, K.W. / Effects of atomoxetine on attention in Wistar rats treated with the neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4). In: ADHD Attention Deficit and Hyperactivity Disorders. 2017 ; Vol. 9, No. 4. pp. 253-262.

Harvard

Hauser, J, Reissmann, A, Sontag, TA, Tucha, O & Lange, KW 2017, 'Effects of atomoxetine on attention in Wistar rats treated with the neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4)' ADHD Attention Deficit and Hyperactivity Disorders, vol. 9, no. 4, pp. 253-262. https://doi.org/10.1007/s12402-017-0225-x

Standard

Effects of atomoxetine on attention in Wistar rats treated with the neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4). / Hauser, J.; Reissmann, A.; Sontag, T.A.; Tucha, Oliver; Lange, K.W.

In: ADHD Attention Deficit and Hyperactivity Disorders, Vol. 9, No. 4, 12.2017, p. 253-262.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Hauser J, Reissmann A, Sontag TA, Tucha O, Lange KW. Effects of atomoxetine on attention in Wistar rats treated with the neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4). ADHD Attention Deficit and Hyperactivity Disorders. 2017 Dec;9(4):253-262. https://doi.org/10.1007/s12402-017-0225-x


BibTeX

@article{9b248e6c393a4b6daa9dbd03d4766a9d,
title = "Effects of atomoxetine on attention in Wistar rats treated with the neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4)",
abstract = "The aim of the present study was to assess the effects of the neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4), which allows a depletion of noradrenergic terminals in a dose-dependent manner, on attention in rats as measured using the five-choice serial-reaction time task (5CSRTT). In addition, we investigated whether the effects of DSP4 treatment can be reversed by atomoxetine. Atomoxetine is a selective noradrenaline reuptake inhibitor and has been shown to be effective in the treatment of attention deficit hyperactivity disorder. Wistar rats were trained in the 5CSRTT and treated with one of the three doses of DSP4 (10, 20 or 50 mg/kg) or saline. Following DSP4 treatment, rats were injected with three doses of atomoxetine (0.1, 0.5 or 1 mg/kg) or saline and tested in the 5CSRTT. The treatment with DSP4 caused a reduction in activity and a decline of performance in parameters related to attention in the 5CSRTT. Whether or not these impairments are due to attention deficits or changes in explorative behaviour and activity remains to be investigated. The treatment with atomoxetine had no beneficial effect on the rats’ performance regardless of the DSP4 treatment. The present findings support the role of noradrenaline in modulating attentional processes and call for future studies regarding the effects of atomoxetine on attention in rats.",
keywords = "EXTRACELLULAR DOPAMINE, SELECTIVE ATTENTION, DEFICIT HYPERACTIVITY DISORDER, REACTION-TIME-TASK, DORSAL NORADRENERGIC BUNDLE, CORTICAL COGNITIVE FUNCTION, DEFICIT/HYPERACTIVITY DISORDER, PREFRONTAL CORTEX, LOCUS-COERULEUS, 6-HYDROXYDOPAMINE LESIONS",
author = "J. Hauser and A. Reissmann and T.A. Sontag and Oliver Tucha and K.W. Lange",
year = "2017",
month = "12",
doi = "10.1007/s12402-017-0225-x",
language = "English",
volume = "9",
pages = "253--262",
journal = "ADHD Attention Deficit and Hyperactivity Disorders",
issn = "1866-6116",
publisher = "SPRINGER WIEN",
number = "4",

}

RIS

TY - JOUR

T1 - Effects of atomoxetine on attention in Wistar rats treated with the neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4)

AU - Hauser, J.

AU - Reissmann, A.

AU - Sontag, T.A.

AU - Tucha, Oliver

AU - Lange, K.W.

PY - 2017/12

Y1 - 2017/12

N2 - The aim of the present study was to assess the effects of the neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4), which allows a depletion of noradrenergic terminals in a dose-dependent manner, on attention in rats as measured using the five-choice serial-reaction time task (5CSRTT). In addition, we investigated whether the effects of DSP4 treatment can be reversed by atomoxetine. Atomoxetine is a selective noradrenaline reuptake inhibitor and has been shown to be effective in the treatment of attention deficit hyperactivity disorder. Wistar rats were trained in the 5CSRTT and treated with one of the three doses of DSP4 (10, 20 or 50 mg/kg) or saline. Following DSP4 treatment, rats were injected with three doses of atomoxetine (0.1, 0.5 or 1 mg/kg) or saline and tested in the 5CSRTT. The treatment with DSP4 caused a reduction in activity and a decline of performance in parameters related to attention in the 5CSRTT. Whether or not these impairments are due to attention deficits or changes in explorative behaviour and activity remains to be investigated. The treatment with atomoxetine had no beneficial effect on the rats’ performance regardless of the DSP4 treatment. The present findings support the role of noradrenaline in modulating attentional processes and call for future studies regarding the effects of atomoxetine on attention in rats.

AB - The aim of the present study was to assess the effects of the neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4), which allows a depletion of noradrenergic terminals in a dose-dependent manner, on attention in rats as measured using the five-choice serial-reaction time task (5CSRTT). In addition, we investigated whether the effects of DSP4 treatment can be reversed by atomoxetine. Atomoxetine is a selective noradrenaline reuptake inhibitor and has been shown to be effective in the treatment of attention deficit hyperactivity disorder. Wistar rats were trained in the 5CSRTT and treated with one of the three doses of DSP4 (10, 20 or 50 mg/kg) or saline. Following DSP4 treatment, rats were injected with three doses of atomoxetine (0.1, 0.5 or 1 mg/kg) or saline and tested in the 5CSRTT. The treatment with DSP4 caused a reduction in activity and a decline of performance in parameters related to attention in the 5CSRTT. Whether or not these impairments are due to attention deficits or changes in explorative behaviour and activity remains to be investigated. The treatment with atomoxetine had no beneficial effect on the rats’ performance regardless of the DSP4 treatment. The present findings support the role of noradrenaline in modulating attentional processes and call for future studies regarding the effects of atomoxetine on attention in rats.

KW - EXTRACELLULAR DOPAMINE

KW - SELECTIVE ATTENTION

KW - DEFICIT HYPERACTIVITY DISORDER

KW - REACTION-TIME-TASK

KW - DORSAL NORADRENERGIC BUNDLE

KW - CORTICAL COGNITIVE FUNCTION

KW - DEFICIT/HYPERACTIVITY DISORDER

KW - PREFRONTAL CORTEX

KW - LOCUS-COERULEUS

KW - 6-HYDROXYDOPAMINE LESIONS

U2 - 10.1007/s12402-017-0225-x

DO - 10.1007/s12402-017-0225-x

M3 - Article

VL - 9

SP - 253

EP - 262

JO - ADHD Attention Deficit and Hyperactivity Disorders

JF - ADHD Attention Deficit and Hyperactivity Disorders

SN - 1866-6116

IS - 4

ER -

ID: 54832052