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Effects of atomoxetine on attention in Wistar rats treated with the neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4)

Hauser, J., Reissmann, A., Sontag, T. A., Tucha, O. & Lange, K. W., Dec-2017, In : ADHD Attention Deficit and Hyperactivity Disorders. 9, 4, p. 253-262 10 p.

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  • Effects of atomoxetine on attention in Wistar rats treated

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DOI

The aim of the present study was to assess the effects of the neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4), which allows a depletion of noradrenergic terminals in a dose-dependent manner, on attention in rats as measured using the five-choice serial-reaction time task (5CSRTT). In addition, we investigated whether the effects of DSP4 treatment can be reversed by atomoxetine. Atomoxetine is a selective noradrenaline reuptake inhibitor and has been shown to be effective in the treatment of attention deficit hyperactivity disorder. Wistar rats were trained in the 5CSRTT and treated with one of the three doses of DSP4 (10, 20 or 50 mg/kg) or saline. Following DSP4 treatment, rats were injected with three doses of atomoxetine (0.1, 0.5 or 1 mg/kg) or saline and tested in the 5CSRTT. The treatment with DSP4 caused a reduction in activity and a decline of performance in parameters related to attention in the 5CSRTT. Whether or not these impairments are due to attention deficits or changes in explorative behaviour and activity remains to be investigated. The treatment with atomoxetine had no beneficial effect on the rats’ performance regardless of the DSP4 treatment. The present findings support the role of noradrenaline in modulating attentional processes and call for future studies regarding the effects of atomoxetine on attention in rats.
Original languageEnglish
Pages (from-to)253-262
Number of pages10
JournalADHD Attention Deficit and Hyperactivity Disorders
Volume9
Issue number4
Early online date14-Mar-2017
Publication statusPublished - Dec-2017

    Keywords

  • EXTRACELLULAR DOPAMINE, SELECTIVE ATTENTION, DEFICIT HYPERACTIVITY DISORDER, REACTION-TIME-TASK, DORSAL NORADRENERGIC BUNDLE, CORTICAL COGNITIVE FUNCTION, DEFICIT/HYPERACTIVITY DISORDER, PREFRONTAL CORTEX, LOCUS-COERULEUS, 6-HYDROXYDOPAMINE LESIONS

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