Publication

Effects of aripiprazole versus risperidone on brain activation during planning and social-emotional evaluation in schizophrenia: A single-blind randomized exploratory study

Liemburg, E. J., van Es, F., Knegtering, H. & Aleman, A., 3-Oct-2017, In : Progress in Neuro-Psychopharmacology & Biological Psychiatry. 79, Part B, p. 112-119 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Liemburg, E. J., van Es, F., Knegtering, H., & Aleman, A. (2017). Effects of aripiprazole versus risperidone on brain activation during planning and social-emotional evaluation in schizophrenia: A single-blind randomized exploratory study. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 79, Part B, 112-119. https://doi.org/10.1016/j.pnpbp.2017.05.022

Author

Liemburg, Edith J. ; van Es, Frank ; Knegtering, Henderikus ; Aleman, Andre. / Effects of aripiprazole versus risperidone on brain activation during planning and social-emotional evaluation in schizophrenia : A single-blind randomized exploratory study. In: Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2017 ; Vol. 79, Part B. pp. 112-119.

Harvard

Liemburg, EJ, van Es, F, Knegtering, H & Aleman, A 2017, 'Effects of aripiprazole versus risperidone on brain activation during planning and social-emotional evaluation in schizophrenia: A single-blind randomized exploratory study', Progress in Neuro-Psychopharmacology & Biological Psychiatry, vol. 79, Part B, pp. 112-119. https://doi.org/10.1016/j.pnpbp.2017.05.022

Standard

Effects of aripiprazole versus risperidone on brain activation during planning and social-emotional evaluation in schizophrenia : A single-blind randomized exploratory study. / Liemburg, Edith J.; van Es, Frank; Knegtering, Henderikus; Aleman, Andre.

In: Progress in Neuro-Psychopharmacology & Biological Psychiatry, Vol. 79, Part B, 03.10.2017, p. 112-119.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Liemburg EJ, van Es F, Knegtering H, Aleman A. Effects of aripiprazole versus risperidone on brain activation during planning and social-emotional evaluation in schizophrenia: A single-blind randomized exploratory study. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2017 Oct 3;79, Part B:112-119. https://doi.org/10.1016/j.pnpbp.2017.05.022


BibTeX

@article{e58c75c25cbf4aa7a3d32260b935d646,
title = "Effects of aripiprazole versus risperidone on brain activation during planning and social-emotional evaluation in schizophrenia: A single-blind randomized exploratory study",
abstract = "Impaired function of prefrontal brain networks may be the source of both negative symptoms and neurocognitive problems in psychotic disorders. Whereas most antipsychotics may decrease prefrontal activation, the partial dopamine D2-receptor agonist aripiprazole is hypothesized to improve prefrontal function. This study investigated whether patients with a psychotic disorder would show stronger activation of prefrontal areas and associated regions after treatment with aripiprazole compared to risperidone treatment.In this exploratory pharmacological neuroimaging study, 24 patients were randomly assigned to either aripiprazole or risperidone. At baseline and after nine weeks treatment they underwent an interview and MRI session. Here we report on brain activation (measured with arterial spin labeling) during performance of two tasks, the Tower of London and the Wall of Faces.Aripiprazole treatment decreased activation of the middle frontal, superior frontal and occipital gyrus (ToL) and medial temporal and inferior frontal gyrus, putamen and cuneus (WoF), while activation increased after risperidone. Activation increased in the ventral anterior cingulate and posterior insula (ToL), and superior frontal, superior temporal and precentral gyrus (WoF) after aripiprazole treatment and decreased after risperidone. Both treatment groups had increased ventral insula activation (ToL) and middle temporal gyrus (WoF), and decreased occipital cortex, precuneus and caudate head activation (ToL) activation.In conclusion, patients treated with aripiprazole may need less frontal resources for planning performance and may show increased frontotemporal and frontostriatal reactivity to emotional stimuli. More research is needed to corroborate and extend these preliminary findings.",
keywords = "Antipsychotic, Prefrontal, Neuroimaging, Psychotic disorders, WORKING-MEMORY, PREFRONTAL CORTEX, 1ST-EPISODE SCHIZOPHRENIA, ANTIPSYCHOTIC TREATMENT, FUNCTIONAL MRI, NAIVE PATIENTS, LONDON, TOWER, HALOPERIDOL, COGNITION",
author = "Liemburg, {Edith J.} and {van Es}, Frank and Henderikus Knegtering and Andre Aleman",
year = "2017",
month = "10",
day = "3",
doi = "10.1016/j.pnpbp.2017.05.022",
language = "English",
volume = "79, Part B",
pages = "112--119",
journal = "Progress in Neuro-Psychopharmacology & Biological Psychiatry",
issn = "1878-4216",
publisher = "PERGAMON-ELSEVIER SCIENCE LTD",

}

RIS

TY - JOUR

T1 - Effects of aripiprazole versus risperidone on brain activation during planning and social-emotional evaluation in schizophrenia

T2 - A single-blind randomized exploratory study

AU - Liemburg, Edith J.

AU - van Es, Frank

AU - Knegtering, Henderikus

AU - Aleman, Andre

PY - 2017/10/3

Y1 - 2017/10/3

N2 - Impaired function of prefrontal brain networks may be the source of both negative symptoms and neurocognitive problems in psychotic disorders. Whereas most antipsychotics may decrease prefrontal activation, the partial dopamine D2-receptor agonist aripiprazole is hypothesized to improve prefrontal function. This study investigated whether patients with a psychotic disorder would show stronger activation of prefrontal areas and associated regions after treatment with aripiprazole compared to risperidone treatment.In this exploratory pharmacological neuroimaging study, 24 patients were randomly assigned to either aripiprazole or risperidone. At baseline and after nine weeks treatment they underwent an interview and MRI session. Here we report on brain activation (measured with arterial spin labeling) during performance of two tasks, the Tower of London and the Wall of Faces.Aripiprazole treatment decreased activation of the middle frontal, superior frontal and occipital gyrus (ToL) and medial temporal and inferior frontal gyrus, putamen and cuneus (WoF), while activation increased after risperidone. Activation increased in the ventral anterior cingulate and posterior insula (ToL), and superior frontal, superior temporal and precentral gyrus (WoF) after aripiprazole treatment and decreased after risperidone. Both treatment groups had increased ventral insula activation (ToL) and middle temporal gyrus (WoF), and decreased occipital cortex, precuneus and caudate head activation (ToL) activation.In conclusion, patients treated with aripiprazole may need less frontal resources for planning performance and may show increased frontotemporal and frontostriatal reactivity to emotional stimuli. More research is needed to corroborate and extend these preliminary findings.

AB - Impaired function of prefrontal brain networks may be the source of both negative symptoms and neurocognitive problems in psychotic disorders. Whereas most antipsychotics may decrease prefrontal activation, the partial dopamine D2-receptor agonist aripiprazole is hypothesized to improve prefrontal function. This study investigated whether patients with a psychotic disorder would show stronger activation of prefrontal areas and associated regions after treatment with aripiprazole compared to risperidone treatment.In this exploratory pharmacological neuroimaging study, 24 patients were randomly assigned to either aripiprazole or risperidone. At baseline and after nine weeks treatment they underwent an interview and MRI session. Here we report on brain activation (measured with arterial spin labeling) during performance of two tasks, the Tower of London and the Wall of Faces.Aripiprazole treatment decreased activation of the middle frontal, superior frontal and occipital gyrus (ToL) and medial temporal and inferior frontal gyrus, putamen and cuneus (WoF), while activation increased after risperidone. Activation increased in the ventral anterior cingulate and posterior insula (ToL), and superior frontal, superior temporal and precentral gyrus (WoF) after aripiprazole treatment and decreased after risperidone. Both treatment groups had increased ventral insula activation (ToL) and middle temporal gyrus (WoF), and decreased occipital cortex, precuneus and caudate head activation (ToL) activation.In conclusion, patients treated with aripiprazole may need less frontal resources for planning performance and may show increased frontotemporal and frontostriatal reactivity to emotional stimuli. More research is needed to corroborate and extend these preliminary findings.

KW - Antipsychotic

KW - Prefrontal

KW - Neuroimaging

KW - Psychotic disorders

KW - WORKING-MEMORY

KW - PREFRONTAL CORTEX

KW - 1ST-EPISODE SCHIZOPHRENIA

KW - ANTIPSYCHOTIC TREATMENT

KW - FUNCTIONAL MRI

KW - NAIVE PATIENTS

KW - LONDON

KW - TOWER

KW - HALOPERIDOL

KW - COGNITION

U2 - 10.1016/j.pnpbp.2017.05.022

DO - 10.1016/j.pnpbp.2017.05.022

M3 - Article

VL - 79, Part B

SP - 112

EP - 119

JO - Progress in Neuro-Psychopharmacology & Biological Psychiatry

JF - Progress in Neuro-Psychopharmacology & Biological Psychiatry

SN - 1878-4216

ER -

ID: 49856266