Effects and moderators of coping skills training on symptoms of depression and anxiety in patients with cancer: Aggregate data and individual patient data meta-analysesBuffart, L. M., Schreurs, M. A. C., Abrahams, H. J. G., Kalter, J., Aaronson, N. K., Jacobsen, P. B., Newton, R. U., Courneya, K. S., Armes, J., Arving, C., Braamse, A. M., Brandberg, Y., Dekker, J., Ferguson, R. J., Gielissen, M. F., Glimelius, B., Goedendorp, M. M., Graves, K. D., Heiney, S. P., Horne, R., Hunter, M. S., Johansson, B., Northouse, L. L., Oldenburg, H. S., Prins, J. B., Savard, J., van Beurden, M., van den Berg, S. W., Brug, J., Knoop, H. & Verdonck-de Leeuw, I. M., Aug-2020, In : Clinical Psychology Review. 80, 14 p., 101882.
Research output: Contribution to journal › Review article › Academic › peer-review
PURPOSE: This study evaluated the effects of coping skills training (CST) on symptoms of depression and anxiety in cancer patients, and investigated moderators of the effects.
METHODS: Overall effects and intervention-related moderators were studied in meta-analyses of pooled aggregate data from 38 randomized controlled trials (RCTs). Patient-related moderators were examined using linear mixed-effect models with interaction tests on pooled individual patient data (n = 1953) from 15 of the RCTs.
RESULTS: CST had a statistically significant but small effect on depression (g = -0.31,95% confidence interval (CI) = -0.40;-0.22) and anxiety (g = -0.32,95%CI = -0.41;-0.24) symptoms. Effects on depression symptoms were significantly larger for interventions delivered face-to-face (p = .003), led by a psychologist (p = .02) and targeted to patients with psychological distress (p = .002). Significantly larger reductions in anxiety symptoms were found in younger patients (pinteraction < 0.025), with the largest reductions in patients <50 years (β = -0.31,95%CI = -0.44;-0.18) and no significant effects in patients ≥70 years. Effects of CST on depression (β = -0.16,95%CI = -0.25;-0.07) and anxiety (β = -0.24,95%CI = -0.33;-0.14) symptoms were significant in patients who received chemotherapy but not in patients who did not (pinteraction < 0.05).
CONCLUSIONS: CST significantly reduced symptoms of depression and anxiety in cancer patients, and particularly when delivered face-to-face, provided by a psychologist, targeted to patients with psychological distress, and given to patients who were younger and received chemotherapy.
|Number of pages||14|
|Journal||Clinical Psychology Review|
|Early online date||25-Jun-2020|
|Publication status||Published - Aug-2020|