Publication

Effector-Triggered Self-Replication in Coupled Subsystems

Komáromy, D., Tezcan, M., Schaeffer, G., Marić, I. & Otto, S., 13-Nov-2017, In : Angewandte Chemie - International Edition. 56, 46, p. 14658-14662 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Komáromy, D., Tezcan, M., Schaeffer, G., Marić, I., & Otto, S. (2017). Effector-Triggered Self-Replication in Coupled Subsystems. Angewandte Chemie - International Edition, 56(46), 14658-14662. https://doi.org/10.1002/anie.201707191

Author

Komáromy, Dávid ; Tezcan, Meniz ; Schaeffer, Gaël ; Marić, Ivana ; Otto, Sijbren. / Effector-Triggered Self-Replication in Coupled Subsystems. In: Angewandte Chemie - International Edition. 2017 ; Vol. 56, No. 46. pp. 14658-14662.

Harvard

Komáromy, D, Tezcan, M, Schaeffer, G, Marić, I & Otto, S 2017, 'Effector-Triggered Self-Replication in Coupled Subsystems', Angewandte Chemie - International Edition, vol. 56, no. 46, pp. 14658-14662. https://doi.org/10.1002/anie.201707191

Standard

Effector-Triggered Self-Replication in Coupled Subsystems. / Komáromy, Dávid; Tezcan, Meniz; Schaeffer, Gaël; Marić, Ivana; Otto, Sijbren.

In: Angewandte Chemie - International Edition, Vol. 56, No. 46, 13.11.2017, p. 14658-14662.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Komáromy D, Tezcan M, Schaeffer G, Marić I, Otto S. Effector-Triggered Self-Replication in Coupled Subsystems. Angewandte Chemie - International Edition. 2017 Nov 13;56(46):14658-14662. https://doi.org/10.1002/anie.201707191


BibTeX

@article{5dcf74f8f0b84c6b9a52b64840f67644,
title = "Effector-Triggered Self-Replication in Coupled Subsystems",
abstract = "In living systems processes like genome duplication and cell division are carefully synchronized through subsystem coupling. If we are to create life de novo, similar control over essential processes such as self-replication need to be developed. Here we report that coupling two dynamic combinatorial subsystems, featuring two separate building blocks, enables effector-mediated control over self-replication. The subsystem based on the first building block shows only self-replication, whereas that based on the second one is solely responsive toward a specific external effector molecule. Mixing the subsystems arrests replication until the effector molecule is added, resulting in the formation of a host-effector complex and the liberation of the building block that subsequently engages in self-replication. The onset, rate and extent of self-replication is controlled by the amount of effector present.",
keywords = "Journal Article, DYNAMIC COMBINATORIAL LIBRARIES, SYSTEMS CHEMISTRY, EMERGENCE, NETWORKS, EVOLUTION, CELLS",
author = "D{\'a}vid Kom{\'a}romy and Meniz Tezcan and Ga{\"e}l Schaeffer and Ivana Mari{\'c} and Sijbren Otto",
note = "{\textcopyright} 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.",
year = "2017",
month = nov,
day = "13",
doi = "10.1002/anie.201707191",
language = "English",
volume = "56",
pages = "14658--14662",
journal = "Angewandte Chemie - International Edition",
issn = "1433-7851",
publisher = "WILEY-V C H VERLAG GMBH",
number = "46",

}

RIS

TY - JOUR

T1 - Effector-Triggered Self-Replication in Coupled Subsystems

AU - Komáromy, Dávid

AU - Tezcan, Meniz

AU - Schaeffer, Gaël

AU - Marić, Ivana

AU - Otto, Sijbren

N1 - © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

PY - 2017/11/13

Y1 - 2017/11/13

N2 - In living systems processes like genome duplication and cell division are carefully synchronized through subsystem coupling. If we are to create life de novo, similar control over essential processes such as self-replication need to be developed. Here we report that coupling two dynamic combinatorial subsystems, featuring two separate building blocks, enables effector-mediated control over self-replication. The subsystem based on the first building block shows only self-replication, whereas that based on the second one is solely responsive toward a specific external effector molecule. Mixing the subsystems arrests replication until the effector molecule is added, resulting in the formation of a host-effector complex and the liberation of the building block that subsequently engages in self-replication. The onset, rate and extent of self-replication is controlled by the amount of effector present.

AB - In living systems processes like genome duplication and cell division are carefully synchronized through subsystem coupling. If we are to create life de novo, similar control over essential processes such as self-replication need to be developed. Here we report that coupling two dynamic combinatorial subsystems, featuring two separate building blocks, enables effector-mediated control over self-replication. The subsystem based on the first building block shows only self-replication, whereas that based on the second one is solely responsive toward a specific external effector molecule. Mixing the subsystems arrests replication until the effector molecule is added, resulting in the formation of a host-effector complex and the liberation of the building block that subsequently engages in self-replication. The onset, rate and extent of self-replication is controlled by the amount of effector present.

KW - Journal Article

KW - DYNAMIC COMBINATORIAL LIBRARIES

KW - SYSTEMS CHEMISTRY

KW - EMERGENCE

KW - NETWORKS

KW - EVOLUTION

KW - CELLS

U2 - 10.1002/anie.201707191

DO - 10.1002/anie.201707191

M3 - Article

C2 - 28892230

VL - 56

SP - 14658

EP - 14662

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

SN - 1433-7851

IS - 46

ER -

ID: 49204008