Publication

Effectiveness of seasonal influenza vaccine in community-dwelling elderly people: a meta-analysis of test-negative design case-control studies

Darvishian, M., Bijlsma, M. J., Hak, E. & van den Heuvel, E. R., Dec-2014, In : Lancet Infectious Diseases. 14, 12, p. 1228-1239 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Darvishian, M., Bijlsma, M. J., Hak, E., & van den Heuvel, E. R. (2014). Effectiveness of seasonal influenza vaccine in community-dwelling elderly people: a meta-analysis of test-negative design case-control studies. Lancet Infectious Diseases, 14(12), 1228-1239. https://doi.org/10.1016/S1473-3099(14)70960-0

Author

Darvishian, Maryam ; Bijlsma, Maarten J. ; Hak, Eelko ; van den Heuvel, Edwin R. / Effectiveness of seasonal influenza vaccine in community-dwelling elderly people : a meta-analysis of test-negative design case-control studies. In: Lancet Infectious Diseases. 2014 ; Vol. 14, No. 12. pp. 1228-1239.

Harvard

Darvishian, M, Bijlsma, MJ, Hak, E & van den Heuvel, ER 2014, 'Effectiveness of seasonal influenza vaccine in community-dwelling elderly people: a meta-analysis of test-negative design case-control studies', Lancet Infectious Diseases, vol. 14, no. 12, pp. 1228-1239. https://doi.org/10.1016/S1473-3099(14)70960-0

Standard

Effectiveness of seasonal influenza vaccine in community-dwelling elderly people : a meta-analysis of test-negative design case-control studies. / Darvishian, Maryam; Bijlsma, Maarten J.; Hak, Eelko; van den Heuvel, Edwin R.

In: Lancet Infectious Diseases, Vol. 14, No. 12, 12.2014, p. 1228-1239.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Darvishian M, Bijlsma MJ, Hak E, van den Heuvel ER. Effectiveness of seasonal influenza vaccine in community-dwelling elderly people: a meta-analysis of test-negative design case-control studies. Lancet Infectious Diseases. 2014 Dec;14(12):1228-1239. https://doi.org/10.1016/S1473-3099(14)70960-0


BibTeX

@article{13452bfe62a34ba7a557429936cf169a,
title = "Effectiveness of seasonal influenza vaccine in community-dwelling elderly people: a meta-analysis of test-negative design case-control studies",
abstract = "Background The application of test-negative design case-control studies to assess the effectiveness of influenza vaccine has increased substantially in the past few years. The validity of these studies is predicated on the assumption that confounding bias by risk factors is limited by design. We aimed to assess the effectiveness of influenza vaccine in a high-risk group of elderly people.Methods We searched the Cochrane library, Medline, and Embase up to July 13,2014, for test-negative design casecontrol studies that assessed the effectiveness of seasonal influenza vaccine against laboratory confirmed influenza in community-dwelling people aged 60 years or older. We used generalised linear mixed models, adapted for test-negative design case-control studies, to estimate vaccine effectiveness according to vaccine match and epidemic conditions.Findings 35 test-negative design case-control studies with 53 datasets met inclusion criteria. Seasonal influenza vaccine was not significantly effective during local virus activity, irrespective of vaccine match or mismatch to the circulating viruses. Vaccination was significantly effective against laboratory confirmed influenza during sporadic activity (odds ratio [OR] 0.69, 95% CI 0.48-0.99) only when the vaccine matched. Additionally, vaccination was significantly effective during regional (match: OR 0-42,95% CI 0.30-0.60; mismatch: OR 0.57,95% CI 0.41-0.79) and widespread (match: 0-54,0.46-0.62; mismatch: OR 0.72,95% CI 0.60-0.85) outbreaks.Interpretation Our findings show that in elderly people, irrespective of vaccine match, seasonal influenza vaccination is effective against laboratory confirmed influenza during epidemic seasons. Efforts should be renewed worldwide to further increase uptake of the influenza vaccine in the elderly population.",
keywords = "LABORATORY-CONFIRMED INFLUENZA, SURVEILLANCE NETWORK, PREVENTING INFLUENZA, SPARSE DATA, TRIVALENT, HOSPITALIZATIONS, SPAIN, CANADA, POPULATION, PROTECTION",
author = "Maryam Darvishian and Bijlsma, {Maarten J.} and Eelko Hak and {van den Heuvel}, {Edwin R.}",
note = "Copyright {\textcopyright} 2014 Elsevier Ltd. All rights reserved.",
year = "2014",
month = dec,
doi = "10.1016/S1473-3099(14)70960-0",
language = "English",
volume = "14",
pages = "1228--1239",
journal = "Lancet Infectious Diseases",
issn = "1473-3099",
publisher = "ELSEVIER SCI LTD",
number = "12",

}

RIS

TY - JOUR

T1 - Effectiveness of seasonal influenza vaccine in community-dwelling elderly people

T2 - a meta-analysis of test-negative design case-control studies

AU - Darvishian, Maryam

AU - Bijlsma, Maarten J.

AU - Hak, Eelko

AU - van den Heuvel, Edwin R.

N1 - Copyright © 2014 Elsevier Ltd. All rights reserved.

PY - 2014/12

Y1 - 2014/12

N2 - Background The application of test-negative design case-control studies to assess the effectiveness of influenza vaccine has increased substantially in the past few years. The validity of these studies is predicated on the assumption that confounding bias by risk factors is limited by design. We aimed to assess the effectiveness of influenza vaccine in a high-risk group of elderly people.Methods We searched the Cochrane library, Medline, and Embase up to July 13,2014, for test-negative design casecontrol studies that assessed the effectiveness of seasonal influenza vaccine against laboratory confirmed influenza in community-dwelling people aged 60 years or older. We used generalised linear mixed models, adapted for test-negative design case-control studies, to estimate vaccine effectiveness according to vaccine match and epidemic conditions.Findings 35 test-negative design case-control studies with 53 datasets met inclusion criteria. Seasonal influenza vaccine was not significantly effective during local virus activity, irrespective of vaccine match or mismatch to the circulating viruses. Vaccination was significantly effective against laboratory confirmed influenza during sporadic activity (odds ratio [OR] 0.69, 95% CI 0.48-0.99) only when the vaccine matched. Additionally, vaccination was significantly effective during regional (match: OR 0-42,95% CI 0.30-0.60; mismatch: OR 0.57,95% CI 0.41-0.79) and widespread (match: 0-54,0.46-0.62; mismatch: OR 0.72,95% CI 0.60-0.85) outbreaks.Interpretation Our findings show that in elderly people, irrespective of vaccine match, seasonal influenza vaccination is effective against laboratory confirmed influenza during epidemic seasons. Efforts should be renewed worldwide to further increase uptake of the influenza vaccine in the elderly population.

AB - Background The application of test-negative design case-control studies to assess the effectiveness of influenza vaccine has increased substantially in the past few years. The validity of these studies is predicated on the assumption that confounding bias by risk factors is limited by design. We aimed to assess the effectiveness of influenza vaccine in a high-risk group of elderly people.Methods We searched the Cochrane library, Medline, and Embase up to July 13,2014, for test-negative design casecontrol studies that assessed the effectiveness of seasonal influenza vaccine against laboratory confirmed influenza in community-dwelling people aged 60 years or older. We used generalised linear mixed models, adapted for test-negative design case-control studies, to estimate vaccine effectiveness according to vaccine match and epidemic conditions.Findings 35 test-negative design case-control studies with 53 datasets met inclusion criteria. Seasonal influenza vaccine was not significantly effective during local virus activity, irrespective of vaccine match or mismatch to the circulating viruses. Vaccination was significantly effective against laboratory confirmed influenza during sporadic activity (odds ratio [OR] 0.69, 95% CI 0.48-0.99) only when the vaccine matched. Additionally, vaccination was significantly effective during regional (match: OR 0-42,95% CI 0.30-0.60; mismatch: OR 0.57,95% CI 0.41-0.79) and widespread (match: 0-54,0.46-0.62; mismatch: OR 0.72,95% CI 0.60-0.85) outbreaks.Interpretation Our findings show that in elderly people, irrespective of vaccine match, seasonal influenza vaccination is effective against laboratory confirmed influenza during epidemic seasons. Efforts should be renewed worldwide to further increase uptake of the influenza vaccine in the elderly population.

KW - LABORATORY-CONFIRMED INFLUENZA

KW - SURVEILLANCE NETWORK

KW - PREVENTING INFLUENZA

KW - SPARSE DATA

KW - TRIVALENT

KW - HOSPITALIZATIONS

KW - SPAIN

KW - CANADA

KW - POPULATION

KW - PROTECTION

U2 - 10.1016/S1473-3099(14)70960-0

DO - 10.1016/S1473-3099(14)70960-0

M3 - Article

C2 - 25455990

VL - 14

SP - 1228

EP - 1239

JO - Lancet Infectious Diseases

JF - Lancet Infectious Diseases

SN - 1473-3099

IS - 12

ER -

ID: 15004460