Effectiveness of Cognitive-Behavioral Therapy on Quality of Life, Anxiety, and Depressive Symptoms Among Patients With Inflammatory Bowel Disease: A Multicenter Randomized Controlled Trial

Evertsz, F. B., Sprangers, M. A. G., Sitnikova, K., Stokkers, P. C. F., Ponsioen, C. Y., Bartelsman, J. F. W. M., van Bodegraven, A. A., Fischer, S., Depla, A. C. T. M., Mallant, R. C., Sanderman, R., Burger, H. & Bockting, C. L. H. Sep-2017 In : Journal of Consulting and Clinical Psychology. 85, 9, p. 918-925 8 p.

Research output: Scientific - peer-reviewArticle

Objective: Inflammatory bowel disease (IBD) is characterized by a low level of quality of life (QoL) and a high prevalence of anxiety and depression, especially in patients with poor QoL. We examined the effect of IBD-specific cognitive-behavioral therapy (CBT) on QoL, anxiety, and depression in IBD patients with poor mental QoL. Method: This study is a parallel-group multicenter randomized controlled trial. One hundred eighteen IBD patients with a low level of QoL (score = 5 sessions). CBT had a positive effect on disease-specific-QoL (Cohen's d = .64 for IBDQ total score), depression (Cohen's d = .48 for HADS-D and.78 for CES-D), anxiety (Cohen's d = .58 for HADS-A), and generic QoL (Cohen's d = 1.08 for Mental Component Summary of the SF-36; all ps <.01). Conclusions: IBD-specific CBT is effective in improving QoL and in decreasing anxiety and depression in IBD patients with poor QoL. Clinicians should incorporate screening on poor mental QoL and consider offering CBT.

What is the public health significance of this article?

Given that a substantial proportion of people with chronic somatic disorders have a high prevalence of psychiatric disorders, it is of relevance to examine whether psychological interventions are effective in this comorbid group. In a specific chronic somatic disorder, inflammatory bowel disease (IBD), 'IBD-specific CBT' has a promising effect on QoL, anxiety and depressive symptoms.

Original languageEnglish
Pages (from-to)918-925
Number of pages8
JournalJournal of Consulting and Clinical Psychology
Issue number9
StatePublished - Sep-2017


  • cognitive-behavioral therapy, inflammatory bowel disease, quality of life, anxiety, depression, FOLLOW-UP, PSYCHOTHERAPY, MOOD

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