Publication

Effect of sera from patients with Hodgkin's disease on normal donor lymphocytes containing parallel tubular structures

Smit, J. W., Blom, N. R., van Luyn, M. J. A., van Imhoff, G. W. & Halie, M. R., 1984, In : Blut. 48, 2, p. 109-115 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Smit, J. W., Blom, N. R., van Luyn, M. J. A., van Imhoff, G. W., & Halie, M. R. (1984). Effect of sera from patients with Hodgkin's disease on normal donor lymphocytes containing parallel tubular structures. Blut, 48(2), 109-115. https://doi.org/10.1007/BF00320037

Author

Smit, J. W. ; Blom, N. R. ; van Luyn, M. J. A. ; van Imhoff, G. W. ; Halie, M. R. / Effect of sera from patients with Hodgkin's disease on normal donor lymphocytes containing parallel tubular structures. In: Blut. 1984 ; Vol. 48, No. 2. pp. 109-115.

Harvard

Smit, JW, Blom, NR, van Luyn, MJA, van Imhoff, GW & Halie, MR 1984, 'Effect of sera from patients with Hodgkin's disease on normal donor lymphocytes containing parallel tubular structures', Blut, vol. 48, no. 2, pp. 109-115. https://doi.org/10.1007/BF00320037

Standard

Effect of sera from patients with Hodgkin's disease on normal donor lymphocytes containing parallel tubular structures. / Smit, J. W.; Blom, N. R.; van Luyn, M. J. A.; van Imhoff, G. W.; Halie, M. R.

In: Blut, Vol. 48, No. 2, 1984, p. 109-115.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Smit JW, Blom NR, van Luyn MJA, van Imhoff GW, Halie MR. Effect of sera from patients with Hodgkin's disease on normal donor lymphocytes containing parallel tubular structures. Blut. 1984;48(2):109-115. https://doi.org/10.1007/BF00320037


BibTeX

@article{bc2dd550e925410aa9536e7df6c3a614,
title = "Effect of sera from patients with Hodgkin's disease on normal donor lymphocytes containing parallel tubular structures",
abstract = "Normal donor peripheral blood mononuclear cells incubated for 24 h with sera from patients with Hodgkin's disease were investigated by electron microscopy for the presence of parallel tubular structures (PTS) and/or amorphous electrondense granules (large granular lymphocytes = LGL). In comparison with normal human serum, 14 out of 29 sera of the patients induced a marked increase in the percentage of LGL. From a limited number of experiments it was likely that this increase is paralleled by an increase in Fcγ receptor-bearing cells after the incubation. This serum effect did not show a correlation with the number of Fcγ receptor-positive lymphocytes in the peripheral blood of the patients.A difference in the induction effect could be demonstrated between the sera from patients with a favourable and those with an unfavourable clinical course, but this distinction was not absolute. The presence of absence of splenic involvement by Hodgkin's disease does not apparently influence the effect of the sera.From experiments using sera positive for immune complexes or anti-Epstein-Barr virus antibodies, it seems unlikely that these factors are responsible for the observed increase in LGL.",
author = "Smit, {J. W.} and Blom, {N. R.} and {van Luyn}, {M. J. A.} and {van Imhoff}, {G. W.} and Halie, {M. R.}",
year = "1984",
doi = "10.1007/BF00320037",
language = "English",
volume = "48",
pages = "109--115",
journal = "Blut",
issn = "0006-5242",
number = "2",

}

RIS

TY - JOUR

T1 - Effect of sera from patients with Hodgkin's disease on normal donor lymphocytes containing parallel tubular structures

AU - Smit, J. W.

AU - Blom, N. R.

AU - van Luyn, M. J. A.

AU - van Imhoff, G. W.

AU - Halie, M. R.

PY - 1984

Y1 - 1984

N2 - Normal donor peripheral blood mononuclear cells incubated for 24 h with sera from patients with Hodgkin's disease were investigated by electron microscopy for the presence of parallel tubular structures (PTS) and/or amorphous electrondense granules (large granular lymphocytes = LGL). In comparison with normal human serum, 14 out of 29 sera of the patients induced a marked increase in the percentage of LGL. From a limited number of experiments it was likely that this increase is paralleled by an increase in Fcγ receptor-bearing cells after the incubation. This serum effect did not show a correlation with the number of Fcγ receptor-positive lymphocytes in the peripheral blood of the patients.A difference in the induction effect could be demonstrated between the sera from patients with a favourable and those with an unfavourable clinical course, but this distinction was not absolute. The presence of absence of splenic involvement by Hodgkin's disease does not apparently influence the effect of the sera.From experiments using sera positive for immune complexes or anti-Epstein-Barr virus antibodies, it seems unlikely that these factors are responsible for the observed increase in LGL.

AB - Normal donor peripheral blood mononuclear cells incubated for 24 h with sera from patients with Hodgkin's disease were investigated by electron microscopy for the presence of parallel tubular structures (PTS) and/or amorphous electrondense granules (large granular lymphocytes = LGL). In comparison with normal human serum, 14 out of 29 sera of the patients induced a marked increase in the percentage of LGL. From a limited number of experiments it was likely that this increase is paralleled by an increase in Fcγ receptor-bearing cells after the incubation. This serum effect did not show a correlation with the number of Fcγ receptor-positive lymphocytes in the peripheral blood of the patients.A difference in the induction effect could be demonstrated between the sera from patients with a favourable and those with an unfavourable clinical course, but this distinction was not absolute. The presence of absence of splenic involvement by Hodgkin's disease does not apparently influence the effect of the sera.From experiments using sera positive for immune complexes or anti-Epstein-Barr virus antibodies, it seems unlikely that these factors are responsible for the observed increase in LGL.

U2 - 10.1007/BF00320037

DO - 10.1007/BF00320037

M3 - Article

VL - 48

SP - 109

EP - 115

JO - Blut

JF - Blut

SN - 0006-5242

IS - 2

ER -

ID: 6133730