Publication

Effect of Roux-en-Y gastric bypass on the bioavailability of metoprolol from immediate and controlled release tablets: A single oral dose study before and after surgery

Yska, J. P., Wanders, J. T. M., Odigie, B., Apers, J. A., Emous, M., Totté, E. R. E., Boerma, E. C., Ubels, F. L., Woerdenbag, H. J., Frijlink, H. W., Wilffert, B. & Van Roon, E. N., 16-Mar-2019, In : European Journal of Hospital Pharmacy: Science and Practice.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Yska, J. P., Wanders, J. T. M., Odigie, B., Apers, J. A., Emous, M., Totté, E. R. E., ... Van Roon, E. N. (2019). Effect of Roux-en-Y gastric bypass on the bioavailability of metoprolol from immediate and controlled release tablets: A single oral dose study before and after surgery. European Journal of Hospital Pharmacy: Science and Practice. https://doi.org/10.1136/ejhpharm-2018-001804

Author

Yska, Jan Peter ; Wanders, Jacquelien T. M. ; Odigie, Blessing ; Apers, Jan A ; Emous, Marloes ; Totté, Erik R. E. ; Boerma, E Christiaan ; Ubels, Froukje L. ; Woerdenbag, Herman J. ; Frijlink, Henderik W. ; Wilffert, Bob ; Van Roon, Eric N. / Effect of Roux-en-Y gastric bypass on the bioavailability of metoprolol from immediate and controlled release tablets : A single oral dose study before and after surgery. In: European Journal of Hospital Pharmacy: Science and Practice. 2019.

Harvard

Yska, JP, Wanders, JTM, Odigie, B, Apers, JA, Emous, M, Totté, ERE, Boerma, EC, Ubels, FL, Woerdenbag, HJ, Frijlink, HW, Wilffert, B & Van Roon, EN 2019, 'Effect of Roux-en-Y gastric bypass on the bioavailability of metoprolol from immediate and controlled release tablets: A single oral dose study before and after surgery', European Journal of Hospital Pharmacy: Science and Practice. https://doi.org/10.1136/ejhpharm-2018-001804

Standard

Effect of Roux-en-Y gastric bypass on the bioavailability of metoprolol from immediate and controlled release tablets : A single oral dose study before and after surgery. / Yska, Jan Peter; Wanders, Jacquelien T. M.; Odigie, Blessing; Apers, Jan A; Emous, Marloes; Totté, Erik R. E.; Boerma, E Christiaan; Ubels, Froukje L.; Woerdenbag, Herman J.; Frijlink, Henderik W.; Wilffert, Bob; Van Roon, Eric N.

In: European Journal of Hospital Pharmacy: Science and Practice, 16.03.2019.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Yska JP, Wanders JTM, Odigie B, Apers JA, Emous M, Totté ERE et al. Effect of Roux-en-Y gastric bypass on the bioavailability of metoprolol from immediate and controlled release tablets: A single oral dose study before and after surgery. European Journal of Hospital Pharmacy: Science and Practice. 2019 Mar 16. https://doi.org/10.1136/ejhpharm-2018-001804


BibTeX

@article{be6c74742a6e4c1a9b844adeec95a1d5,
title = "Effect of Roux-en-Y gastric bypass on the bioavailability of metoprolol from immediate and controlled release tablets: A single oral dose study before and after surgery",
abstract = "Objective: Roux-en-Y gastric bypass (RYGB) surgery induces major changes in the gastrointestinal tract that may alter the pharmacokinetics of orally administered drugs. Results from pharmacokinetic studies are sparse. This study aimed to investigate the effect of RYGB on the bioavailability of metoprolol from immediate release (IR) and controlled release (CR) tablets in female patient volunteers before and after surgery. Methods: An explorative, two-phase, single oral dose pharmacokinetic study of metoprolol in female patients undergoing RYGB was carried out. The dose was administered twice in each patient, 1 month before and 6 months after surgery. After intake of either 100 mg of metoprolol IR or CR tablet serum concentration-time profiles of metoprolol were determined. The endpoint was the ratio of AUCafter/AUCbefore of metoprolol. Results: Twelve patients were included in the study (metoprolol IR: 7; metoprolol CR: 5). After intake of a metoprolol IR tablet major intraindividual and interindividual differences for area under the serum concentration versus time curve (AUC) of metoprolol before and after surgery were observed (range ratio AUC0-10 hours after/AUC0-10 hours before: 0.74-1.98). For metoprolol CR tablets a significant reduction in bioavailability of metoprolol was observed after surgery (range ratio AUC0-24 hours after/AUC0-24 hours before: 0.43-0.77). Conclusion: RYGB may influence the bioavailability of metoprolol from an IR tablet. The magnitude of changes in bioavailability after RYGB requires close monitoring of patients using metoprolol IR tablets and dose adjustment if deemed necessary. RYGB clearly reduces the bioavailability of metoprolol from a CR tablet. After RYGB clinicians may consider to increase the dose according to clinical response.",
keywords = "bioavailability, controlled release, gastric bypass surgery, immediate release, metoprolol, pharmacokinetics, adult, article, AUC (0-24 h), clinical article, clinician, controlled study, drug therapy, female, human, human tissue, monitoring, oral drug administration, plasma concentration-time curve, Roux-en-Y gastric bypass, tablet, volunteer",
author = "Yska, {Jan Peter} and Wanders, {Jacquelien T. M.} and Blessing Odigie and Apers, {Jan A} and Marloes Emous and Tott{\'e}, {Erik R. E.} and Boerma, {E Christiaan} and Ubels, {Froukje L.} and Woerdenbag, {Herman J.} and Frijlink, {Henderik W.} and Bob Wilffert and {Van Roon}, {Eric N.}",
year = "2019",
month = "3",
day = "16",
doi = "10.1136/ejhpharm-2018-001804",
language = "English",
journal = "European Journal of Hospital Pharmacy: Science and Practice",
issn = "2047-9956",
publisher = "BMJ PUBLISHING GROUP",

}

RIS

TY - JOUR

T1 - Effect of Roux-en-Y gastric bypass on the bioavailability of metoprolol from immediate and controlled release tablets

T2 - A single oral dose study before and after surgery

AU - Yska, Jan Peter

AU - Wanders, Jacquelien T. M.

AU - Odigie, Blessing

AU - Apers, Jan A

AU - Emous, Marloes

AU - Totté, Erik R. E.

AU - Boerma, E Christiaan

AU - Ubels, Froukje L.

AU - Woerdenbag, Herman J.

AU - Frijlink, Henderik W.

AU - Wilffert, Bob

AU - Van Roon, Eric N.

PY - 2019/3/16

Y1 - 2019/3/16

N2 - Objective: Roux-en-Y gastric bypass (RYGB) surgery induces major changes in the gastrointestinal tract that may alter the pharmacokinetics of orally administered drugs. Results from pharmacokinetic studies are sparse. This study aimed to investigate the effect of RYGB on the bioavailability of metoprolol from immediate release (IR) and controlled release (CR) tablets in female patient volunteers before and after surgery. Methods: An explorative, two-phase, single oral dose pharmacokinetic study of metoprolol in female patients undergoing RYGB was carried out. The dose was administered twice in each patient, 1 month before and 6 months after surgery. After intake of either 100 mg of metoprolol IR or CR tablet serum concentration-time profiles of metoprolol were determined. The endpoint was the ratio of AUCafter/AUCbefore of metoprolol. Results: Twelve patients were included in the study (metoprolol IR: 7; metoprolol CR: 5). After intake of a metoprolol IR tablet major intraindividual and interindividual differences for area under the serum concentration versus time curve (AUC) of metoprolol before and after surgery were observed (range ratio AUC0-10 hours after/AUC0-10 hours before: 0.74-1.98). For metoprolol CR tablets a significant reduction in bioavailability of metoprolol was observed after surgery (range ratio AUC0-24 hours after/AUC0-24 hours before: 0.43-0.77). Conclusion: RYGB may influence the bioavailability of metoprolol from an IR tablet. The magnitude of changes in bioavailability after RYGB requires close monitoring of patients using metoprolol IR tablets and dose adjustment if deemed necessary. RYGB clearly reduces the bioavailability of metoprolol from a CR tablet. After RYGB clinicians may consider to increase the dose according to clinical response.

AB - Objective: Roux-en-Y gastric bypass (RYGB) surgery induces major changes in the gastrointestinal tract that may alter the pharmacokinetics of orally administered drugs. Results from pharmacokinetic studies are sparse. This study aimed to investigate the effect of RYGB on the bioavailability of metoprolol from immediate release (IR) and controlled release (CR) tablets in female patient volunteers before and after surgery. Methods: An explorative, two-phase, single oral dose pharmacokinetic study of metoprolol in female patients undergoing RYGB was carried out. The dose was administered twice in each patient, 1 month before and 6 months after surgery. After intake of either 100 mg of metoprolol IR or CR tablet serum concentration-time profiles of metoprolol were determined. The endpoint was the ratio of AUCafter/AUCbefore of metoprolol. Results: Twelve patients were included in the study (metoprolol IR: 7; metoprolol CR: 5). After intake of a metoprolol IR tablet major intraindividual and interindividual differences for area under the serum concentration versus time curve (AUC) of metoprolol before and after surgery were observed (range ratio AUC0-10 hours after/AUC0-10 hours before: 0.74-1.98). For metoprolol CR tablets a significant reduction in bioavailability of metoprolol was observed after surgery (range ratio AUC0-24 hours after/AUC0-24 hours before: 0.43-0.77). Conclusion: RYGB may influence the bioavailability of metoprolol from an IR tablet. The magnitude of changes in bioavailability after RYGB requires close monitoring of patients using metoprolol IR tablets and dose adjustment if deemed necessary. RYGB clearly reduces the bioavailability of metoprolol from a CR tablet. After RYGB clinicians may consider to increase the dose according to clinical response.

KW - bioavailability

KW - controlled release

KW - gastric bypass surgery

KW - immediate release

KW - metoprolol

KW - pharmacokinetics

KW - adult

KW - article

KW - AUC (0-24 h)

KW - clinical article

KW - clinician

KW - controlled study

KW - drug therapy

KW - female

KW - human

KW - human tissue

KW - monitoring

KW - oral drug administration

KW - plasma concentration-time curve

KW - Roux-en-Y gastric bypass

KW - tablet

KW - volunteer

U2 - 10.1136/ejhpharm-2018-001804

DO - 10.1136/ejhpharm-2018-001804

M3 - Article

JO - European Journal of Hospital Pharmacy: Science and Practice

JF - European Journal of Hospital Pharmacy: Science and Practice

SN - 2047-9956

ER -

ID: 77890368