Publication

Effect of quinapril and triamterene/hydrochlorothiazide on cardiac and vascular end-organ damage in isolated systolic hypertension

Heesen, W. F., Beltman, F. W., Smit, A., May, J. F., de Graeff, P. A., Havinga, T. K., Schuurman, F. H., van der Veur, E., Meyboom-de Jong, B. & Lie, K. I., Feb-1998, In : Journal of Cardiovascular Pharmacology. 31, 2, p. 187-194 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Heesen, W. F., Beltman, F. W., Smit, A., May, J. F., de Graeff, P. A., Havinga, T. K., Schuurman, F. H., van der Veur, E., Meyboom-de Jong, B., & Lie, K. I. (1998). Effect of quinapril and triamterene/hydrochlorothiazide on cardiac and vascular end-organ damage in isolated systolic hypertension. Journal of Cardiovascular Pharmacology, 31(2), 187-194.

Author

Heesen, W.F. ; Beltman, F.W. ; Smit, Andries ; May, J.F. ; de Graeff, P.A. ; Havinga, T.K. ; Schuurman, F.H. ; van der Veur, E. ; Meyboom-de Jong, B. ; Lie, K.I. / Effect of quinapril and triamterene/hydrochlorothiazide on cardiac and vascular end-organ damage in isolated systolic hypertension. In: Journal of Cardiovascular Pharmacology. 1998 ; Vol. 31, No. 2. pp. 187-194.

Harvard

Heesen, WF, Beltman, FW, Smit, A, May, JF, de Graeff, PA, Havinga, TK, Schuurman, FH, van der Veur, E, Meyboom-de Jong, B & Lie, KI 1998, 'Effect of quinapril and triamterene/hydrochlorothiazide on cardiac and vascular end-organ damage in isolated systolic hypertension', Journal of Cardiovascular Pharmacology, vol. 31, no. 2, pp. 187-194.

Standard

Effect of quinapril and triamterene/hydrochlorothiazide on cardiac and vascular end-organ damage in isolated systolic hypertension. / Heesen, W.F.; Beltman, F.W.; Smit, Andries; May, J.F.; de Graeff, P.A.; Havinga, T.K.; Schuurman, F.H.; van der Veur, E.; Meyboom-de Jong, B.; Lie, K.I.

In: Journal of Cardiovascular Pharmacology, Vol. 31, No. 2, 02.1998, p. 187-194.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Heesen WF, Beltman FW, Smit A, May JF, de Graeff PA, Havinga TK et al. Effect of quinapril and triamterene/hydrochlorothiazide on cardiac and vascular end-organ damage in isolated systolic hypertension. Journal of Cardiovascular Pharmacology. 1998 Feb;31(2):187-194.


BibTeX

@article{a09c5b00370e44fda057a8c392adace2,
title = "Effect of quinapril and triamterene/hydrochlorothiazide on cardiac and vascular end-organ damage in isolated systolic hypertension",
abstract = "We compared, in a prospective double-blind randomized study, the effect of the angiotensin-converting enzyme inhibitor quinapril (QUI) with that of triamterene/hydrochlorothiazide (THCT) treatment on cardiovascular end-organ damage in subjects with untreated isolated systolic hypertension (ISH). End-organ damage measurements, performed initially and after 6 and 26 weeks of treatment, included echocardiographic determination of left ventricular mass index (LVMI) and of diastolic function and measurement of aortic distensibility and peripheral vascular resistance. Blood pressure was significantly reduced in the 44 subjects (21 QUI, 23 THCT) completing the study. Both LVMI and aortic distensibility had changed at 6 weeks, with comparable improvements in both groups. LV diastolic function showed overall no significant changes, although patterns of early filling did differ between the two drug groups. Peripheral vascular resistance appeared to increase between 6 and 26 weeks in THCT subjects only, along with a decreased aortic distensibility. Blood pressure and LV mass were rapidly and markedly reduced in both treatment groups of ISH subjects, paralleled by an improvement of aortic distensibility. In interpreting these results, the pathophysiologic alterations in ISH need to be taken into account, because these differ strongly from those in diastolic hypertension. Results of LV diastolic function and peripheral vascular resistance were less clear bur appear to show less favorable changes in the THCT subjects treatment group.",
keywords = "hypertension, systolic, drug treatment, echocardiography, hypertrophy, vascular, pathophysiology, LEFT-VENTRICULAR MASS, CORONARY HEART-DISEASE, DIASTOLIC FUNCTION, ANTIHYPERTENSIVE ACTION, ELDERLY SUBJECTS, HYPERTROPHY, HYDROCHLOROTHIAZIDE, DISTENSIBILITY, DETERMINANTS, CILAZAPRIL",
author = "W.F. Heesen and F.W. Beltman and Andries Smit and J.F. May and {de Graeff}, P.A. and T.K. Havinga and F.H. Schuurman and {van der Veur}, E. and {Meyboom-de Jong}, B. and K.I. Lie",
year = "1998",
month = feb,
language = "English",
volume = "31",
pages = "187--194",
journal = "Journal of Cardiovascular Pharmacology",
issn = "0160-2446",
number = "2",

}

RIS

TY - JOUR

T1 - Effect of quinapril and triamterene/hydrochlorothiazide on cardiac and vascular end-organ damage in isolated systolic hypertension

AU - Heesen, W.F.

AU - Beltman, F.W.

AU - Smit, Andries

AU - May, J.F.

AU - de Graeff, P.A.

AU - Havinga, T.K.

AU - Schuurman, F.H.

AU - van der Veur, E.

AU - Meyboom-de Jong, B.

AU - Lie, K.I.

PY - 1998/2

Y1 - 1998/2

N2 - We compared, in a prospective double-blind randomized study, the effect of the angiotensin-converting enzyme inhibitor quinapril (QUI) with that of triamterene/hydrochlorothiazide (THCT) treatment on cardiovascular end-organ damage in subjects with untreated isolated systolic hypertension (ISH). End-organ damage measurements, performed initially and after 6 and 26 weeks of treatment, included echocardiographic determination of left ventricular mass index (LVMI) and of diastolic function and measurement of aortic distensibility and peripheral vascular resistance. Blood pressure was significantly reduced in the 44 subjects (21 QUI, 23 THCT) completing the study. Both LVMI and aortic distensibility had changed at 6 weeks, with comparable improvements in both groups. LV diastolic function showed overall no significant changes, although patterns of early filling did differ between the two drug groups. Peripheral vascular resistance appeared to increase between 6 and 26 weeks in THCT subjects only, along with a decreased aortic distensibility. Blood pressure and LV mass were rapidly and markedly reduced in both treatment groups of ISH subjects, paralleled by an improvement of aortic distensibility. In interpreting these results, the pathophysiologic alterations in ISH need to be taken into account, because these differ strongly from those in diastolic hypertension. Results of LV diastolic function and peripheral vascular resistance were less clear bur appear to show less favorable changes in the THCT subjects treatment group.

AB - We compared, in a prospective double-blind randomized study, the effect of the angiotensin-converting enzyme inhibitor quinapril (QUI) with that of triamterene/hydrochlorothiazide (THCT) treatment on cardiovascular end-organ damage in subjects with untreated isolated systolic hypertension (ISH). End-organ damage measurements, performed initially and after 6 and 26 weeks of treatment, included echocardiographic determination of left ventricular mass index (LVMI) and of diastolic function and measurement of aortic distensibility and peripheral vascular resistance. Blood pressure was significantly reduced in the 44 subjects (21 QUI, 23 THCT) completing the study. Both LVMI and aortic distensibility had changed at 6 weeks, with comparable improvements in both groups. LV diastolic function showed overall no significant changes, although patterns of early filling did differ between the two drug groups. Peripheral vascular resistance appeared to increase between 6 and 26 weeks in THCT subjects only, along with a decreased aortic distensibility. Blood pressure and LV mass were rapidly and markedly reduced in both treatment groups of ISH subjects, paralleled by an improvement of aortic distensibility. In interpreting these results, the pathophysiologic alterations in ISH need to be taken into account, because these differ strongly from those in diastolic hypertension. Results of LV diastolic function and peripheral vascular resistance were less clear bur appear to show less favorable changes in the THCT subjects treatment group.

KW - hypertension

KW - systolic

KW - drug treatment

KW - echocardiography

KW - hypertrophy

KW - vascular

KW - pathophysiology

KW - LEFT-VENTRICULAR MASS

KW - CORONARY HEART-DISEASE

KW - DIASTOLIC FUNCTION

KW - ANTIHYPERTENSIVE ACTION

KW - ELDERLY SUBJECTS

KW - HYPERTROPHY

KW - HYDROCHLOROTHIAZIDE

KW - DISTENSIBILITY

KW - DETERMINANTS

KW - CILAZAPRIL

M3 - Article

VL - 31

SP - 187

EP - 194

JO - Journal of Cardiovascular Pharmacology

JF - Journal of Cardiovascular Pharmacology

SN - 0160-2446

IS - 2

ER -

ID: 3698611