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Effect of opium on glucose metabolism and lipid profiles in rats with streptozotocin-induced diabetes

Sadeghian, S., Boroumand, M. A., Sotoudeh-Anvari, M., Rahbani, S., Sheikhfathollahi, M. & Abbasi, A., 2009, In : Endokrynologia polska. 60, 4, p. 258-262 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • Saeed Sadeghian
  • Mohammad Ali Boroumand
  • Maryam Sotoudeh-Anvari
  • Shahram Rahbani
  • Mahmood Sheikhfathollahi
  • Ali Abbasi

Background: This experimental study was performed to determine the impact of opium use on serum lipid profile and glucose metabolism in rats with streptozotocin-induced diabetes.

Material and methods: To determine the effect of opium, 20 male rats were divided into control (n = 10) and opium-treated (n = 10) groups. After diabetes induction, the animals were investigated for daily glucose measurements for 35 days. Serum lipid profile and haemoglobin A1c (HbA(1c)) were assayed at the baseline (before induction of diabetes) and at 35-day follow-up.

Results: The glycaemia levels in the rats treated with opium were similar to the levels measured in the control rats (544.8 +/- 62.2 mg/dl v. 524.6 +/- 50.0 mg/dl, P = 0.434). In addition, there was no difference between the opium-treated rats and control rats in HbA(1c) (6.5 +/- 0.5% v. 6.6 +/- 0.2%, P = 0.714). Compared to the control rats, the serum total cholesterol, high density lipoprotein (HDL), triglyceride and lipoprotein (a) in the test animals were similar.

Conclusion: Opium use has no significant effect on glucose metabolism and serum lipid profile in rats with induced diabetes. (Pol J Endocrinol 2009; 60 (4): 258-262)

Original languageEnglish
Pages (from-to)258-262
Number of pages5
JournalEndokrynologia polska
Volume60
Issue number4
Publication statusPublished - 2009

    Keywords

  • opium, STZ-diabetic rats, glucose, lipid, BETA-ENDORPHIN, OPIOID RECEPTORS, PLASMA-GLUCOSE, INSULIN, ADDICTION, MORPHINE, HEROIN, MICE, CORTICOTROPIN, ASSOCIATION

ID: 4974751