Effect of inversion time on the precision of myocardial late gadolinium enhancement quantification evaluated with synthetic inversion recovery MR imagingVarga-Szemes, A., van der Geest, R. J., Schoepf, U. J., Spottiswoode, B. S., De Cecco, C. N., Muscogiuri, G., Wichmann, J. L., Mangold, S., Fuller, S. R., Maurovich-Horvat, P., Merkely, B., Litwin, S. E., Vliegenthart, R. & Suranyi, P., Aug-2017, In : European Radiology. 27, 8, p. 3235-3243 9 p.
Research output: Contribution to journal › Article › Academic › peer-review
OBJECTIVES: To evaluate the influence of inversion time (TI) on the precision of myocardial late gadolinium enhancement (LGE) quantification using synthetic inversion recovery (IR) imaging in patients with myocardial infarction (MI).
METHODS: Fifty-three patients with suspected prior MI underwent 1.5-T cardiac MRI with conventional magnitude (MagIR) and phase-sensitive IR (PSIR) LGE imaging and T1 mapping at 15 min post-contrast. T1-based synthetic MagIR and PSIR images were calculated with a TI ranging from -100 to +150 ms at 5-ms intervals relative to the optimal TI (TI0). LGE was quantified using a five standard deviation (5SD) and full width at half-maximum (FWHM) thresholds. Measurements were compared using one-way analysis of variance.
RESULTS: The MagIRsy technique provided precise assessment of LGE area at TIs ≥ TI0, while precision was decreased below TI0. The LGE area showed significant differences at ≤ -25 ms compared to TI0 using 5SD (P < 0.001) and at ≤ -65 ms using the FWHM approach (P < 0.001). LGE measurements did not show significant difference over the analysed TI range in the PSIRsy images using either of the quantification methods.
CONCLUSIONS: T1 map-based PSIRsy images provide precise quantification of MI independent of TI at the investigated time point post-contrast. MagIRsy-based MI quantification is precise at TI0 and at longer TIs while showing decreased precision at TI values below TI0.
KEY POINTS: • Synthetic IR imaging retrospectively generates LGE images at any theoretical TI • Synthetic IR imaging can simulate the effect of TI on LGE quantification • Fifteen minutes post-contrast MagIR sy accurately quantifies infarcts from TI 0 to TI 0 + 150 ms • Fifteen minutes post-contrast PSIR sy provides precise infarct size independent of TI • Synthetic IR imaging has further advantages in reducing operator dependence.
|Number of pages||9|
|Early online date||3-Jan-2017|
|Publication status||Published - Aug-2017|
- CMR, MODEL, MAGNETIC-RESONANCE, CONTRAST ENHANCEMENT , MOTION CORRECTION, INFARCT SIZE, HEART, T1, HYPERENHANCEMENT, ACCURACY, LATE GADOLINIUM ENHANCEMENT, Cardiovascular magnetic resonance, T1 mapping, Synthetic inversion recovery, Myocardial infarct